Myelolipomas are uncommon lesions of the adrenal gland. Four cases are presented which were found at post-mortem examination and in biopsies received during the last 12 years in the Pathology Departments of the Western General Hospital and of the University of Edinburgh. The pathogenesis of the lesion, which so far has remained an enigma, is discussed in the light of previous reports in the literature. Certain factors emerge which may now be seen to play an important pathogenetic role.
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References
1.
CondonW. B., SafarikL. R., ElziE. P. (1965) Extramedullary haematopoiesis simulating intrathoracic tumour. Archives of Surgery (Chicago), 90, 643
2.
DelarueJ., MonsaingeonA. (1950). Métaplasies myeloides dans la cortico-surrenale des brûles. Comptes rendus des séances de la Société de Biologe (Paris), 144, 777
3.
DodgeO. G., EvansD. M. D. (1956). Haemopoiesis in a presacral fatty tumour (myelolipoma). Journal of Pathology and Bacteriology, 72, 313
4.
FosterJ. B. T. (1958). Primary thoracic myelolipoma. Archives of Pathology (Chicago), 65, 295
5.
GierkeE. (1905). Uber Knochenmarksgewebe in der Nebenniere. Beiträge zur pathologischen Anatomie und zur allgemeinen Pathologie. Suppl. 7, Festschrift fur Professor Julius Arnold, 311
6.
GleaveH. H. (1936). Paravertebral heterotopia of bone marrow in a case of acholuric jaundice. Journal of Pathology and Bacteriology, 42, 538
7.
GoldzieherM. A. (1929). The Adrenals: Their physology, Pathology and diseases, 1st Edition, p. 195. London: J. & A. Churchill
8.
GossmanH. P. (1927). Uber das Vorkommen von Fettgewebe und lipoiden in Epithelkörperchen, Schilddrüse und Nebennieren des Menchen. Virchow's Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, 265, 137
9.
GulzowM. (1948). Durch Pneumoperitoneum nachgewiesener knochenmarkhaltiger, virilisierender Nebenneirenrindentumor. Deutsche medizinische Wochenschrift, 73, 287
10.
HartfallS. J., StewartM. J. (1933). Massive paravertebral heterotopia of bone marrow in a case of acholuric jaundice. Journal of Pathology and Bacteriology, 37, 455
11.
HertzenbergH. (1922). Zur Frage der Heterotopie des Knochenmarkes. Virchow's Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, 239, 145
12.
HofstätterR., SchnitzlerH. (1926). Uber einen ungerwohnlich grossen retroperitonealen Tumor von eigenartigern histologischen Aufbau. Archiv für klinische Chirugie (Berlin), 140, 567
13.
KnoblichR. (1960). Extramedullary hematopoiesis presenting as intrathoracic tumours. Report of a case in a patient with thalassemia minor. Cancer, 13, 462
14.
LyallA. (1935). Massive extramedullary bone marrow formation in a case of pernicious anaemia. Journal of Pathology and Bacteriology, 41, 469
15.
McEuenC. S., SelyeH. (1935). Histologic changes in the adrenals of tumor-bearing rats. American Journal of Medical Sciences, 189, 423
16.
OberlingC. (1929). Les formations myelolipomateuses. Bulletin de l'Association Française pour l'étude du cancer, 18, 234
17.
PaulF. (1928). Knochenmarksbildung in der Nebenniere. Virchow's Archiv für pathologische Anatomie und Physiologie und für klinische Medizin, 270, 785
18.
PlautA. (1958). Myelolipoma in the adrenal cortex. (Myeloadipose structures). American Journal of Pathology, 34, 487
19.
SalaA. M., SteinR. J. (1937). Leukocytic infiltration of the adrenals in malignancy. American Journal of Cancer, 29, 63
20.
SaleebyE. R. (1925). Heterotopia of the bone marrow without apparent cause. American Journal of Pathology, 1, 69
21.
SelyeH., StoneH. (1950). Hormonally induced transformation of adrenal into myeloid tissue. American Journal of Pathology, 26, 211
22.
SnellingC. E., ErbI. H. (1935). Haemorrhage and subsequent calcification of the suprarenal. Journal of Pediatrics (St. Louis), 6, 22
23.
SoósJ. (1930). Zur Nebennieren pathologie VI. Uber Wucherungsherde roten und gelben Knoschenmarks in der Nebenniere. Beiträge zur pathologischen Anatomie und zur allgermeinen Pathologie, 85, 611
24.
SymingtonT. (1969). Functional pathology of the human adrenal gland, 1st Edition, p.84. Edinburgh: E. & S. Livingstone
25.
Van DamC. (1924). Kwaardartige Bijniergezwellen. Dissertation, Amsterdam
26.
WoolleyP. G. (1916). Heteroplastic bone and bone marrow formation associated with tuberculosis in the adrenal. Journal of Laboratory and Clinical Medicine, 1, 502