A double blind crossover trial of baclofen against placebo was carried out in 20 children with spasticity in a day school for physically handicapped children. No significant benefit from baclofen in functional activities was observed and an unacceptable incidence of side-effects was recorded. However, interesting differences between the observations during formal testing and during everyday activities were noted and these may have implications for future trials. A longer study using a lower dose (e.g. 1 mg/kg) might achieve different results.
Leading article. Randomised controlled trials. Brit Med J1979; 2: 1244–1245.
2.
CranbergL. Do retrospective controls make clinical trials inherently fallacious?Brit Med J1979; 2: 1265–1266.
3.
EbbuttAFJukesAM. United Kingdom therapeutic trial of Lioresal in the treatment of spasticity of cerebral origin. In: JukesAM, ed. Baclofen: Spasticity and Cerebral Pathology. Northampton: Cambridge Medical Publications1978; 109–115.
4.
MillaPJJacksonADM. A controlled trial of baclofen in children with cerebral palsy. J Int Med Res1977; 5: 398–104.
5.
CanningBARoseNF. Clinical measurements of the speed of tongue and lip movements in British children with normal speech. Brit J Disord Commun1974; 9: 45–50.
