Beta Blockers and Lipoproteins: A Review of Current Knowledge

Veterans Administration Co-operative Group on Anti-hypertensive Agents. Effect of treatment on morbidity in hypertension — Results in patients with diastolic blood pressure averaging 90 through 114 mmHg. JAMA 1970; 213: 1143–1152.

Helgeland A. Treatment of mild hypertension: A five year controlled drug trial. The Oslo Study. Am J Md 1980; 69: 725–732

Hypertension Detection and Follow-Up Program Co-operative Group. Five year findings of the Hypertension Detection and Follow-Up Program: I. Reduction in mortality of persons with high blood pressure, including hypertension. JAMA 1979; 242: 2562–2571

National Heart Foundation of Australia. Management Committee. The Australian therapeutic trial in mild hypertension. Lancet 1980; 1: 1261–1267

Murphy MB Sugrue D Trayner I . Effects of short-term beta-adrenoceptor blockade on serum lipids and lipoproteins in patients with hypertension or coronary artery disease. Br Heart J 1984; 51: 589–594

Leren P Eide I Foss OP . Antihypertensive drugs and blood lipids: The Oslo Study. J Cardiovasc Pharmacol 1982; 4: 222s–224s

Lehtonen A Hietanen E Marniemi J Peltonen P Niskanen J. Effect of Pindolol on serum lipids and lipid metabolising enzymes. Br J Pharmacol 1982; 13: 445s–447s

Pasotti C Capra A Fiorella G Vibelli C Chierichetti SM . Effects of Pindolol and Metoprolol on plasma lipids and lipoproteins. Br J Clin Pharmacol 1982; 13: 435s–439s

Northcote RJ Ballantyne D. Beta-blockade and plasma lipoproteins. Comparison of the effects of propranolol and pindolol on plasma lipoproteins and HDL-subfractions. Clinical Science (in press)

van Brummelen P. The relevance of intrinsic sympathomimetic activity for beta blocker induced changes in plasma lipids. J Cardiovasc Pharmacol 1983; 5: 51s–55s

De Sommers K , Villiers LS De, Wyk M Van. Schoemann HS. The effect of Labetolol and Oxprenolol on blood lipids. S Afr Med J 1981; 60: 379–380

Ballantyne D Ballantyne FC McMurdo M. Effect of slow Oxprenolol and a combination of slow Oxprenolol and Cyclopenthiazide on plasma lipoproteins. Atherosclerosis 1981; 39: 301–306

Lehtonen A. Long-term effect of Pindolol on plasma lipids, apoprotein A, blood glucose and serum insulin levels. Int J Clin Pharmacol Ther Toxicol 1984; 22: 269–272

England JDG Hua ASP Shaw J. Beta adrenoceptor blocking agents and lipid metabolism. Clin Sci Mol Med 1978; 55: 323s–324s

Karmakoski J Viikari J Ronnemaa T. Effect of Pindolol on serum lipoproteins in patients with coronary heart disease. Int J Clin Pharmacol Ther Toxicol 1983; 21: 189–191

Leren P Foss OP Helgeland A Hjermann I Holme I. Effects of Pindolol and Hydrochlorothiazide on blood lipids. The Oslo Study. Clinical Trials Journal 1981; 18: 254–261.

Bjorntorp P. The treatment of angina pectoris with a new beta receptor blocking agent (H56/28). Acta Med Scand 1967; 182: 285–291

Jurgensen HJ Meinertzh Faergeman O. Plasma lipids and lipoproteins in long-term beta adrenergic blockade. Acta Med Scand 1982; 221: 449–452

Wallace RB Hunninghage DB Reiland S . Alterations of plasma high-density lipoprotein cholesterol levels associated with consumption of selected medications. The lipid Research Clinics Program Prevalence Study. Circulatin 1980; 62 (Suppl IV): 77–82

Leren P Helgeland A Holme I Foss PO Hjermann I Lund-Larsen PG . Effect of Propranolol and Prazosin on blood lipids: The Oslo Study. Lancet 1980; 2: 4–6

Bengtsson C Lennartsson J Lindquist G . On metabolic effects of diuretics and beta blockers. Acta Med Scand 1982; 212: 57–64

Barboriak JJ Friedberg HD . Propranolol and hypertriglyceridaemia. Atherosclerosis 1973; 17: 31–35

Tanaka N Sakaguchi S Oshige K Niimura T Kanehisa T. Effect of chronic administration of propranolol on lipoprotein composition. Metabolism 1976; 25: 1071–1075

Day JL Simpson N Metcalfe J Page RL . Metabolic consequences of Atenolol and Propranolol in the treatment of hypertension. Br Med J 1979; 1: 77–80

Streja D Mynin D. Effect of Propranolol on HDL cholesterol concentrations. Br Med J 1978; 2: 1495

Schauer I Schauer U Ruhling K Thielmann K. The effect of propranolol treatment on total cholesterol, HDL cholesterol, triglycerides, post heparin lipolytic activity and lecithin: Cholesterol acyltransferase in hypertensive individuals. Artery 1980; 8 (2): 146–150

