The plasma half-life of antipyrine has been measured in 18 women taking oral contraceptives and in 19 control subjects. The mean half-life in the oral contraceptive group of 13.2±2.0 hr. was significantly prolonged compared to the control value of 10.5±2.5 hours
Get full access to this article
View all access options for this article.
References
1.
BrodieB. B.AxelrodJ. (1950). The fate of antipyrine in man. Journal of Pharmacology and Therapeutics, 98, 97
2.
BrodieB. B.AxelrodJ.SobermanR.Levy'B. B. (1949). The estimation of antipyrine in biological materials. Journal of Biological Chemistry, 179, 25
3.
ConneyA. H. (1967). Pharmacological implications of microsomal enzyme induction. Pharmacological Reviews, 19, 317
4.
CrawfordJ. J.RudofskyS. (1966). Some alterations in the pattern of drug metabolism associated with pregnancy, oral contraceptives and the newly born. British Journal of Anaesthetics, 38, 446
5.
JoriA.BianchettiA.PrestiniP. (1969). Effects of contraceptive agents on drug metabolism. European Journal of Pharmacology, 7, 196
6.
JuchauM. R.FoutsJ. R. (1966). Effect of norethynodrel and progesterone on hepatic microsomal drug-metabolising enzyme systems. Biochemical Pharmacology, 15, 891
7.
KolmodinB.AzarnoffD. L.SjoqvistF. (1969). Effects of environmental factors on drug metabolism: Decreased plasma half-life of antipyrine in workers exposed to chlorinated hydrocarbon insecticides. Clinical Pharmacology and Therapeutics, 10, 638
8.
PreedyJ.AitkenE. (1956). The effect of estrogen on water and electrolyte metabolism. 1. The normal. Journal of Clinical Investigation, 35, 423
9.
SobermanR.BrodieB. B.LevyB. B.AxelrodJ.HollanderJ. (1949). The use of antipyrine in the measurement of total body water in man. Journal of Biological Chemistry, 179, 31
10.
VesselE.PageJ. (1968). Genetic control of drug levels in man: Antipyrine. Science (Washington), 161, 72
11.
VesselE.PageJ. (1969). Genetic control of the phenobarbital-induced shortening of plasma antipyrine half-lives in man. Journal of Clinical Investigation, 48, 2202
