Acute experiments involving a single dose of salicylazosulphapyridine (SASP) were performed in 5 volunteers. The peak serum concentration of SASP was found within 3 to 5 hours whereas for sulphapyridine derived from SASP it occurred at 12 to 24 hours. The addition of ferrous sulphate caused a significant decrease in the serum SASP concentration whereas the addition of calcium gluconate delayed the absorption of SASP without disturbing the degree of absorption. Total sulphapyridine concentration did not show any variation.
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References
1.
BaronJ. H.ConnellA. M.Lennard-JonesJ. E.JonesF. A. (1962). Sulphasalazine and salicylazosulphadimidine in ulerative colitis. Lancet, 1, 1094.
2.
DickA. P.GraysonM. J.CarpenterR. G.PetrieA. (1964). Controlled trial of sulphasalazine in the treatment of ulcerative colitis. Gut, 5, 437.
3.
EvansD. A. P. (1969). An improved and simplified method of detecting the acetylator phenotype. Journal of Medical Genetics, 6, 405.
4.
GoldsteinF.MurdockM. G. (1971). Clinical and radiological improvement of regional enteritis and enterocolitis after treatment with salicylazosulphapyridine. American Journal of Digestive Diseases, 16, 421.
5.
HanssonK. A.SandbergM. (1973). Determination of sulphapyridine and its metabolites in biological materials after administration of salicylazosulphapyridine. Acta Pharmaceutica Suecia, in press.
6.
HuntJ. N.PathakJ. D. (1960). The osmotic effects of some simple molecules and ions on gastric emptying. Journal of Physiology, 154, 254.
7.
MisiewiczJ. J.Lennard-JonesJ. E.ConnellA. M.BaronJ. H.JonesF. A. (1965). Controlled trial of sulphasalazine in maintenance therapy for ulcerative colitis. Lancet, 1, 185.
8.
NeuvonenP. J.GothoniC.HackmanR.BjorkstenK. (1970). Interference of iron with the absorption of tetracyclines in man. British Medical Journal, 4, 532.
9.
PalmerR. F. (1971). Drug interactions. Medical Clinics of North America, 55, 2, 495.
10.
SandbergM.HanssonK. A. (1973). Determination of salicylazosulphapyridine in biological materials. Acta Pharmaceutica Suecia, in press.
11.
SchroderH.CampbellD. E. S. (1972). Absorption, metabolism and excretion of salicylazosulphapyridine in man. Clinical Pharmacology and Therapeutics, 13, 539.
12.
SchroderH.Price-EvansD. A. (1972). The polymorphic acetylation of sulphapyridine in man. Journal of Medical Genetics, 9, 168.
13.
SvartzN. (1942). Salazopyrin, a new sulfanilamide preparation. (B) Therapeutic results in ulcerative colitis. Acta Medico Scandinavica, 110, 577.
