Amounts of drugs found in body fluids and tissues at death are related to the time since ingestion and, within the limits of experimental error, obey Fick's law.
Get full access to this article
View all access options for this article.
References
1.
BeckettA. H.SalmonJ. A.MitchardM. (1969) The relation between blood levels and urinary excretion of amphetamine under controlled acidic and under fluctuating urinary pH values using amphetamine. J. Pharm. Pharmacol.21, 251–258.
2.
BoganJ.RentoulE.SmithH. (1964) Solvent system for TLC separation of acidic and neutral drugs. J. Forensic Sci. Soc.4, 147–149.
3.
BonnischenR.MaehlyA. C.FrankA. (1961) Barbiturate analysis: Method and statistical survey. J. Forensic Sci. 6, 411–443.
4.
CrankJ. (1975) The Mathematics of Diffusion. 2nd ed.Oxford, Clarendon Press.
5.
CurryA. S.SunshineI. (1960) The liver: Blood ratio in cases of barbiturate poisoning. Toxicol. Appl. Pharmacol.2, 602–606.
DoneA. K. (1960) Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ingestion. Pediatrics26, 800–807.
8.
DubostP.PascalS. (1953) Decomposition of drug conjugates. Ann. Pharm. Franc.11, 615–618.
9.
LevyG. (1967) Evidence for non-first-order kinetics of salicylate elimination—a rebuttal. J. Pharm. Sci.56, 1044–1046.
10.
NickollsL. C. (1956) The Scientific Investigation of Crime. London, Butterworth.
11.
OttoF.J. (1856) Alcoholic extraction of drugs from tissues. Ann. Chem. Pharm.C100, 39–43.
12.
RiegelmannS.LooL. C.RowlandM. (1968) Shortcomings in pharmacokinetic analysis by conceiving the body to exhibit properties of a single compartment. J. Pharm. Sci.57, 117–123.
13.
StasJ. S. (1851) Extraction of viscera with alcohol and tartaric acid. Bull. Acad. Roy. Med. Belg.11, 202–210.
14.
StevensH. M. (1967) A rapid general screening method for drugs in post-mortem viscera. J. Forensic Sci. Soc.7, 184–193.
15.
SunshineI. (1963) Use of thin layer chromatography in the diagnosis of poisoning. Am. J. Clin. Path.40, 576–582.
16.
SunshineL.BaumlerJ. (1963) A fatal case of poisoning with amitriptyline. Nature (Lond.)199, 1103–1104.
17.
TeorellT. (1937) Kinetics of distribution of substances administered to the body. Arch. Int. Pharmacodyn.57, 205–224.
18.
ValovP. (1946) Use of sodium tungsten in rapid determination of barbiturates. Ind. & Eng. Chem. Anal. Edn.18, 456–458.
19.
WallsH. J. (1958) Fatal barbiturate poisoning. J. Forensic Med. 5, 27–53.