A 78-year-old woman presented with an acute abdomen and was found to have a perforation of her terminal ileum. She did not survive the postoperative period and at necropsy was found to have numerous ulcers of the ileum. In the ulcerated areas there was a transmural chronic inflammatory infiltrate, but no evidence of granulomata. We believe that this ulceration was caused by ingestion of Osmosin tablets containing indomethacin and suggest a possible pathogenesis.
Committee on Safety of Medicines. Osmosin (Controlled release indomethacin). Current Problems 1983: 11.
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