Malabsorption is suggested by a variety of clinical features. First suspicions are heightened by deficiency states such as anaemia, weight loss, hypocalcaemia, hypoproteinaemia, hypokalaemia and avitaminosis. Corroboration is most surely obtained by estimation of the daily faecal fat excretion, xylose absorption, or both.
Elucidation of the cause of the malabsorption may require a wide range of investigations.
Get full access to this article
View all access options for this article.
References
1.
AbbottW. O.MillerT. G. (1936). Intubation studies of the human small intestine. 3. A technique for the collection of pure intestinal secretion and for the study of intestinal absorption. J. Amer. med. Ass., 106, 16
2.
AndersonB.BelcherE. H.ChanarinI.MollinD. L. (1960). The urinary and faecal excretion of radioactivity after oral doses of 3H-folic acid. Brit. J. Haemat., 6, 439
3.
AndersonC. M.MesserM.TownleyR. R. W.FreemanM. (1963). Intestinal sucrose and isomaltose intolerance in two siblings. Paediatrics, 31, 1003
4.
AtwellJ. D.DuthieH. L. (1964). The absorption of water, sodium and potassium from the ileum of humans showing the effects of regional enteritis. Gastroenterology, 46, 16
5.
AuricchioS.DahlqvistA.MursetG.PraderA. (1963). Isomaltose intolerance causing decreased ability to utilise dietary starch. J. Pediat., 62, 165
6.
AvioliL. V.McDonaldJ. E.SingerR. A.HennemanP. H. (1965). A new oral isotopic test of calcium absorption. J. clin. Invest., 44, 128
7.
BlankenhornD. H.HirschJ.AhrensE. H.Jr. (1955). Transintestinal intubation: Technic for measurement of gut length and physiologic sampling at known loci. Proc. Soc. exp. Biol. Med., 88, 356
8.
ButterworthC. E.Jr.Perez-SantiagoE.de JesusJ. MartinezSantiniR. (1959). Studies on the oral and parenteral administration of d(+)xylose. New Engl. J. Med., 261, 157
9.
ChanarinI.AndersonB. B.MollinD. L. (1958). The absorption of folic acid. Brit. J. Haemat., 4, 156
10.
ChanarinI.BennettM. C. (1962). Absorption of folic acid and d-xylose as tests of small-intestinal function. Brit. med. J., 1, 985
11.
DahlqvistA. (1961). Determination of maltase and isomaltase activities with a glucose-oxidase reagent. Biochem. J., 80, 547
12.
DurandP. (1958). Latosuria idiopatica in una patiente con diarrea cronica edaciodisi. Minerva pediat., 10, 706
13.
HarrisonG. A. (1937). Chemical methods in clinica medicine, 2nd edition, p. 479. London: Churchill
14.
HelmerO. M.FoutsP. J. (1937). Gastro-intestinal studies. 7. The excretion of xylose in pernicious anaemia. J. clin. Invest., 16, 343
15.
HolzelA.SchwarzV.SutcliffeK. W. (1959). Defective lactose absorption causing malnutrition in infancy. Lancet, 1, 1126
16.
JoverA.GordonR. S.Jr., (1962). A procedure for the quantitative analysis of feces, with special reference to fecal fatty acids. J. Lab. clin. Med., 59, 878
17.
van de KamerJ. H.Ten B. HuininkH.WeijersH. A. (1949). Rapid method for the determination of fat in feces. J. biol. Chem., 177, 347
18.
KaydenH. J.SeniorJ. R.MattsonF. H. (1967). The monoglyceride pathway of fat absorption in man. J. clin. Invest., 46, 1695
19.
LevitanR.FordtranJ. S.BurrowsB. A.IngelfingerF. J. (1962). Water and salt absorption in the human colon. J. clin. Invest., 41, 1754
20.
MillerT. G.AbbottW. O. (1934). Intestinal intubation: A practical technique. Amer. J. med. Sci., 187, 595
21.
ParkerJ. G.RossG. (1960). Incidence of asymptomatic steatorrhoea in adults. Amer. J. dig. Dis., 5, 782
22.
SammonsH. G.MorganD. B.FrazerA. C.MontgomeryR. D.PhilipW. M.PhillipsM. J. (1967). Modification in the xylose absorption test as an index of intestinal function. Gut, 8, 348
23.
SchillingR. F. (1953). Intrinsic factor studies. 2. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J. Lab. clin. Med., 42, 860
24.
WatsonW. C. (1964). Clinical and laboratory studies with castor oil. Ph.D. Thesis
25.
WatsonW. C.DicksonC. (1964). Experience of a new procedure for faecal analysis. Gut, 5, 488
26.
WilsonT. H.WisemanG. (1954). The use of sacs of everted small intestine for the study of the transference of substances from the muscosal to the serosal surface. J. Physiol., 123, 116