Abstract
Use of large animal models is a powerful approach in the development of advanced or improved treatments for human patients. However, the high cost and interdisciplinarity of large animal experimental protocols are key reasons why this type of research rarely spreads beyond the confines of the large and well-endowed facilities that have the equipment and personnel resources for research and training. In a noteworthy break with this stereotype, Li and colleagues demonstrate how large animal model research can be advanced even in the absence of powerful support structures. Specifically, Li and colleagues demonstrate how video laryngoscopy can be used to guide urethral catherization in female minipigs. On the surface this may not appear to be a big deal. In fact, in some institutions setting a catheter may not even be perceived as something that ever could be a problem. Yet, everybody that has tried will know from experience that it requires patience, a lot of practice and skilled supervision to become proficient in setting catheters without visualization. From aiding animal model research for many years, I know that most students and colleagues quickly give up on the blind approach that relies on palpation to guide placement of the catheter. In large research institutions, this is not much of an issue as there are always experienced colleagues that can step in and serve as backup if the catheter needs to be set under time pressure. However, everywhere else a lack of effective methods for visualization increases the risk for the animals and creates unnecessary hurdles in the advancement of protocols. It is this latter aspect that makes the report by Li and colleagues so valuable. Not being bound by corporate rules, or ignorance, Li and colleagues freely share their struggles and ultimate solution. Their use of video laryngoscopy to guide bladder catheterization in is an original addition to the toolkit of researchers that care about the improvement and availability of large animal models.
