Firm or suggestive evidence of congenital infection was obtained in 25 (10.5%) of 239 children under 1-year-old with suspected embryopathy in the west of Scotland during the 4-year period from September 1966. The numbers of infections associated with the various agents studied were: rubella 11, coxsackievirus 4, cytomegalovirus 3, herpes simplex 3, toxoplasma 3, mumps 1. Persisting residual defects were found in 17 of these 25, 9 being associated with congenital rubella.
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References
1.
BellE. J., GristN. R. (1970). Further studies of enterovirus infections in cardiac disease and pleurodynia. Scandinavian Journal of Infectious Diseases, 2, 1
2.
British Medical Journal (1967). Leading Article. Mumps and cardiac embryopathy. British Medical Journal, 2, 372
3.
BrownG. C., EvansT. N. (1967). Serologic evidence of Coxsackievirus aetiology of congenital heart disease. Journal of the American Medical Association, 199, 183
4.
BrownG. C. (1970). Maternal virus infection and congenital anomalies. A prospective study. Archives of Environmental Health, 21, 362
5.
EichenwaldH. F., ShinefieldH. R. (1963). Antibody production by the human foetus. Paediatrics, 63, 870
6.
GristN. R., RossC. A. C., BellE. J., StottE. J. (1966). Diagnostic Methods in Clinical VirologyOxford: Blackwell
7.
HardyJ. B., McCrackenG. H., GilkesonM. R., SeverJ. L. (1969). Adverse fetal outcome following maternal rubella after the first trimester of pregnancy. Journal of the American Medical Association, 207, 2414
8.
JennisF. (1966). A simplified haemagglutination test for toxoplasmosis using pyruvic aldehyde treated cells. Australian Journal of Experimental Biology and Medical Science, 44, 317
9.
LeerhoyJ. (1966). The influence of different media on cell morphology and rubella virus titer in a rabbit cornea cell line (SIRC). Archiv fur die Gesamte Virusforschung, 19, 210
10.
LubchencoL. O., HansmanC., DressierM., BoydE (1963). Intrauterine growth as estimated from liveborn birthweight data at 24 to 42 weeks of gestation. Pediatrics, 32, 793
11.
MacCallumF. O. (1959). Herpes simplex in neonatal period. Acta Virologica, 3, suppl. 17
12.
PlotkinS. A. (1969). In Diagnostic Procedures for Viral and Rickettsial Infections, 4th edition, p. 384. Edited by Lennette and Schmidt. American Public Health Association Inc.
13.
RemingtonJ. S., MillerM. J. (1966). 19S and 7S anti-toxoplasma antibodies in diagnosis of acute congenital and acquired toxoplasmosis. Proceedings of the Society for Experimental Biology and Medicine, 121, 357
14.
RudolphA. J., YowM. D., PhillipsA., DesmondM. M., BlattnerR. J., MelnickJ. L. (1965). Transplacental rubella infection in newly born infants. Journal of the American Medical Association, 191, 843
15.
SabinA. B., FeldmanH. A. (1948). Dyes as micro chemical indicators of a new immunity phenomenon affecting a protozoon parasite (toxoplasma). Science, 108, 660
16.
SieberO. F., FulginitiV. A., BrazieJ., UmlaufH. J. (1966). In utero infection of foetus by herpes simplex virus. Journal of Paediatrics, 69, 30
17.
SternH., BoothJ. C., ElekS. D., FleckD. G. (1969). Microbial causes of mental retardation; the role of prenatal infections with cytomegalovirus, rubella virus, and toxoplasma. Lancet, 2, 443
18.
StewartG. L., ParkmanP. D., HoppsH. E., DouglasR. D., HamiltonJ. P., MeyerH. M.Jr. (1967). Rubella-virus haemagglutination inhibition test. New England Journal of Medicine, 276, 554