Treatment of Postmenopausal Osteoporosis: Some Current Concepts

Abstract

Postmenopausal osteoporosis, a condition of deficient bone mass, is associated with fractures of the spine, distal radius and ulna, and femoral neck. Its pathogenesis may be a disruption (‘negative uncoupling’) of the normal bone remodelling sequence; therapeutic benefit may be achieved with further alteration of this sequence (‘positive uncoupling’). A current therapeutic regimen of increased calcium intake, small amounts of vitamin D, an anabolic steroid (such as stanozolol) and possibly fluoride would appear to be of benefit in postmenopausal osteoporosis.