Long-Term Trimethoprim-Sulphamethoxazole in the Management of Recurrent Urinary Infection

Abstract

Nineteen patients with recurring urinary infections were treated with trimethoprim-sulphamethoxazole in full dosage for 6 months. In 14 (Group I) the upper urinary tract was structurally abnormal and in 5 (group II), the I.V.P. showed no abnormality. In Group I the response rate was initially 70 per cent but had fallen to 30 per cent by the end of the treatment period. In group II all patients responded initially and 4 out of the 5 maintained sterile cultures over the period of treatment. Side effects were not serious and in particular, no haematological anomalies were noted in any patient throughout the 6 months of treatment.