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Abstract

Since their introduction almost 30 years ago, topical corticosteroids have made a dramatic contribution to the management of a wide range of noninfective skin disorders. Their principal mode ofaction is anti-inflammatory and a variety of potencies and vehicles is available. Several important side effects have been described, of which skin atrophy is the most common, but with careful usage the risks are not great.

Topical corticosteroids are contraindicated in certain conditions.

Keywords

Topical corticosteroids Dermatology

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References

Sulzberger

Witten

. The effect of topically applied compound F in selected dermatoses. J Invest Dermatol 1952; 19: 101.

Maibach

. In vivo percutaneous penetration of corticoids in man and unresolved problems in their efficacy. Dermatologica 1976; 152 (suppl. 1): 11–25.

United States Census Bureau Report, 1974.

Calnan

. Use and abuse of topical steroids. Dermatologica 1976: 152 (suppl. 1): 247–251.

Anonymous. The management of chronic discoid psoriasis. Drug Ther Bul 1978; 16: 25–27.

Bleehen

. The treatment of vitiligo with topical corticosteroids. Br J Dermatol 1976; 94 (suppl. 12): 43–50.

Lehner

. Steroids and oral disease. Br J Dermatol 1976: 94 (suppl. 12): 59–60.

Verbov

. The place of intralesional steroid therapy in dermatology. Br J Dermatol 1976; 94 (suppl. 12): 51–58.

Stewart

Danto

Maddin

. Dermatology: Diagnosis and treatment of cutaneous disorders. Saint Louis: Mosby 1978.

10.

Fisher

Maibach

. Effects of corticosteroids on human epidermal mitotic activity. Arch Dermatol 1971; 103: 39.

11.

MacKenzie

Stoughton

. Method of comparing percutaneous absorption of steroids. Arch Dermatol 1962; 86: 608.

12.

DuVivier

. Tachyphylaxis to topically applied steroids. Archiv Dermatol 1976; 98: 209.

13.

Vickers

CFH

. Existence of reservoir in the stratum corneum. Experimental proof. Arch Dermatol 1963; 88: 20.

14.

Vickers

CFH

. Dam, Reservoir or Filter. Trans St John's Dermatol Soc. 1973; 59: 10–29.

15.

Sneddon

. Clinical use of topical corticosteroids. Drugs 1976; 11: 193–199.

16.

Barry

. Bioavailability of topical steroids. Dermatologica 1976; 152 (suppl. 1): 47–65.

17.

Baker

. Experimental studies on influence of vehicles on percutaneous absorption. J Soc Cosm Chem Br Edn 1969; 20: 239.

18.

Tree

Marks

. An explanation for the ‘placebo’ effect of bland ointment bases. Br J Dermatol 1975; 92: 195.

19.

Baxter

Stoughton

. Mitotic index of psoriatic lesions treated with anthralin, gluccco-costeroid and occlusion only. J Invest Dermatol 1970; 54: 410.

20.

Cunliffe

Burton

Holti

Wright

. Hazards of steroid therapy in hepatic failure Br J Dermatol 1975; 93: 183.

21.

Almeyda

Burt

. Double blind controlled study of atopic eczema with a preparation of hydrocortisone in a new drug delivery system versus betemethasone 17-valerate. Brit J Dermatol 1974; 91: 597–583.

22.

MacKenzie

Wilkinson

. Topical therapy. Recent Adv in Dermatol 1977; 4: 281–327.

23.

Asboe-Hansen

. Influence of corticosteroids on connective tissue. Dermatologica 1976; 152 (suppl 1): 127–132.

24.

Epstein

. Atrophic striae in patients with inguinal intertigo. Arch Dermatol 1963; 87: 450.

25.

Stevanovic

. Corticosteroid induced atrophy of the skin with telangiectasia. Br J Dermatol 1972; 87: 548.

26.

Grice

. Tinea of the hand and forearm. Betamethesone valerate atrophy. Proc R Soc Med 1966; 59: 254.

27.

Delforno

Holt

PJA

Marks

. Corticosteroid effect on epidermal cell size. Br J Dermatol 1978; 98: 619–623.

28.

Sneddon

. A trial of hydrocortisone butyrate in the treatment of rosacea and perioral dermatitis. Br J Dermatol 1973; 89: 505.

29.

Dykes

Marks

. An appraisal of the methods used in the assessment of atrophy from topical corticosteroids. Br J Dermatol 1979; 101: 599.

30.

Anonymous. Corticosteroids for the skin. Drug Ther Bull 1977; 15: 5–8.

31.

Sneddon

. Adverse effects of topical corticosteroids in rosacea. Br Med J 1969; 1: 671.

32.

Stankler

Ewen

SWB

. The effects of corticosteroid injections at sites of skin damage. J Invest Dermatol 1972; 59: 394.

33.

Marks

. Concepts in the pathogenesis of rosacea. Br J Dermatol 1968; 80: 170.

34.

Marples

Rebora

Kligman

. Topical steroid-antibiotic combinations-assay of use in experimentally induced human infections. Arch Dermatol 1973; 108: 237.

35.

Ive

Marks

. Tinea incognito. Br Med J 1968; 3: 149.

36.

Boxley

Dawber

RPR

Summerly

. Generalized pustular psoriasis on withdrawal of clobetasol propionate ointment. Br Med J 1975; 2: 255.

37.

Weber

. Rosacea-like dermatitis. Contraindication or intolerance reaction to strong steroids. Br J Dermatol 1972; 86: 253.

38.

Sneddon

. Perioral dermatitis. Br J Dermatol 1972; 83: 430.

39.

Cochran

REI

. Thomson J. Perioral dermatitis: a reappraisal. Clin Exp Dermatol 1979; 4: 75–80.

40.

Wilkinson

Kirton

Wilkinson

. Perioral dermatitis: a 12-year review. Br J Dermatol 1979; 101: 245–257.

41.

Cotterill

. Perioral dermatitis. Br J Dermatol 1979; 101: 259–262.

42.

Scoggins

. Decrease of urinary corticosteroid following applications of fiuocinonide acetonide under an occlusive dressing. J Invest Dermatol 1962; 39: 473.

43.

Munro

. The effect of percutaneously absorbed steroids on hypothalmic-pituitary-adrenal function after intensive use in in-patients. Br J Dermatol 1976; 94 (suppl. 12): 67–76.

44.

Alani

. Allergic contact dermatitis to corticosteroids. Ann Allergy 1972; 30: 181.

45.

Bedi

. Intradermal triamcinolone acetonide treatment of psoriatic onychodystrophy. Dermatologica 1977; 155: 24–27.

46.

Cubey

. Glaucoma following the application of corticosteroid to the skin of the eyelids. Br J Dermatol 1976; 95: 207–208.

47.

Woodbridge

Sparkes

. Managing chronic skin conditions with two differing topical corticosteroids. Dermatologica 1979; 158: 279–306.

48.

Noble

Sarin

. Steroid cream contaminated with Ps.aeruginosa. Lancet 1966; 1: 347.

49.

Baird

Brown

WRL

Shooter

. Ps.aeruginosa in hospital pharmacies. Br Med J 1976; 1: 511.

The use and Abuse of Topical Corticosteroids in Dermatology

Abstract

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References