The Role of Insulin in the Regulation of Protein Metabolism: A Review

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References

Bancroft

R. W.

Geiger

Hagerty

E. B.

(1951). Nitrogen sparing effect of carbohydrate related to time factor with hypophysectomized and diabetic rats. Endocrinology, 49, 149.

Barker

S. B.

Sweet

J. E.

(1937). Effects of carbohydrate plethora in experimental diabetes. Science, 86, 270.

Black

J. G.

Thomson

W. S. T.

Munro

H. N.

(1956). Unpublished observations.

Bollman

J. L.

Flock

E. V.

Grindley

J. H.

Mann

F. C.

Block

M. A.

(1953). Action of glucose and insulin on free amino acids of the dehepatized dog. Am. J. Physiol., 174, 467.

Cossu

Maestri

(1936). Sul comportamento dell'N aminico in sani e diabetici dopo somministrazione di glucosio e galattosio. Arch. per le sci. Med., 61, 233.

Cuthbertson

D. P.

McCutcheon

Munro

H. N.

(1940). The relationship of carbohydrate metabolism to protein metabolism. II Note on the effect of separation in time of the protein and carbohydrate moities of the diet of the adult and growing rat. Biochem. J., 34, 1002.

Cuthbertson

D. P.

Munro

H. N.

(1939). The relationship of carbohydrate metabolism to protein metabolism. I. The roles of total dietary carbohydrate and of surfeit carbohydrate in protein metabolism. Biochem. J., 33, 128.

Davis

B. L.

Luck

J. M.

(1936). The effect of acetyl choline and other constituents of the suprarenal gland upon blood sugar and amino acids. Am. J. Physiol., 117, 542.

Davis

B. L.

Van Winkle

(1934). The effect of insulin and epinephrine on the amino acid content of the blood of adrenalectomized rabbits. J. biol. Chem., 104, 207.

10.

Engel

F. L.

(1951a). A consideration of the roles of the adrenal cortex and stress in the regulation of protein metabolism. Rec. Progress in Hormone Res., 6, 277.

11.

Engel

F. L.

(1951b). Further observations on the role of the adrenal cortex in the metabolism of amino acids. Endocrinology, 49, 538.

12.

Flock

E. V.

Block

M. A.

Mann

F. C.

Grindley

J. H.

Bollman

J. L.

(1952). The effect of glucose on the amino acids of plasma after total hepatectomy. J. biol. Chem., 198, 427.

13.

Fonn

Berglund

(1922). The retention and distribution of amino acids with especial reference to the urea formation. J. biol. Chem., 51, 395.

14.

Frame

E. G.

Russell

J. A.

(1946). The effects of insulin and anterior pituitary extract on the blood amino nitrogen in eviscerated rats. Endocrinology, 39, 420.

15.

Geiger

Pinsky

J. J.

(1955). Utilization and nitrogen-sparing effect of fructose in alloxan diabetic rats. Metabolism, 4, 166.

16.

Greene

C. H.

Sandiford

Ross

(1923). The amino acid content of the blood in normal and pathologic conditions. J. biol. Chem., 58, 845.

17.

Griffin

A. C.

Luck

J. M.

Kulakoff

Mills

(1954). Further observations on the endocrine regulation of blood amino acids. J. biol. Chem., 209, 387.

18.

Harris

M. M.

Harris

R. S.

(1947). The effect of insulin hypoglycaemia and glucose on various amino acids in blood of mental patients. Proc. Soc. exper. Biol. Med., 64, 471.

19.

Ingle

D. J.

(1951). Parameters of metabolic problems. Rec. Progress in Hormone Res., 6, 159.

20.

Ingle

D. J.

Flores

Torralba

(1956). Level of plasma amino acids in eviscerate rats given glucose and fructose with and without insulin. Diabetes, 5, 53.

21.

Ingle

D. J.

Prestrud

M. C.

Nezamis

J. E.

(1947). The effect of insulin upon the level of blood amino acids in the eviscerated rat as related to the level of blood glucose. Am. J. Physiol., 150, 682.

22.

Ingle

D. J.

Torralba

Flores

(1955). Comparative effects of muscle work and insulin upon plasma amino acids in eviscerated rats. Proc. Soc. exper. Biol. Med., 89, 625.

23.

Ingle

D. J.

Torralba

Flores

(1956). Time response effect of insulin upon the level of plasma amino acids in the functionally eviscerated rat. Endocrinology, 58, 388.

