Recombinant DNA technology and techniques for gene insertion into animals have generated promises of animals genetically engineered to be healthy, productive, and sources of novel and/or improved foods and fibre, Transgenic animals have also generated concerns about the production of monsters that will cause ecological catastrophes. Here, current research on the insertion of new genes into livestock is described, and an attempt is made to provide a scientific perspective on the likelihood of either outcome.
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References
1.
BremG., BrenigB., GoodmanH.M., SeltenR.O., GrafF., KruffB., SpringmanK., HondileJ., MeyerJ., WinnakerE.L., and KausslichH. (1985) Production of transgenic mice, rabbits, and pigs by microinjection into pronuclei. Züchthygiene20, 251–252.
2.
ClementsJ.E., WallR.J., NarayanO., HauerD., SchoberR., ShefferD., PowellA., CarruthL.M., ZinkM.C., and RexroadC.E.Jr. (1994) Development of transgenic sheep that express the visna virus envelope gene. Virology200, 370–380.
3.
CrittendenL.B., and SalterD.W. (1990) Expression of retroviral genes in transgenic chickens. Journal of Physiology and Fertility, Supplement 41, 163–171.
4.
CundiffL.V., BishopM.D., and JohnsonR.K. (1993) Challenges and opportunities for integrating genetically modified animals into traditional animal breeding plans. Journal of Animal Science71, 20–25.
5.
HammerR.E., PurselV.G., RexroadC.E.Jr., WallR.J., BoltD.J., EbertK.M., PalmiterR.D., and BrinsterR.L. (1985) Production of transgenic rabbits, sheep and pigs by microinjection. Nature315, 680–683.
6.
KrimpenfortP., RademakersA., EyestoneW., Van der SchansA., Van der BroekS., KookmanP., PootwijkE., PlantenbergG., PieperF., StrijkerR., and De BoerH. (1991) Generation of transgenic dairy cattle using in vitro embryo production. Bio/Technology9, 844–847.
7.
LoD., PurselV, LintonP.J., SandgrenE., BehringerR., RexroadC.E.Jr., PalmiterR.D., and BrinsterR.L. (1991) Expression of mouse IgA by transgenic mice, pigs and sheep. European Journal of Immunology21, 1001–1006.
8.
PalmiterR.D., NorstedtG., GelnasR.E., HammerR.E., and BrinsterR.L. (1983) Metallothionein-Human GH fusion genes stimulate growth of mice. Science222, 809–814.
9.
PurselV.G., and SolomonM.B. (1993) Alteration of carcass composition in transgenic swine. Food Review International9, 423–439.
10.
PurselV.G., and RexroadC.E.Jr. (1993) Status of research with transgenic farm animals. Journal of Animal Science, 71, (Suppl 3), 10–19.
11.
PurselV.G., PinkertC.A., MillerK.F., BoltD.J., CampbellR.G., PalmiterR.D., BristerR.L., and HammerR.E. (1989) Genetic engineering in livestock. Science244, 1281–1288.
12.
RexroadC.E.Jr. (1995) Transgenic livestock in agriculture and medicine. Chemistry and Industry19, 372–375.
13.
RexroadC.E.Jr. (1992) Transgenic technology in animal agriculture. Animal Bio/Technology3, 1–13.
14.
RexroadC.E.Jr., HammerR.E., BehringerR.R., PalmiterR.D., and BrinstenR.L. (1990) Insertion, expression and physiology of growth-regulating genes in ruminants. Journal of Reproduction Text Supplement41, 119–124.
15.
RexroadC.E.Jr, and HawkH.W. (1994) Production of transgenic ruminants. In: PinkertCA (ed.), Transgenic Animals Technology. A Laboratory Handbook. Academic Press, Orlando, USA.
16.
RollinsB.E. (1995) The Frankenstein Syndrome. Cambridge University Press, Cambridge.
17.
WallR.J., and SeidelG. E.Jr. (1992) Transgenic farm animals — a critical analysis. Thieriogenology38, 337–357.
18.
WillmutI., ArchibaldA.L., HarrisS., McClenaghanM., SimonsJ.P., WhitelawC.B.A., and ClarkA.J. (1990) Modification of milk composition. Journal of Reproduction and Fertility Supplement41, 135–146.