Research on biological embedding of the social environment has been expedited by increased availability of biomarkers. Recently, this arsenal of measures has been expanded to include epigenetic clocks that indicate in years the extent to which an individual is older or younger than their chronological age. These measures of biological aging, especially GrimAge, are robust predictors of both illness and time to death. Importantly for sociologists, several studies have linked social conditions to these indices of aging. The present study extends this research using longitudinal data from a sample of 223 black women participating in the Family and Community Health Study. We find that changes in income and living arrangements over an 11-year period predict changes in speed of biological aging. These results provide further support for the idea that epigenetic aging is a mechanism whereby social conditions become biologically embedded. The utility of epigenetic clocks for sociological studies of health are discussed.
AuNicoleJohnstonDavid W. 2014. “Self-assessed Health: What Does It Mean and What Does It Hide?” Social Science and Medicine121:21–28.
3.
BaileyZinzi A.KrigerNancyAgenorMadinaGravesJamineLinosNataliaBassettMary T. 2017. “Structural Racism and Health Inequalities in the USA: Evidence and Interventions.” The Lancet386:1453–63.
4.
BellChristopher G.LoweRobertAdamsPeter D.BaccarelliAndrea A.BeckStephanBellJordana T.ChristensenBrock C., et al2019. “DNA Methylation Aging Clocks: Challenges and Recommendations.” Genome Biology20(1):249. doi:10.1186/s13059-019-1824-y.
5.
BelskyDaniel W.CaspiAvshalomArseneaultLouiseBaccarelliAndreaCorcoranDavid L.GaoXuHannonEiliss, et al2020. “Quantification of the Pace of Biological Aging in Humans through Blood Test, the Dunedinpoam DNA Methylation Algorithm.” eLife9:e54870. doi:10.7554/eLife.54870.
6.
BelskyDaniel W.CaspiAvshalomHoutsRenateCohenHarvey J.CorcoranDavid L.DaneseAndreaHarringtonHonaLee, et al2015. “Quantification of Biological Aging in Young Adults.” Proceedings of the National Academy of Sciences112(30):E4104–10.
7.
BergMark T.LeiMan-KitBeachStevenSimonsRonald L.SimonsLeslie G. 2020. “Childhood Adversities as Determinants of Cardiovascular Disease Risk and Illness Burden in Adulthood.” Journal of Youth and Adolescence49(6):1292–308.
8.
BoksMarco P.MierloHans C.RuttenBart P. F.RadstakeTimothy R. D. J.WitteLot DeGeuzeElbertHorvathSteve, et al2015. “Longitudinal Changes of Telomere Length and Epigenetic Age Related to Traumatic Stress and Post-traumatic Stress Disorder. Psychoneuroendocrinology51: 506–512.
9.
BrodyGene H.MillerGregory E.YuTianyiBeachStephen S. R.ChenEdith. 2016. “Supportive Family Environments Ameliorate the Link between Racial Discrimination and Epigenetic Aging.” Psychological Science27(4):530–41.
10.
CarrDeborah. 2019. Golden Years? Social Inequality in Later-Life. New York, NY: Russell Sage Foundation.
11.
ChenBrian H.MarioniRiccardo E.ColicinoElenaPetersMarjolein J.Ward-CavinessCavinTsaiPei-ChienRoetkerNicholas S., et al2016. “DNA Methylation-Based Measures of Biological Age: Meta-analysis Predicting Time to Death.” Aging8(9):1844–59.
12.
CrystalStephenSheaDennis G.ReyesAdriana M. 2017. “Cumulative Advantage, Cumulative Disadvantage, and Evolving Patterns of Late-Life Inequality.” Gerontologist57(5):910–20.
13.
DanneferDale. 2003. “Cumulative Advantage/Disadvantage and the Life Course: Cross-fertilizing Age and Social Science Theory.” The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences58(5):S327–37.
14.
DeatonAngusPaxonChristina. 1994. “Intertemporal Choice and Inequality.” Journal of Political Economy102(3):437–67.
15.
DowdJennifer BeamToddMegan. 2011. “Does Self-reported Health Bias the Measurement of Health Inequalities in U.S. Adults? Evidence Using Anchoring Vignettes from the Health and Retirement Study.” The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences66(4):478–89.
16.
FahyGregory M.BrookeRobert T.WatsonJames P.GoodZinaidaVasanawalaShreyas S.MaeckerHoldenLeipoldMichael D.LinDavid T. S.KoborMichael S.HorvathSteve. 2019. “Reversal of Epigenetic Aging and Immunoscenescent Trends in Humans.” Aging Cell18(6):e13028. doi:10.1111/acel.13028.
