The constant need to develop new types of insecticide particularly to overcome the perennial problem of acquired resistance, demands a fundamental understanding of the mode of action of these substances and their precise point of attack on their usual target, the insect's nervous system. For this purpose it is now in many instances unnecessary to investigate the intact nervous system. Cockroach neurones grown in culture possess neuro-transmitter receptor and uptake mechanisms that show responses essentially similar to those in the live insect. They thus provide a means of investigating the mode of action of insecticides under strictly controlled conditions.
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