We report on two cases of homicide by paraquat poisoning. Both cases occurred in children and the common clinical presentations were gastrointestinal ulceration and acute respiratory distress, with pneumomediastinitis. Bullous emphysema was a common autopsy finding. Physicians and pathologists should be aware of these findings, for they are almost diagnostic of acute paraquat poisoning.
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References
1.
FernandoR.Harendera-De-SilvaD.G.AmarasenaT.S. (1990) An unusual case of fatal accidental paraquat poisoning. Forens. Sci. Int.44, 23–6.
2.
ImJ.LeeK.S.HanM.C.KimS.J.KmI.O. (1991) Paraquat poisoning: findings on chest radiography and CT in 42 patients. A.J.R.157, 697–701.
3.
PrattI.S.KeelingP.L.SmithL.L. (1980) The effects of high concentrations of oxygen on paraquat and diquat toxicity in rats. Arch. Toxicol.4, 415–18.
4.
ScherrmannM.J.HouzeP.BismuthC.BourdonR. (1987) Prognostic value of plasma and urine paraquat concentration. Human Toxicol.6, 91–3.
5.
SchoenbergerC.I.RennardS.I.BittermanP.B.FukudaY.FerransV.J.CrystalR.G. (1984) Paraquat-induced pulmonary fibrosis. Role of the alveolitis in modulating the development of fibrosis. Am. Rev. Respir. Dis.129, 168–73.
6.
SmithL.L. (1987) Mechanism of paraquat toxicity in lung and its relevance to treatment. Human Toxicol.6, 31–6.
7.
StephensG.B.MoormeisterK.S. (1997) Homicidal poisoning by paraquat. Am. J. Forens. Med. Pathol.18, 33–9.
WaintrubL.M.TeradaS. L.BeehlerJ.C.AndersonO. B.LeffA. J.RepineE.J. (1990) Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury. J. Appl. Physiol.68, 1755–7.
10.
YamashitaM.MatsuoH.YoshitakaA. (1996) Analysis of 1,000 consecutive cases of acute poisoning in the suburb of Tokyo leading to hospitalization. Vet. Human Toxicol.38, 34–5.