An unusual morphologic change noted in the liver of a 21-year-old male who committed suicide by taking dimenhydrinate is described. The post-mortem interval was two days. Microscopically, there were no marked ante-mortem pathologic changes. In addition to the usual post-mortem autolytic changes, such as disappearance of the hepatic cords and shrinkage of the hepatocytes, conspicuous wavy transformation of the hepatocytes, which has apparently never been reported before, was observed. This change could not be identified as an artifact, and it was assessed to be a type of autolysis.
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