24.

Kerr

S. E.

Krikorian

V. H.

(1929). The effect of insulin on the distribution of non-protein nitrogen in the blood. J. biol. Chem., 81, 421.

25.

Krahl

M. E.

(1953). Incorporation of C14 amino acids into glutathione and protein fractions of normal and diabetic rats tissues. J. biol. Chem. 200, 99.

26.

Lotspeich

W. D.

(1949). The role of insulin in the metabolism of amino acids. J. biol. Chem., 179, 175.

27.

Luck

J. M.

Davis

B. L.

Van Winkle

(1935). Effect of administered glucose upon amino nitrogen content of the blood. Proc. Soc. exper. Biol. Med., 32, 1039.

28.

Luck

J. M.

Morrison

Wilbur

L. F.

(1926). The effect of insulin on the amino acid content of blood. J. biol. Chem., 77, 151.

29.

Luck

J. M.

Morse

S. W.

(1933). The effects of insulin and adrenaline on the amino acid content of blood. Biochem. J., 27, 1648.

30.

Lukens

(1953). The influence of insulin on protein metabolism. Diabetes, 2, 491.

31.

Miller

L. L.

Burke

W. T.

Haft

D. E.

(1955). Interrelations in amino acid and carbohydrate metabolism. Federation Proc, 14, 707.

32.

Milman

A. E.

De Moor

Lukens

(1951). Relation of purified pituitary growth hormone and insulin on regulation of nitrogen balance. Am. J. Physiol., 166, 354.

33.

Mirsky

I. A.

(1938). The influence of insulin on the protein metabolism of nephrectomized dogs. Am. J. Physiol., 124, 569.

34.

Mirsky

I. A.

Heiman

J. D.

Swadesh

(1937). The nitrogen-sparing action of glucose in phlorhizin and pancreatic diabetes. Am. J. Physiol., 119, 376.

35.

Munro

H. N.

(1949). The relationship of carbohydrate metabolism to protein metabolism. III. Further observations on time of carbohydrate ingestion as a factor in protein utilization by the adult rat. J. Nutrition, 39, 375.

36.

Munro

H. N.

(1951). Carbohydrate and fat as factors in protein utilization and metabolism. Physiol. Rev., 31, 449.

37.

Munro

H. N.

Thomson

W. S. T.

(1953). Influence of glucose on amino acid metabolism. Metabolism, 2, 354.

38.

Pasouinelli

Calzolari

(1953). Action of insulin on blood amino nitrogen. Enzymologia, 16, 125.

39.

Powers

H. H.

Reis

(1933). The effect of insulin on amino acid and urea nitrogen in laked and unlaked blood. J. biol. Chem., 101, 523.

40.

Reid

(1936). Insulin and the storage of glycogen in anaesthetized cats. J. Physiol., 87, 121.

41.

Renold

A. E.

Hastings

A. B.

Nesbett

F. B.

Ashmore

(1955). Studies on carbohydrate metabolism in rat liver slices. IV. Biochemical sequence of events after insulin administration. J. biol. Chem., 213, 135.

42.

Russell

J. A.

(1955). Hormonal control of amino acid metabolism. Federation Proc, 14, 696.

43.

Schmidt

E. G.

Eastland

J. S.

(1935). The influence of dextrose ingestion on amino acid nitrogen, urea nitrogen and hemoglobin concentration of the blood. J. lab. clin. Med., 21, 1.

44.

Sinex

F.M.

McMullen

Hastings

A. B.

(1953). The effect of insulin on the incorporation of C14 into the protein of rat diaphragm. J. biol. Chem. 198, 615.

45.

Sokhey

S. S.

Allan

F. N.

(1924). The relationship of phosphates to carbohydrate metabolism. I. Time relationship of the changes in phosphate excretion caused by insulin and sugar. Biochem. J., 18, 1170.

46.

Thomson

W. S. T.

Munro

H. N.

(1955). The relationship of carbohydrate metabolism to protein metabolism. IV. The effect of substituting fat for dietary carbohydrate. J. Nutrition, 56, 139.

47.

Tremoliere

Derache

Lowy

(1955). Données actuelles sur les principaux effets métaboliques de la cortisone. Ann. Nutr. Aliment., 9, 179.

48.

Wolpe

(1924). Uber Aminosäuren im Blutserum, im Liquor cerebrospinalis und in Punktionflüssigkeiten. Münch, med. Woch., 71, 363.