Intravenous disopyramide was used in 13 patients who developed recurrent ventricular dysrhythmias despite initial treatment with intravenous lignocaine after admission to the Coronary Care Unit of a busy district hospital. This was effective in 8 of the 13 patients treated and there was no major side effects observed. Disopyramide has the advantage of being available both as an oral and an intravenous preparation and is a useful drug to be added to the list of more conventional anti-dysrhythmic agents.
Get full access to this article
View all access options for this article.
References
1.
British Medical Journal (1974). Leading Article. Adverse reaction to beta-adrenergic blockade. British Medical Journal, 2, 3
2.
BrownK. W. G.MacMillanR. L.ForbathN.Mel'GranoF.ScottJ. W. (1963). Coronary care unit. An intensive care centre for acute myocardial infarction. Lancet, 2, 349
3.
ChopraM. P.ThadaniU.PortalR. W.AberC. P. (1971). Lignocaine therapy for ventricular ecoptic activity after acute myocardial infarction. British Medical Journal, 3, 668
4.
DarbyS.CruikshankJ. C.BennettM. A.PentecostB. L. (1972). Trial of combined intramuscular and intravenous lignocaine in the prophylaxis of ventricular tachyarrhythmias. Lancet, 1, 817
5.
GeddesJ. S.WebbS.PantridgeJ. F. (1972). Limitations of lignocaine in the control of early ventricular dysrhythmias complicating acute myocardial infarction. British Heart Journal, 34, 964
6.
GiannellyR.von Der GroebenJ. O.SpivackA. P.HarrisonD. C. (1967). Effect of lignocaine on ventricular arrhythmias in patients with Coronary artery disease. New England Medical Journal, 277, 1215
7.
GobleA. J.SlomanG.RobinsonJ. S. (1966). Mortality reduction in a coronary care unit. British Medical Journal, 1, 1005
8.
GreenblattD. J.BologniniV.Koch-WeserJ.HarmatzJ. S. (1976). Pharmacokinetic approach to the clinical use of lidocaine intravenously. Journal of the American Medical Association, 236, 273
9.
HillisW. S.TweedelA.LorimerA. R.LawrieT. D. V. (1976). Some aspects of the clinical pharmacology of intravenous disopyramide after myocardial infarction. Journal of Internal Medical Research, 4, Supplement 1, 74
10.
JenningsG.BestermanE. M. M.JonesM. B. S.ModelD. G.TurnerP. P.KidnerP. H. (1976). Oral disopyramide in prophylaxis of arrythmias following myocardial infarction. Lancet, 1, 56
11.
JewittD. E.KishonY.ThomasM. (1968.) Lignocaine in the management of arrythmias after acute myocardial infarction. Lancet, 1, 266
12.
JulianD. G.ValentineP. A.MillerG. G. (1964). Disturbances of rate, rhythm of conduction in acute myocardial infarction. American Journal of Medicine, 37, 915
13.
LieK. I.WellensH. J.van CapelleF. J.DurrerD. (1974). Lidocaine on the prevention of primary ventricular fibrillation. New England Medical Journal291, 1324
14.
LownB.FakhroA. M.HoodW. B.ThornG. W. (1967). The coronary care unit. Journal of American Medical Association, 199, 188
15.
MizgalaW. F.HuvelleP. R. (1976). Acute termination of cardiac arrythmias with intravenous disopyramide. Journal of Internal Medical Research4, Supplement: 1, 82
16.
MunaW.OstermanF. A.Jrn.StevensM. B. (1976). Procainamide induced lupus. John Hopkins Medical Journal, 138, 289
17.
PrescottL. F.Adjepon-YamoahK. K.TalbotR. G. (1976). Impaired lignocaine metabolism in patients with acute myocardial Infarction and cardiac failure. British Medical Journal1, 939
18.
RydenL.WaldenstromA.WinsngsY.OrtengrenB. (1975). Blood levels of lidocaine after various infusion rates in patients with acute myocardial infarction. American Heart Journal, 89, 470
19.
SpacklenF. H. N.KimerlingJ. J.BestermanE. M. M.LitchfieldJ. W. (1968). Use of lignocaine in the management of arrythmias after acute myocardial infarctionLancet, 1, 266
20.
ThomsonP. D.MelmonK. L.RichardsonJ. A.CohnK.SteinbrunnW.CudiheeR.RowlandM. (1973). Lidocaine pharmacokinetics in advanced heart failure, liver disease and renal failure in humans. Annals of Internal Medicine78, 499
21.
ZainalN.CarmichaelD. J. S.GriffithsJ. W.BestermanE. M. M.KidnerP. H.GillhamA. D.SummersG. D. (1977). Oral disopyramide for the prevention of arrhythmias in patients with acute myocardial infarction admitted to open wards. Lancet2, 887