An excellent response to treatment with thiazide diuretic for twelve years is described in a patient with Gordon's Syndrome, the first to be reported from Scotland, and only the second to manifest the full clinical picture of short stature, hypertension, hyperkalaemia and hyperchloraemic acidosis without renal failure. The hypertension and biochemical abnormalities were reversed during therapy. Temporary withdrawal after seven years was followed by the immediate return of all the biochemical abnormalities, but not of the hypertension.
GordonRDGeddesRAPawseyCGKO'HalloranMW. Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction. Aust Ann Med1970; 4: 287–294.
2.
De WardenerHE. Selective defects of tubular function. In: The kidney: an outline of normal and abnormal structure and function, 4th Edition. Edinburgh: Churchill Livingstone1973: 230–243.
3.
WeinsteinSFAllenDMEMendozaSA. Hyperkalaemia, acidosis and short stature associated with a defect in renal potassium excretion. J Pediat1974; 85: 355–358.
4.
FarfelZIainaARosenthalTWaksUShiboletSGafniJ. Familial hyperpotassaemia and hypertension accompanied by normal plasma aldosterone levels. Possible hereditary cell membrane defect. Arch Intern Med1978; 138: 1828–1832.
5.
GrekinRJNichollsMGPadfieldPL. Disorders of chloriuretic hormone secretion. Lancet1979; 1: 116–118.
