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Abstract

In order to determine whether weight loss is a core symptom or secondary manifestation of Alzheimer's disease, we analyzed weight change in 81 outpatients with Alzheimer's disease. During a mean 2.9 years of observation, the mean absolute weight loss was 1.9 ± 0.8 kg, and the mean weight loss per year was 0.7 ± 0.3 kg. Although statistically significant (P < .05), the mean absolute weight loss was only 3% of initial body weight. Data analyses revealed that weight change was significantly (P < .0001) correlated with decreased independence in self-feeding. Weight change was not related to duration of dementia, clinical measures of dementia severity, psychiatric symptoms, or medications. These observations support the view that weight loss is a consequence of Alzheimer's disease and does not reflect specific brain lesions. (J Geriatr Psychiatry Neurol 1993;1:34–38).

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Weight Loss in Alzheimer's Disease

Abstract

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