Maximal acid output (M.A.O.) and intrinsic factor (I.F.) of the stomach were measured in 16 patients with polycythaemia vera, 4 of whom had a duodenal ulcer and 2 pernicious anaemia. It was found that, in general, the M.A.O. was significantly less than normal unless an active duodenal ulcer was present when the M.A.O. would reach the usual levels for duodenal ulcer subjects. The gastric I.F. output showed a significant correlation with the M.A.O. These results are discussed in the light of the increased incidence of peptic ulcer in polycythaemia vera and the occasionally reported cases of polycythaemia vera and pernicious anaemia.
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References
1.
AdamsJ. F.GlenA. I. M.KennedyE. H.MackenzieI. L.MorrowJ. J.AndersonJ. R.GrayK. G.MiddletonD. G. (1964). The histological and secretory changes in the stomach in patients with autoimmunity to gastric parietal cells. Lancet, 1, 401
2.
AdamsJ. F.CoxA. G.KennedyE. H.ThompsonJ. (1967). Effect of medical and surgical vagotomy on intrinsic factor secretion. Brit. med. J., 3, 473
3.
AirdI.BentallH. H.MehiganJ. A.RobertsJ. A. F. (1954). The blood groups in relation to peptic ulceration and carcinoma of colon, rectum, breast and bronchus. Brit. med. J., 2, 315
4.
ArdemanS.ChanarinI.DoyleJ. C. (1964). Studies on secretion of gastric intrinsic factor in man. Brit. med. J., 2, 600
5.
ArdemanS.ChanarinI. (1965). Assay of gastric intrinsic factor in the diagnosis of Addisonian pernicious anaemia. Brit. J. Haemat., 11, 295
6.
ArdemanS. (1965). Studies on gastric intrinsic factor. Proc. roy. Soc. Med., 58, 916
7.
BadenochJ.EvansJ. R.RichardsW. C. (1957). The stomach in hypochromic anaemia. Brit. J. Haemat., 3, 175
8.
BingH. J. (1920). Polycythaemia in juxtapyloric ulcer. Ugesk. F. Laeger., lxxxii, 337. ( Abstr. Brit. med. J., 1920, 1, 625
9.
BockusH. L. (1963). Gastroenterology, volume 12nd edition. Philadelphia and London: W. B. Saunders.
10.
BoydW. (1934). The relationship of polycythaemia to duodenal ulcer. Amer. J. med. Sci., 187, 589
11.
BrittonC. J. C. (1963). Disorders of the blood, 9th edition. Edited by BrittonC. J. C.London: J. & A. Churchill
12.
CalabresiP.MeyerO. O. (1959). Polycythaemia vera. 1. Clinical and laboratory manifestations. Ann. intern. Med., 50, 1182
13.
CardW. I.MarksI. H. (1960). The relationship between the acid output of the stomach following ‘maximal’ stimulation and the parietal cell mass. Clin. Sci., 19, 147
14.
ClarkeC. A. (1962). Genetics for the clinician.2nd edition. Oxford: Blackwell
15.
CreanG. P. (1967). Observations on the regulation of the growth of the gastric mucosa. In Gastric secretion mechanisms and control. Oxford and New York: Pergamon Press
16.
DahlJ. D.BlaisdellR. K.BeutlerE. (1959). Gastric ulceration in rats with experimentally-induced polycythaemia. Proc. Soc. exp. Biol. N.Y., 101, 622
17.
DelamoreI. W. (1961). Vitamin B12 metabolism in polycythaemia vera. Clin. Sci., 20, 177
18.
DouglasA. S.RifkindB. M. (1964). Megaloblastic anaemia in association with polycythaemia vera. Scot. med. J., 9, 469
19.
EismanB.SilenW. (1960). Endocrinologic factors in the pathogenesis of peptic ulcer. Adv. intern. Med., 10, 107
20.
EllmanP.BowdlerA. J. (1958). Pernicious anaemia and polycythaemia vera. Postgrad. med. J., 34, 638
21.
EngelA. G.StickneyJ. M. (1962). Pernicious anaemia and polycythaemia vera in one patient. Arch. intern. Med., 109, 168
22.
FountainJ. R. (1957). Treatment of polycythaemia vera with radio-active phosphorus. Brit. med. J., 2, 1335
23.
FriedbergH. D. (1959). The treatment of polycythaemia vera by irradiation. J. Fac. Radiol., 10, 77
24.
GoldbergA.LochheadA. C.DaggJ. H. (1963). Histamine-fast achlorhydria and iron absorption. Lancet, 1, 848
25.
GottliebC.LauK-S.WassermanL. R.HerbertV. (1965). Rapid charcoal assay for intrinsic factor (I.F.) gastric juice unsaturated B12 binding capacity, antibody to I.F., and serum unsaturated B12 binding capacity. Blood, 25, 875
26.
HoedemaekerP. J.AbelsJ.WachtersJ. J.ArendsA.NiewegH. O. (1964). Investigations about the site of production of Castle's gastric intrinsic factor. Lab. Invest., 13, 1394
27.
HumeR.GoldbergA. (1964). Actual and predicted normal red cell volume and plasma volume in primary and secondary polycythaemia. Clin. Sci., 26, 459
28.
HumeR. (1966). Prediction of lean body mass from height and weight. J. clin. Path., 19, 389, 389
29.
HumeR.MelroseA. G. (1967). Relation between maximal acid output of stomach and lean body mass. Brit. med. J., 2, 30
30.
IllingworthC. F. W. (1953). Peptic Ulcer. London: Livingstone
31.
IrvineW. J.DaviesS. H.TeitelbaumS.DelamoreI. W.Wynn-WilliamsA. (1965). The clinical and pathological significance of gastric parietal cell antibody. Ann. N.Y. Acad. Sci., 124, 657
32.
IrvineW. J. (1965). Immunologic aspects of pernicious anaemiaNew Engl. J. Med., 273, 432
JonesF. A. (1957). Clinical and social problems of peptic ulcer. Brit. med. J., 1, 719, 786
35.
KayA. W. (1953). Effect of large doses of histamine on gastric secretion of HCl. An augmented histamine test. Brit. med. J., 2, 77
36.
LawrenceJ. H.BerlinM. F.HuffR. L. (1953). The nature and treatment of polycythaemia. Medicine, 32, 323
37.
LeesF.RosenthalF. D. (1958). Pathogenesis of anaemia after partial gastrectomy. I. Development of anaemia in relation to time, blood loss and diet. Quart. J. Med., 27, 19
38.
LeonardB. J. (1954). Hypochromic anaemia in R.A.F. recruits. Lancet, 1, 899
39.
LindI. (1961). Pernicious anaemia and polycythaemiaActa med. scand., 169, 213
40.
MackayI. R.BurnetF. M. (1963). Autoimmune Disease. Springfield, Ill.: Thomas
41.
MarksI. H.ShumanC. R.ShayH. (1959). Gastric acid secretion in diabetes mellitus. Ann. intern. Med., 51, 227
42.
MollinD. L.RossG. I. M. (1955). Serum vitamin B12 concentrations in leukaemia and in some other haematological conditions. Brit. J. Haemat., 1, 155
43.
MorrisR. S. (1935). Erythremia—a therapeutic suggestion. J. Amer. med. Ass., 101, 200
