The concentration of cephazolin in the serum, gall bladder bile, common duct bile, and gall bladder wall were considerably higher than cephalothin especially with IV administration and indicate that cephazolin should be a useful antibiotic in the surgical treatment of acute cholecystitis.
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References
1.
AyliffeG. A. J.DavisA. (1965). Ampicillin levels in human bile. Journal of Pharmacology and Chemotherapy, 24, 189
2.
BrogardJ. M.DornerM.PingetM.AdloffM.LavillaureixJ. (1975). The biliary excretion of cefazolin. Journal of Infectious Diseases, 131, 625
3.
ChetlinS. H.ElliottD. W. (1973). Preoperative antibiotics in biliary surgery. Archives of Surgery, 107, 319
4.
ChetlinS. H.ElliottD. W. (1971). Biliary bacteremia. Archives of Surgery, 102, 303
5.
GriffithR. S.BlackH. R. (1971). Blood, urine and tissue concentrations of the cephalosporin antibiotics in normal subjects. Postgraduate Medical Journal, Supplement47, 32
6.
GroveD.RandallW. (1955). In Assay methods of antibiotics: a laboratory manual, Edited by WelshH.Marti-IbanexF., Medical Encyclopedia, Inc: New York
7.
HammondJ. B.GriffithR. S. (1961) Factors affecting the absorption and biliary excretion of erythromycin and two of its derivatives in humans. Clinical Pharmacology and Therapeutics, 2, 308
8.
HoffmanT. A. (1970). Pharmacodynamics of carbenicillin in hepatic and renal failure. Annals of Internal Medicine, 73, 173
9.
MadhavanT.QuinnE. L.FreimerE.FisherE. J.CoxF.BurchK.PohlodD. (1973). Clinical studies of cefazolin and comparison with other cephalosporinsAntimicrobial Agents and Chemotherapy, 4, 525
10.
MedinaA. (1968). Absorption, diffusion, and excretion of a new antibiotic, lincomycin. Antimicrobial Agents and Chemotherapy, p. 189, American Society for Microbiology: Bethesda
11.
MendelsonJ.PortnoyJ.SigmanH.DickV. (1974) Pharmacology of cephalothin in the biliary tract of humans. Antimicrobial Agents and Chemotherapy, 6, 659
12.
MortimerP. R.MackieD. B.HaynesS. (1969). Ampicillin levels in human bile in the presence of biliary tract disease. British Medical Journal, 3, 88
13.
RamM. D.WatanatittanS. (1973). Levels of cefazolin in human bile. Journal of Infectious Diseases, Supplement128, 361
14.
RatzanK. R.RuizC.IrvinG. L.III. (1974). Biliary tract excretion of cefazolin, cephalothin and cephaloridine in the presence of biliary tract disease. Antimicrobial Agents and Chemotherapy6, 426
15.
SmithivasT.HyamsP. J.RahalJ. J.Jr. (1971). Gentamicin and ampicillin in human bile. Journal of Infectious Diseases, 124, Supplement 106
16.
ZaslowJ.CounselorV. S.HeilmanF. R. (1954–55). The excretion and concentration of Oxytetracycline in bile following intramuscular administration of the drug. Antibiotics Annual, p 964
