Mass Production of Human “Embryoid” Cells from Developmentally Frozen Embryos: Is It Ethical?

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References

Boland

Michael J.

Hazen

Jennifer L.

Nazor

Kristopher L.

Rodriguez

Alberto R.

Martin

Greg

Kupriyanov

Sergey

Baldwin

Kristin K.

. 2012 “Generation of Mice Derived from Induced Pluripotent Stem Cells.” Journal of Visualized Experiments 69:e4003. doi: 10.3791/4003.

Burke

William J.

Pullicino

Patrick

Richard

Edward J.

. 2007. “The Biological Basis of the Oocyte Assisted Reprogramming (OAR) Hypothesis: Is It an Ethical Procedure for Making Embryonic Stem Cells?” The Linacre Quarterly 47:204–12.

de Lázaro

Irene

Cossu

Giulio

Kostarelos

Kostas

. 2017. “Transient Transcription Factor (OSKM) Expression is Key towards Clinical Translation of In Vivo Cell Reprogramming” EMBO Molecular Medicine 9:733–36.

Hermerén

Göran

. 2018. “Ethics and Reprogramming: Ethical Questions after the Discovery of iPS Cells.” https://www.eurostemcell.org/ethics-and-reprogramming-ethical-questions-after-discovery-ips-cells.

Holden

Constance

Vogel

Gretchen

. 2004. “A Technical Fix for an Ethical Bind?” Science 306:2174–76. doi: 10.1126/science.306.5705.2174.

Merriam Webster Medline Plus Medical Dictionary. 2019. “Totipotent; Extraembryonic.” http://c.merriam-webster.com/medlineplus/totipotent.

Rivron

Nicolas

Pera

Martin

Rossant

Janet

Arias

Alfonso Martinez

Zernicka-Goetz

Magdalena

Jianping

Brink

Susanne van den

, et al. 2018. “Debate Ethics of Embryo Models from Stem Cells.” Nature 564:183–85. doi: 10.1038/d41586-018-07663-9.

Srivastava

Deepak

DeWitt

Natalie D.

. 2016. “In Vivo Cellular Reprogramming: The Next Generation.” Cell 166:1386–1396. doi: 10.1016/j.cell.2016.08.055.

Takahashi

Kouhei

Yamanaka

Shinya

. 2006. “Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors.” Cell 126:663–76. doi: 10.1016/j.cell.2006.07.024.

10.

USCCB (US Conference of Catholic Bishops Department of Communications). 2007. “Women for Faith and Family 2007. Stem Cell Breakthrough Advances Science without Ethical Landmines, Says Cardinal.” http://archive.wf-f.org/USCCB_1107StemCells.html.

11.

Vogel

Gretchen

Holden

Constance

. 2007. “Field Leaps Forward with New Stem Cell Advances.” Science 318:1224–25.

12.

Wade

Nicholas

. 2007. “Biologists Make Skin Cells Work Like Stem Cells.” New York Times, June 6, p. 1.

13.

Weiss

Rick

. 2007. “Stem Cell Work Hits Milestones.” St Louis Post-Dispatch, November 21: A001.

14.

Wernig

Marius

Meissner

Alexander

Foreman

Robert

Brambrink

Tobias

Maurice

Hochedlinger

Konrad

Bernstein

Bradley E.

Jaenisch

. 2007. “In Vitro Reprogramming of Fibroblasts into a Pluripotent Es-cell-like State.” Nature 448:318–24.

15.

Zheng

Xufeng

Xue

Shao

Yue

Wang

Sicong

Esfahani

Sajedeh Nasr

Zida

Muncie

Jonathon M.

, et al. 2019. “Controlled Modeling of Human Epiblast and Amnion Development Using Stem Cells.” Nature 573:421–25. doi: 10.1038/s41586-019-1535-2.

16.

Zheng

Y. L.

2016. “Some Ethical Concerns about Human Induced Pluripotent Stem Cells.” Science and Engineering Ethics 22:1277–84.