The Hæmorrhagic Diathesis

Abstract

The primary purpuras form a single clinical entity.

Variations in the number of platelets can occur without the production of hæmorrhages. These variations are the result of the condition of the capillaries and are not the cause of hæmorrhages. The platelets may vary in any form of purpura, primary or secondary.

The essential cause of the hæmorrhagic state is a defect or increased permeability of the capillary endothelium.

Purpura is allied to urticaria, the Henoch-Schönlein type being an intermediate state.

References

Bedson , Journ. Path, and Bact., 1922, xxv, 94.

Bedson , Lancet, 1924 (ii), 1117.

Brill Rosenthal , Arch. Inter. Med., 1923, xxxii, 939.

Christie , Quart. Journ. Med., 1927, xx, 481.

Clopton , Annals of Surg., 1925, lxxxii, 413.

Dale Laidlaw , Journ. Path, and Bact., 1911–12, xvi, 351.

Duke , Johns Hopkins Hosp. Bull., 1912, xxiii, 144.

Duke , Arch. Inter. Med., 1912, x, 445.

Duke , Arch. Inter. Med., 1913, xi, 100.

10.

Gibbs , Quart. Journ. Med., 1923, xvii, 312.

11.

Giffin , Minnesota Med., 1925, viii, 207.

12.

Foerster , Zeits. f. klin. Med., 1921, xcii, 170.

13.

Frank , Berl. klin. Wochenschr., 1915, et seq.

14.

Glanzmann , Jahrb. f. Kinderheilk., 1918, lxxxviii, 1 and 113.

15.

Hayem , Soc. méd. des Hôpitaux, 1891.

16.

Henoch , Berl. klin. Wochenschr., 1867, 15.

17.

Hess , Proc. Soc. Exp. Biol, and Med., 1916, xiv, 96.

18.

Howell , Amer. Journ. Phys., 1912, xxx, 74.

19.

Jedlicka Altschuller , Acta Med. Scand., 1925, lxiv, 123.

20.

Kaznelson , Deut. Arch. f. klin. Med., 1919, cxxviii, 119.

21.

Leschke Wittkower , Zeits. f. klin. Med., 1925, cii, 733.

22.

Morawitz , Deut. Arch. f. klin. Med., 1904, lxxix, 215.

23.

Osler , Brit. Med. Journ., 1914 (i), 517.

24.

Roskam , Arch. Inter, de Phys., 1922. xx, 290.

25.

Spence , Brit. Journ. Surg., 1928, xv, 466.

26.

Weil , Compt. rend, de la Soc. de Biol., 1921, xxi, 84.

27.

Wright , “The Histogenesis of Blood-plates,” 1910.