Goto Y. Effects of alpha and beta blocker antihypertensive theraphy on blood lipids: A multicentre Trial. Am J Med 1984; 76: 72–78

Bauer JH Brooks CS Weinstein I . Effect of diuretic and propranolol on plasma lipoprotein lipids. Clin Pharmacol Ther 1981; 30: 35–43

Gemma G Montanari G Suppa G . Plasma lipid and lipoprotein changes in hypertensive patients treated with Propranolol and Prazosin. J Cardiovasc Pharmacol 1982; 4: 233s–237s

Lehtonen A Viikari J. Long-term effect of Sotalol on plasma lipids. Clin Sci Mol Med 1979; 57: 405–407

Northcote RJ Packard C Ballantyne D. The effect of Sotalol on plasma lipoproteins. Clin Chim Acta 1986; 158: 187–192

Eliasson K Lins LE Rossner S. Serum lipoprotein changes during Atenolol treatment of essential hypertension. Eur J Clin Pharmacol 1981; 20: 335–338

Nilsson A Hannson BG Hokfelt B. Beta blockers and lip-id metabolism. Br Med J 1977; 2: 126

England JD Simons LH Gibson JC Carton M. The effect of Metoprolol and Atenolol on plasma high density lipoprotein levels in man. Clin Exp Pharmacol Physiol 1980; 7: 329–333

Waal-Manning HJ Bolli P. Atenolol v placebo in mild hypertension: Renal, metabolic and stress anti-pressor effects. Br J Clin Pharmacol 1980; 9: 553–560

Kristensen BO . Effect of long-term treatment with beta blocking drugs on plasma lipids and lipoproteins. Br Med J 1981, 283: 191–192

Ghosh P Cochrane AMG de Bono D. Effects of long-term practolol therapy on plasma lipids after acute myocardial infarction. Lancet 1975; 1: 9–10

Day JL Metcalfe J Simpson CN . Adrenergic mechanisms in control of plasma lipid concentrations. Br Med J 1982; 284: 1145–1148

Lehtonen A. Adrenergic mechanisms in control of plasma lipid concentrations. Br Med J 1982; 28: 1708 (Letter)

Leiss O Muranowski U Egge H. Lecithin cholesterol acyltransferase activity in relation to lipoprotein concentration and lipid composition. Scan J Clin Lab Invest 1978; 38, Suppl 150: 77–84

Lager J Blohme G Smith V. Effect of cardioselective and non-selective beta blockade on the hypoglycaemic response in insulin dependent diabetics. Lancet 1979; 1: 458–462

Kekki M. Lipoprotein lipase action determining plasma high density lipoprotein cholesterol level in adult normolipaemics. Atherosclerosis 1980; 37: 143–150

Ashby P Parkin SM Walker K Bennett DP Robinson DS . Hormonal control of adipose tissue lipoprotein lipase activity. INSERM Symposia 1980; 87: 149–60

William-Olsson T Fellenius E Bjorntorp P Smith U. Differences in metabolic responses to beta-adrenergic stimulation after propranolol or metoprolol administration. Acta Med Scand 1979; 205: 201–206

Sirtori CR Gianfranceschi G Sirtori M . Reduced triglyceridaemia and increased high density lipoprotein cholesterol levels after treatment with acipimox, a new inhibitor of lipolysis. Atherosclerosis 1981; 38: 267–271

Ames RP Hill P. Elevation of serum lipid levels during diuretic therapy of hypertension. Am J Med 1976; 61: 748

Bielmann P Leduc G. Effects of Metoprolol and Propranolol on lipid metabolism. Int J Clin Pharmacol Biopharm 1979; 17: 378–382

Reynolds JL Whitlock RML . Effects of a beta-adrenergic receptor blocker in myocardial infarction treated for one year from onset. Br Heart J 1972; 34: 252–259

Vedin A Wilhelmsson C Werko L. Chronic alprenolol treatment of patients with acute myocardial infarction after discharge from hospital. Effects on mortality and morbidity. Acta Med Scand 1975; (575): 3–56

Tarazi RC Dustan HP Frohlich ED . Long-term thiazide therapy in essential hypertension. Circulation 1970; 41: 708–717

Carlson LA Bottiger LE Ahfeldt PE . Risk factors for myocardial infarction in the Stockholm Prospective Study. Acta Med Scand 1979; 206: 351–360

Miller NE Hammett F Saltissi S . Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins. Br Med J 1981; 282: 1741–1744

Thomson G. Editorial: Apoproteins: Determinants of lipoprotein metabolism and indices of coronary risk. Br Heart J 1984; 51: 585–588

Beinart IW Cramp DG Pearson RM Harvard CWH . The effect of Metoprolol on plasma lipids. Postgrad Med J 1979; 55: 709–711

Jurgensen HJ Meinertz H Faergeman O. Plasma lipids and lipoproteins in long-term beta adrenergic blockade. Acta Med Scand 1982; 221: 449–452