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Abstract

In order to evaluate driving abilities of each traffic participant, standardised and objective measurement methods are needed. The applicability and value of infrared pupillography as an objective measurement method to indicate possible influence of central nervous acting substances has been demonstrated in former publications. Healthy test subjects (n = 41), as well as persons who were under the influence of drugs and/or medication (n = 105), were exposed to different light stimuli using infrared technology in order to demonstrate the relevance of specific parameters of the pupillary light reflex (PLR) in the field of traffic medicine. Based on former reported results, the statistical examination was extended to further parameters of the PLR, which again confirmed the high value of infrared pupillography as a reliable indicator of previous consumption of drugs and/or medication.

Keywords

expert witness forensic medicine forensic pathology toxicology medical

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References

Pürstl G. Strassenverkehrsordnung [Austrian Road Traffic regulations – With explanatory notes in the light of its legislative history and an overview of the law]. 13th ed. Vienna: Manz, 2011.

Lindauer

Siepmann

Oertel

. Pharmacokinetic/pharmacodynamic modelling of venlafaxine: pupillary light reflex as a test sytem for noradrenergic effects. Clin Pharmacokinet 2008; 47: 721–731.

Wilhelm

. Clinical applications of pupillography. J Neuroophthalmol 2003; 23: 42–49.

Ostrin

Glasser

. The effects of phenylephrine on pupil diameter and accomodation in rhesus monkeys. Invest Ophthalmol Vis Sci 2004; 45: 215–221.

Wilhelm

. The pupil. Curr Opin Neurol 2008; 21: 36–42.

Bergamin

Kardon

. Latency of the pupil light reflex: sample rate, stimulus intensity, and variation in normal subjects. Invest Ophthalmol Vis Sci 2003; 44: 1546–1554.

Murillo

Crucilla

Schmittner

. Pupillometry in the detection of concomitant drug use in opioid-meintained patients. Methods Find Exp Clin Pharmacol 2004; 26: 271–275.

Volpe

Plotkin

Maguire

. Portable pupillography of the swinging flashlight test to detect afferent pupillary defects. Ophthalmology 2000; 107: 1913–1922.

Monticelli

Hitzl

Keller

. Pupil function as a parameter for assessing impairment of the central nervous system from a traffic-medicine perspective. Jpn J Legal Med 2008; 62: 145–145.

10.

Monticelli

Tutsch-Bauer

Hitzl

. Pupil function as a parameter for assessing impairment of the central nervous system from a traffic-medicine perspective. Legal Med 2009; 11: 331–332.

11.

Monticelli

Priemer

Hitzl

. Pupil function as an indicator for being under the influence of central nervous acting substances from a traffic-medicine perspective. Med Sci Law 2010; 50: 75–83.

12.

Hill

Lewicki

. Statistics methods and applications, Tulsa, OK: StatSoft, 2006.

13.

Alexandridis

. Pupillographie. Anwendungsmöglichkeiten als objektive Untersuchungsmethode der Netzhautsinnesfunktion, Heidelberg: Hüthing, 1971.

14.

Müller-Jensen

Hagenah

. Untersuchungen zur Variabilität des phasischen Pupillenlichtreflexes. J Neurol 1976; 212: 123–132.

15.

Verster

Veldhuijzen

Volkerts

. Effects of an opioid (Oxycodone/Paracetamol) and an NSAID (Bromfenac) on driving ability, memory functioning, psychomotor performance, pupil size, and mood. Clin J Pain 2006; 22: 499–504.

16.

Priemer F and Sachs H. The compact integrated pupillograph CIP (AMTech) – its value on detection of psychophysical disorder caused by drugs, Abstract 219. 15th International Conference on Alcohol, Drugs, and Traffic Safety, Stockholm, 2000.

17.

Loewenfeld IE. The Pupil. Anatomy, physiology, and clinical applications. Boston: Butterworth Heinemann, 1999.

18.

Wilhelm

. Pupillenreaktionen – Pupillenstörungen, Stuttgart: Kohlhammer, 1991.

19.

Priemer F, Büchler J, Schwab M, et al. Pupillenfunktion unter akuter MDE-Wirkung. BASt M 152. In: German society of traffic medicine, 32nd annual meeting (ed R Mattern and D Krause), 2003, pp.143–146.

20.

Ellis

. The pupillary light reflex in normal subjects. Br J Ophthalmol 1981; 65: 754–759.

Pupil function as an indicator of being under the influence of central nervous system-acting substances from a traffic-medicine perspective – Part II

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