Recent research has raised the possibility that learning and memory losses which characterize geriatric senility may be due to increased activity of the caudate nucleus. Belladonna was unsuccessfully tried as a caudate inhibitor. The results indicated that aging leads to a greater learning loss than loss of memory.
ComfortA.Proceedings of the 8th International Congress of Gerontology.Washington, D.C.: Congress, 1969.
3.
EisendorferC., NowlinJ., & WilkieF.Improvement of learning in the aged by modification of autonomic nervous system activity. Science, 1970, 170, 1327–1329.
4.
FeldbergW.Some aspects in pharmacology of central synaptic transmission. Archives Internationales de Physiologie, 1951, 59, 544–560.
5.
GordonP.Rational chemotherapy for aging. Postgraduate Medicine, 1970, 48, 152–155.
6.
GordonP.Molecular approaches to the drug enhancement of deteriorated functioning in the aged. In StrehlerB. L. (Ed.), Advances in gerontological research.New York: Academic Press, 1971. Vol. 3. Pp. 199–248.
7.
GordonP., Tobin, DotyB., & NashM.Drug effects on behavior in aged animals and man: dipheylhydantion and procainamide. Journal of Gerontology, 1968, 23, 434–444.
8.
InglisJ.The scientific study of abnormal behavior.Chicago: Aldine, 1966.
9.
InglisJ., & CairdW.Modified digit spans and memory disorder. Diseases of the Nervous System, 1963, 24, 1–5.
10.
ShuteZ., & LewisP.Cholinergic nervous pathways in the forebrain. Nature, 1961, 189, 332–333.
11.
WyersE. J., & DeadwylerS. A.Duration and nature of retrograde amnesia produced by stimulation of caudate nucleus. Physiology and Behavior, 1971, 6, 840–846.
12.
WyersE. J., PeekeH., WillistonJ., & HerzM.Retroactive impairment of passive avoidance learning by stimulation of the caudate nucleus. Experimental Neurology, 1968, 22, 350–366.