Two non-diabetic girls were observed following self-poisoning with chlorpropamide. The dominant feature was prolonged hypoglycaemic coma, which lasted 3 days in one case, and led to death in the other. High serum levels of chlorpropamide were demonstrated and this was correlated with sustained high levels of plasma insulin. In the light of the results obtained, the role of glucagon in the management of such cases is discussed, and the requirement for observation in an intensive care unit is emphasised.
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