17.
FerraroKennethShippeeTetyana P. 2009. “Aging and Cumulative Inequality: How Does Inequality Get under the Skin?”Gerontologist49(3):333–43.
18.
GeronimusArline T. 2001. “Understanding and Eliminating Racial Inequalities in Women’s Health in the United States: The Role of the Weathering Conceptual Framework.” Journal of the American Medical Women’s Association56(4):133–36.
19.
GeronimusArline T.HickenMargaretKeeneDanyaBoundJohn. 2006. “Weathering and Age Patterns of Allostatic Load Scores among Blacks and Whites in the United States.” American Journal of Public Health96(5):826–33.
20.
GeronimusArline T.HickenMargaretPearsonJay A.SeasholsSarah J.BrownKelly L.CruzTracey D. 2010. “Do U.S. Black Women Experience Stress-Related Accelerated Biological Aging?”Human Nature21(1):19–38.
21.
GibbonsFrederick X.GerrardMegClevelandMichaelWillsThomasBrodyGene H. 2004. “Perceived Discrimination and Substance Use in African American Parents and their Children: A Panel Study.” Journal of Personality and Social Psychology86(4):517–29. doi:10.1037/0022-3514.86.4.517.
22.
HannumGregoryGuinneyJustinZhaoLingZhangLiHughesGuySaddaSriniVasKlotzleBrandy, et al2013. “Genome-Wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates.” Molecular Cell49(2):359–67.
23.
HarrisKathleen M.SchorppKristen M. 2018. “Integrating Biomarkers in Social Stratification and Health Research.” Annual Review of Sociology44:361–86.
HillaryRobertStevensonAnnaMcCartneyDanielCampbellArchieWalkerRosie M.HowardDavid M.RitchieCraig W., et al2020. “Epigenetic Measures of Aging Predict the Prevalence and Incidence of Leading Causes of Death and Disease Burden.” Clinical Epigenetics12(1). doi:10.1186/s13148-020-00905-6.
HorvathSteveRajK. 2019. “DNA Methylation Based Biomarkers and the Epigenetic Clock Theory of Aging.” Nature Reviews Genetics19(6):371–84.
28.
IdlerEllenCartwrightKate. 2018. “What Do We Rate When We Rate Our Health? Decomposing Age-Related Contributions to Self-rated Health. Journal of Health and Social Behavior59(1):74–93.
29.
KaneAlice E.SinclairDavid A. 2019. “Epigenetic Changes during Aging and Their Reprogramming Potential.” Critical Reviews in Biochemistry and Molecular Biology54(1):61–83.
30.
KennedyBrian K.BergerShelley L.BrunetAnneCampisiJudithCuervoAna MariaEpelElissa S.FranceschiClaudio, et al2014. “Geroscience: Linking Aging to Chronic Disease.” Cell159(4):709–13.
31.
KochCarmen M.WagnerWolfgang. 2011. “Epigenetic-Aging-Signature to Determine Age in Different Tissues.” Aging3(10):1018–27.
32.
LeiMan-KitSimonsRonald L.BeachSteven S. R. H.PhilibertRobert A. 2019. “Neighborhood Disadvantage and Biological Aging.” Journals of Gerontology, Series B: Psychological Sciences and Social Sciences74(7):50–59.
33.
LevineMorgan E.LuAkeQuachAustinChenBrian H.AssimesThemistocles L.BandinelliStefaniaHouLifang, et al2018. “An Epigenetic Biomarker of Aging for Lifespan and Healthspan.” Aging10(4):573–91.
34.
LiXiaPlonerAlexanderWangYunzhangMagnussonPatrik KeReynoldsChandraFinkelDeborahPedersenNancy L.JylhäväJuuliaHäggSara. 2020. “Longitudinal Trajectories, Correlations and Mortality Associations of Nine Biological Ages across 20 Years.” eLife9:e51507. doi:10.7554/eLife.51507.
35.
LimEujungGandhiKrupaDavisJamesChenJohn J. 2018. “Prevalence of Chronic Conditions and Multimorbidities in a Geographically Defined Geriatric Population with Diverse Races and Ethnicities.” Journal of Aging and Health30(3):421–44.
36.
LuAke T.QuachAustinWilsonJames G.ReinerAlex P.AvivAbrahamRajKennethHouLifang, et al2019. “DNA Methylation GrimAge Strongly Predicts Lifespan and Healthspan.” Aging11(2):303–27.
37.
MarmotMichael. 2015. The Health Gap: The Challenges of an Unequal World. New York, NY: Bloomsbury.
38.
