Lipoprotein lipase activity has been measured in both pre- and post-heparin plasma samples from 6 patients with Primary Type IV hyperlipoproteinaemia and from 6 normal subjects. Post-heparin lipoprotein lipase activity was of the same order in plasma from both groups. Appreciable activity was, however, noted in plasma collected from the Type IV patients prior to administration of heparin. Lipase activity was minimal in such samples from normal individuals.
Get full access to this article
View all access options for this article.
References
1.
DoleV. P. (1956). A relation between non-esterified fatty acids in plasma and the metabolism of glucose. Journal of Clinical Investigation, 35, 150
2.
EngelbergH. (1958a). Human endogenous plasma lipemia clearing activity, observations in 482 individuals. Journal of Applied Physiology, 13, 375
3.
EngelbergH. (1958b). Human endogenous plasma lipemia clearing activity after intravenous fat emulsions (Lipomul). Journal of Applied Physiology12, 292
4.
EngelbergH. (1958c). Plasma heparin levels in man following intravenous [fat emulsions. Proceedings of the Society of Experimental and Biological Medicine, 97, 304
5.
EngelbergH. (1960). Heparin lipemia clearing reaction and fat transport in man. Summary of available knowledge. American Journal of Clinical Nutrition, 8, 21
6.
FredricksonD. S., LevyR. I., LeesR. S. (1967). Fat transport in lipoproteins—an integrated approach to mechanisms and disorders. New England Journal of Medicine, 276, 273
7.
FredricksonD. S., OnoK., DavisL. I. (1963). Lipolytic activity of post-heparin plasma in hyperglyceridemia. Journal of Lipid Research, 4, 24
8.
KornE. D. (1959). In Methods of Biochemical Analysis, Vol. 7, p. 145. The assay of lipoprotein lipase in vivo and in vitro. New York: Interscience Publications Incorporated
9.
Van HandelE., ZilversmitD. B. (1957). Micro-method for the direct determination of serum triglycerides. Journal of Laboratory and Clinical Medicine (Saint Louis), 50, 152
10.
RobinsonD. S. (1964). In Metabolism and physiological significance of lipids, p. 275. Edited by DawsonR. M. C. and RhodesD. N.London: John Wiley and Sons Ltd.
11.
PearsonS., SernS., McGewokT. H. (1953). Determination of total cholesterol in serum. Analytical Chemistry, 25, 813
12.
RobinsonD. S. (1960). The heparin clearing reaction. American Journal of Clinical Nutrition, 8, 7
13.
RobinsonD. S., FrenchJ. E. (1960). Heparin, the clearing factor lipase and fat transport. Pharmacological Review, 12, 241