Adenoid cystic carcinoma (ACC) is a malignant neoplasm that arises within secretory glands. It rarely occurs in the lacrimal gland. Kidney metastases are very rare.
Case presentation:
We report a case of a 76-year-old female patient treated with right radical nephrectomy because of the tumour mass of the right kidney. Well-circumscribed, firm, grey mass was found on the lower pole of the kidney. Histologically, tumour was considered to be ACC. Retrospective history data showed ACC of the lacrimal gland surgically treated 14 years before with metastasis to the lung operated seven years before. Our diagnosis was metastatic ACC to the kidney.
Conclusion:
ACC has a remarkable capacity for recurrence. To our knowledge, in the English-speaking area (PubMed), 10 cases of ACC metastatic to the kidney have been described to date, and this is the second reported case of kidney metastasis from primary lacrimal ACC.
SpiroRHHuvasAGStrongEW. Adenoid cystic carcinoma of salivary gland origin. A clinico pathologic study of 242 cases. Am J Surg1974; 128: 512–529.
2.
SahaKJashDBandyopadhyayA. Adenoid cystic carcinoma of the lung with bilateral renal metastases at presentation in a young female. Middle East J Cancer2011; 2: 129–133.
3.
BlöchleCLloydDMIzbickiJR. Successful surgical treatment of liver and kidney metastases 25 years after a primary lacrimal gland tumour. Eur J Surg Oncol1993; 19: 569–572.
4.
LiWHuaWYanFG. Adenoid cystic carcinoma of trachea: a case report and review of literature. Chin Med J2012; 125: 2238–2239.
5.
GoyalJSidanaAO’MalleyM. Large renal metastasis from rare pulmonary neoplasm. Urology2011; 77: 1097–1098.
6.
WangXNQianJYuanYF. Space-occupying lesions of the lacrimal gland at one tertiary eye center in China: a retrospective clinical study of 95 patients. Int J Ophthalmol2012; 5: 208–211.
7.
HerzbergAJBossenEHWaltherPJ. Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management. Cancer1991; 168: 1015–1020.
8.
VranićSBilalovićNLeeLM. PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. Hum Pathol2007; 38: 1425–1431.
9.
TeradaT. Pigmented adenoid cystic carcinoma of the ear skin arising from the epidermis: a case report with immunohistochemical studies. Int J Clin Exp Pathol2012; 5: 254–259.
10.
GuoXFMaoTGuZT. Adenoid cystic carcinoma of the esophagus: report of two cases and review of the Chinese literature. Diagn Pathol2012; 7: 179–179.
11.
FontRLSmithSLBryanRG. Malignant epithelial tumours of the lacrimal gland. A clinicopathological study of 21 cases. Arch Ophthalmol1998; 116: 613–616.
12.
FontRLDel ValleMAvedanoJ. Primary adenoid cystic carcinoma of the conjuctiva arising from the accessory lacrimal glands: a clinicopathologic study of three cases. Cornea2008; 27: 494–497.
13.
SpiroRH. Distant metastasis in adenoid cystic carcinoma of salivary origin. Am J Surg1997; 174: 495–498.
14.
YoonHKMyungALYeongSH. Prognostic factors affecting the clinical outcome of adenoid cystic carcinoma of the head and neck. Jpn J Clin Oncol2007; 37: 805–811.
15.
da CruzPDEde AbreuAFNobukoNI. Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol2006; 42: 139–146.
16.
KaurAHarriganMRMcKeeverPE. Adenoid cystic carcinoma metastatic to the dura: report of two cases. J Neurooncol1999; 44: 267–273.
17.
NaugleTTepperDJHaikBG. Adenoid cystic carcinoma of the lacrimal gland: a case report. Ophtal Plast Reconstr Surg1994; 10: 45–48.
18.
KhanAJDiGiovannaMPRossDA. Adenoid cystic carcinoma: a retrospective clinical review. Int J Cancer2001; 96: 149–158.
19.
WilliamsMDAl-ZubidiNDebnamJM. Bone invasion by adenoid cystic carcinoma of the lacrimal gland: preoperative imaging assessment and surgical considerations. Ophthal Plast Reconstr Surg2010; 26: 403–408.
20.
LeeDACampbellRJWallerRR. A retrospective study of 26 patients with the diagnosis of primary adenoid cystic carcinoma of the lacrimal gland. Ophthalmology1985; 92: 128–134.
21.
ZeidanBAHilalMaAl-GholmyM. Adenois cystic carcinoma of the lacrimal gland metastasising to the liver: a report of a case. World J Surg Oncol2006; 4: 66–66.
22.
LadefogedCBisgaardCPetriJ. Solitary renal metastasis 23 years after extirpation of a bronchial adenoid cystic carcinoma. Scand J Thorac Cardiovasc Surg1984; 18: 245–248.
23.
KalaSPantolaCAgarwalA. Metastatic adenoid cystic carcinoma of kidney masquerading as renal cell carcinoma. Indian J Pathol Microbiol2010; 53: 835–836.
24.
ManorahanMGomezPReyesAM. Metastatic adenoid cystic carcinoma to the kidney in a young woman. Urology2007; 68: 1343.e11–1343.e12.
25.
SantamariaMde LlanoP. Adenoid cystic carcinoma metastatic to the kidney: a case report. Acta Cytol2008; 52: 215–219.
26.
MatthewRMSubhashiniJPonnaiyaJ. Adenoid cystic carcinoma of the external auditory canal with pulmonary, renal and liver metastases. Indian J Cancer1997; 34: 139–142.
