Frusemide was added to the perfusate used to flush kidneys prior to transplantation. The 133Xe wash-out technique was used to measure renal blood flows before and after transplantation and the clearance curves were analysed into cortical and medullary components. It is concluded that the addition of frusemide to the perfusate contributes significantly to the restoration of a satisfactory blood flow to a transplanted kidney.
Get full access to this article
View all access options for this article.
References
1.
BelzerF. O.ReedT. W.PryorJ. P.KountzS. L.DunphyJ. E. (1970). Cause of renal injury in kidneys from cadaver donors. Surgery, Gynaecology and Obstetrics, 130, 467.
2.
BirtchA. G.ZakheimR. M.JonesL. G.BargerA. C. (1967). Redistribution of renal blood flow production by furosemide and ethacrynic acid. Circulation Research, 21, 869.
3.
BlaufoxM. D.FromowitzA.GrushinA.Chien-HsingM.ElkinM. (1970). Validation of use of xenon 133 to measure intrarenal distribution of blood flow. American Journal of Physiology, 219, 440.
4.
BruniusU.BergentzS. E.EkmanH.GelinL. E.WestburgG. (1968). The cadaveric kidney in clinical transplantation. Scandinavian Journal of Urology and Nephrology, 2, 15.
5.
CollinsG. M.Bravo-ShugarmanM.TerasakiP. I. (1969). Kidney preservation for transportation. Lancet, 2, 1219.
6.
DempsterW. J. (1971). The nature of experimental second-set kidney transplant rejection. British Journal of Experimental Pathology, 52, 172.
7.
DobsonE. L.WarnerG. F. (1957). Measurement of regional sodium turnover rates and their application to the estimation of regional flow. American Journal of Physiology, 189, 269.
8.
FernandoO. N.NewmanS. P.HirdV. M.SampsonD. G.WilliamsH. S.HopewellJ. P.ReadP. R.MoorheadJ. F. (1973). Jmprovement of blood flow in transplanted kidneys in dogs using a frusemide-added perfusate. Transplantation, 16 (4), 374.
9.
HookJ. B.BlattA. H.BrodyM. J.WilliamsonH. E. (1966). Effects of several saluretic-diuretic agents on renal haemodynamics. Journal of Pharmacology and Experimental Therapeutics, 154, 667.
10.
KewM. C.VarmaR. R.WilliamsH. S.BruntP. W.HouriganK. J.SherlockS. (1971). Renal and intrarenal blood-flow in cirrhosis of the liver. Lancet, 2, 504.
11.
LadefogedJ. (1966). Measurements of the renal blood flow in man with the xenon-133 wash-out technique. Scandinavian Journal of Clinical and Laboratory Investigation, 18, 299.
12.
LadefogedJ.PedersenF.DoutheilU.DeetjenP.SelkurtE. E. (1965). Renal blood flow measured with xenon-133 wash-out technique and with an electromagnetic flowmeter. Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere, 284, 195.
13.
LewisD. H.FritjofssonA. (1968). Comparison of xenon-133 wash-out curves from the kidney with direct measurement of renal venous outflow. Scandinavian Journal of Urology and Nephrology, 2, 62.
14.
LowenthalJ. (1971). Kidney transplantation. Annals of the Royal College of Surgeons, England, 49, 194.
15.
NewmanM. H.SkinnerD. B. (1969). Comparative measurement of renal blood flow by xenon-133 clearance and electromagnetic flowmeter methods. American Surgeon, 35, 879.
16.
PanijayanondP.SangIn ChoUlrichF.NalsethD. C. (1973). Enhancement of renal preservation by furosemide. Surgery, 73, 368.
17.
PilkingtonL. A.BinderR.De HaasJ. O. M.PittsR. F. (1965). Intrarenal distribution of blood flow. American Journal of Physiology, 208, 1107.
18.
RamM. D.EvansK.ChishohnG. D. (1968). A single injection method for measurement of effective renal plasma flow. British Journal of Urology, 40, 425.
19.
ReubiF. C. (1966). Clinical use of furosemide. Annals of the New York Academy of Sciences, 139, 433.
20.
SacksS. A.PetritschP. H.KaufmanJ. J. (1973). Canine kidney preservation using a new perfusate. Lancet, 1, 1024.
21.
SlotkoffL. M.LoganA.JoseP.D'AvellaJ.EisnerG. M. (1971). Microspheres measurement of intrarenal circulation of the dog. Circulation Research, 28, 58.
22.
TaquiniC. M.YeyatiN. L.TaquiniA. C. (1969). Acute renal haemodynamic effects by inhibition of tubular sodium re-absorption. Acta physiologica Latino-Americana, 19, 64.
23.
ThorburnG. D.KopaldH. H.HerdJ. A.HollenbergM.O'MorchoeC. C. C.BargerA. C. (1963). Intrarenal distribution of nutrient blood flow determined with krypton-85 in the unanaesthetized dog. Circulation Research, 13, 290.
24.
ThorauK.DeetjenP.KramerK. (1960). Hämodynamik des Nierenmarks. Pflugers Archiv für die gesamte Physiologie des Menschen und der Tiere, 270, 270.
25.
WolgastP. (1968). Studies on the regional renal blood flow with 32P-labelled red cells and small β-sensitive semiconductor detectors. Acta physiologica Scandinavica, Supp. 313.
26.
PanijayanondP.ChoS. I.UlrichF.NabsethD. C. (1973). Enhancement of renal preservation by furosemide. Surgery, 73, 368.
