The ectopic production of hormones by tumours is important to appreciate as relevant endocrine features may antedate the appearance of other evidence of the tumour. This possibility should be borne in mind particularly when considering Cushing's syndrome, excessive ADH production or hypercalcaemia and could result in many instances in a quite different approach to further investigation and management. Carcinoma of lung is the commonest underlying neoplasm in several such situations but there are some, such as the hypoglycaemic syndromes, in which the tumour may even be benign.
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References
1.
ReesLH. The biosynthesis of hormones by non-endocrine tumours-a review. J Endocrinol1975; 67: 143–175.
2.
BrownWH. A case of pluriglandular syndrome. Lancet1928; 2: 1022–1023.
3.
WinklerWACranshawOF. Chloride depletion in conditions other than Addison's disease. J Clin Invest1938; 17: 1–6.
4.
SchwartzWBBennetWCurelopSBarrterFC. A syndrome of renal sodium loss and hyponatraemia probably resulting from inappropriate secretion of anti-diuretic hormone. Am J Med1957; 23: 529–542.
5.
OdellWDWolfsenAR. Humoral syndromes associated with cancer. Annu Rev Med1978; 29: 379–406.
6.
TurkingtonRW. Ectopic production of prolactin. N Engl J Med1971; 285: 1455–1458.
7.
HennenG. Characterisation of a thyroid-stimulating factor in human cancer tissue. J Clin Endocrinol Metab1967; 27: 610–614.
8.
DabekJT. Bronchial carcinoid with acromegaly in two patients. J Clin Endocrinol Metab1974; 38: 329–333.
9.
ShaletSMBeardwellCGMacFarlaneIAAcromegaly due to production of a growth hormone releasing factor by a bronchial carcinoid tumour. Clin Endocrinol1979; 10: 61–67.
