Abstract
(1) Blood-sugar rises and blood-pressure falls as ether anæsthesia progresses.—(2) Blood-sugar is high and blood-pressure low when symptoms of shock are present.—(3) There is some justification for thinking that the pancreatic hormone is deficient as the result of the ketosis produced in connection with ether anæsthesia.—(4) Insulin administration is a successful method of treatment for post-anæsthetic toxic symptoms, which are always associated with a high blood-sugar, and also prevents these from developing. It tends to increase a fallen blood-pressure and reduce a raised blood-sugar during ether anæsthesia.
References
1.
Swan
J. J.
, Archives of Internal Medicine , 1911 , viii , 1 , 58 .
2.
Atkinson
H. V.
Ets
H. N.
, “Chemical Changes of the Blood under the Influence of Drugs, 1, Ether” , Journ. Biol. Chem. , 1922 , lii , 5 .
3.
Mann
Frank C.
, “Investigations of the Relation of Anæsthesia to Hepatic Function” , published in “Current Researches in Anæsthesia and Analgesia” (International Anæsthesia Research Society ), iv , No. 2 , 107 , April, 1925 .
4.
Coburn
Raymond C.
, Journ. Amer. Med. Assoc. , 1924 , lxxxii , 1748 , “Blood-pressure in Operative Surgery and General Anæsthesia.”.
5.
Levin
Gordon
Derrick
, Journ. Amer. Med. Assoc. , 1924 , lxxxii , 1778 .
6.
De Wesselow
O. L. V.
, “The Chemistry of the Blood in Clinical Medicine” , 1924 , 102 .
7.
Ross
E. L.
Davis
L. H.
, “A Difference between Mechanism of Hyperglycæmia produced by Ether and by Chloroform” , Amer. Journ. Physiol. , 1921 , liv , 474 .
8.
Cantarow
A.
Gehret
A. M.
, Journ. Amer. Med. Assoc. , 1931 , xcvi , 939 .
9.
Schulze
F.
, “Narcosis and Acidosis” , Zentralblatt fûr Chirurgie , 1924 , li , 2688 .
10.
Thalhimer
W.
, “Insulin Treatment of Post-operative (Non-diabetic) Acidosis” , Journ. Amer. Med. Assoc. , Aug., 1923 , lxxxi , 383 .
11.
Cullen
G. E.
Austin
J. H.
Kornblum
K.
Robinson
H. W.
, “The Initial Acidosis in Anæsthesia” , Journ. Biol. Chem. , 1923 , lvi , 625 .
12.
Pemberton
R.
Foster
G. R.
, Archives of Internal Medicine , 1920 , xxv , 3 , 243 .
13.
Southwood
A. R.
, “Some Effects of Carbohydrate Deprivation upon Pancreatic Function” , The Med. Journ. of Australia , 1923 , Nov. 3, ii , 460 .
14.
Cannon
W. B.
, Amer. Journ. Physiol. , Dec. 1919 , 1 , 399 .
15.
Hubbard
R. S.
Wright
F. R.
, “Blood Acetone Bodies after Injection of small amounts of Adrenalin Chloride” , Journ. Biol. Chem. , 1921 , xlix , 385 .
16.
Best
Scott
Banting
, Proceedings and Transactions of the Royal Soeiety of Canada , 3rd ser., xvii, Sect. 5, 81 , 1923 .
17.
Best
C. H.
Smith
R. G.
Scott
D. A.
, Amer. Journ. Physiol. , 1924 , lxviii , 161 .
18.
Pemberton
H. S.
Cunningham
L.
, Lancet , 1924 (ii ), 647 .
19.
Thalhimer
W.
Perry
Margaret C.
, “Post-operative Acidosis and its Treatment with Insulin” , published in “Current Researches in Anæsthesia and Analgesia” (The National Anæsthesia Research Society, Inc. ), iii , No. 5, 187 , Oct., 1924 .
20.
Fisher
David
Snell
M. W.
, “Insulin Treatment in Post-operative Non-diabetic Acidosis” , Wisconsin Med. Journ. , 1923 , xxii , 220 .
