A cord blood sample obtained after a perfectly normal pregnancy was found to be HLA-A, B, C and DR compatible with maternal HLA antigens. This minority occurrence is discussed in relation to the possible use of tissue-typing to assess risk of spontaneous abortion.
FaulkWPTempleALovinsRESmithM.Antigens of human trophoblasts: A working hypothesis for their role in normal and abnormal pregnancies. Proc Natl Acad Sci USA1978; 75: 1947–1951.
2.
RedmanCWG. Immunological factors in the pathogenesis of pre-eclampsia. Contr Nephrol1981; 25: 120–127.
3.
TaylorCFaulkWP. Prevention of recurrent abortion with leucocyte transfusions. Lancet1981; 2: 68–70.
4.
MerretJDHunterRJ. Serum heat labile alkaline phosphatase levels in normal and abnormal pregnancies. J Obstet Gynaecol Brit Commonw1973; 80: 957–965.
5.
BaurMPDanilovJA. Reference tables of two and three-locus haptotype frequencies for HLA-A, B, C, DR, Bf and GLO. In Ed. TerasakiPI. Histocompatibility Testing 1980. Los Angeles: UCLA Tissue Typing Laboratory1980; 994–1210.
6.
RedmanCWGBodmerJGBeilinLJBonnarJ.HLA antigens in severe pre-eclampsia. Lancet1978; 2: 397–399.
7.
Werner-FaureCJeannetM.HLA compatibility in couples with children suffering from acute leukaemia or aplastic anaemia. Tissue Antigens1979; 13: 307–309.