Viral sepsis is rare, and its real incidence is not known. SARS-CoV-2 infection causes the release of a significant amount of pro-inflammatory cytokines that aggravates interstitial pneumonia and evolves in viral sepsis with prominent hypercoagulability. We believe it is useful and advisable to establish early immunomodulator therapy and the prophylaxis anticoagulant therapy should be rethought.
LinGLMcGinleyJPDrysdaleSB, et al.
Epidemiology and immune pathogenesis of viral sepsis. Front Immunol2018;
9: 2147.
2.
Wu Z and McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA 2020; 323: 1239--1242.
3.
SingerMDeutschmanCSSeymourCW, et al.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).JAMA2016;
315: 801–810.
MehtaPMcAuleyDFBrownM, et al.
Covid-19: consider cytokine storm syndromes and immunosuppression. Lancet2020;
395: 1033–1034.
6.
Luo W, Yu H, Gou J, Li X, et al. Clinical pathology of critical patient with novel coronavirus pneumonia (COVID-19). Preprints 2020, 2020020407.
7.
UmemuraYYamakawaKOguraH, et al.
Efficacy and safety of anticoagulant therapy in three specific populations with sepsis: a meta‐analysis of randomized controlled trials.J Thromb Haemost2016;
14: 518–530.
8.
Tang N, Bai H, Chen X, et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 2020; 18: 1094--1099.
9.
Poston JT, Patel BK and Davis AM. Management of Critically Ill Adults With COVID-19. JAMA 2020; 323: 1839--1841.
10.
Onder G, Rezza G and Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA 2020; 323: 1775--1776.
11.
Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet 2020; 395: 1054--1062.
12.
TangNLiDWangX, et al.
Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost2020;
18: 844–847.