MasseyDouglas S. 2007. Categorically Unequal: The American Stratification System. New York, NY: Russell Sage Foundation.
39.
MasseyDouglas S. 2017. “Why Death Haunts Black Lives.” Proceedings of the National Academy of Science114:800–802.
40.
MehtaDivyaBruenigDagmarLawfordBruceHarveyWendyCarrillo-RoaTaniaMorrisCharles P.JovanovicTanjaYoungRoss McDBinderElisabeth B.VoiseyJoanne. 2018. “Accelerated DNA Methylaton Aging and Increased Relilience in Veterans: The Biological Cost of Soldiering on.” Neurobiology of Stress8:112–19.
41.
MarioniRiccardo E.ShahSoniaMcRaeAlan F.ChenBrian H.ColicinoElenaHarrisSarah E.GibsonJude, et al2015. “DNA Methylation Age of Blood Predicts All-Cause Mortality in Later Life.” Genome Biology16:25 doi:10.1186/s13059-015-0584-6.
42.
MarioniRiccardoSudermanMatthewChenBrian H.HorvathSteveBandinelliStefaniaMorrisTiffanyBeckStephan, et al2019. “Tracking the Epigenetic Clock across the Human Life Course: A Meta-analysis of Longitudinal Cohort Data.” The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences74(1):57–61.
43.
McCroryCathalFioritoGiovanniHernandezBelindaPolidoroSilviaO'HalloranAisling M.HeverAnnCheallaighCliona Ni, et al2020. “GrimAge Outperforms Other Epigenetic Clocks in the Prediction of Age-Related Clinical Phenotypes and All-Cause Mortality.” The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. doi:10.1093/gerona/glaa286.
44.
MillerGregoryYuTianyiChenEdithBrodyGene (2015). “Self-control Forecasts Better Psychosocial Outcomes but Faster Epigentic Aging in Low-SES Youth.” Proceedings of the National Academy of Sciences12(33):10325–30.
45.
MoffittTerrie E. 2020. “Behavioral and Social Research to Accelerate the Geroscience Translation Agenda.” Ageing Research Reviews63:101146. doi:10.1016/j.arr.2020.101146.
46.
OsbornMegWidomCathy Spatz. 2019. “Do Documented Records and Retrospective Reports of Childhood Maltreatment Similarly Predict Chronic Inflammation?”Psychological Medicine50(14):2406–15.
47.
PavalkoEliza K.CaputoJennifer. 2013. “Social Inequality and Health across the Life Course.” American Behavioral Scientist57(8):1040–56.
48.
PearlinLeonardSchiemanScottFazioElena M.MeersmanStephen C. 2005. “Stress, Health, and the Life Course: Some Conceptual Perspectives.” Journal of Health and Social Behavior46(2):205–19.
49.
PhelanJo C.LinkBruce G.TehranifarParisa. 2010. “Social Conditions as Fundamental Causes of Health Inequalities: Theory, Evidence, and Policy Implications.” Journal of Health and Social Behavior51(S28):S28–40.
50.
QuachAustinLevineMorganTanakaToshikoLuAke T.ChenBrian H.FerrucciLuigiRitzBeate, et al2019. “Epigenetic Analysis of Diet, Exercise, Education, and Lifestyle Factors.” Aging9(2):419–46.
51.
ReubenAaronMoffittTerrieCaspiAvshalomBelskyDaniel W.HarringtonHonaleeSchroederFelixHoganSeanRamrakhaSandhyaPoultoRichieDaneseAndrea. 2016. “Lest We Forget: Comparing Retrospective and Prospective Assessments of Adverse Adulthood Experiences in the Prediction of Adult Health.” Journal of Child Psychology and Psychiatry57(10):1103–12.
52.
RoshandelDelnazChenZhuoCantyAngelo J.BullShelley B.NatarajanRamaPatersonAndrew D.DCCT/EDIC Research Group. 2020. “DNA Methylation Age Calculators Reveal Association with Diabetic Neuropathy in Type 1 Diabetes.” Clinical Epigenetics12(1):52 doi:10.1186/s13148-020-00840-6.
53.
RyanCalen P. 2020. “‘Epigenetic clocks’: Theory and Applications in Human Biology.” Human Biology Toolkit. doi:10.1002/ajhb.23488.
54.
SimonsRonald L.LeiMan-KitBeachSteven S. R. H.BrodyGene H.PhilibertRobertGibbonsFrederick. 2011. “Social Environment, Genes, and Aggression: Evidence Supporting the Differential Susceptibility Perspective.” American Sociological Review76(6):883–912.
55.
SimonsRonald L.LeiMan-KitBeachSteven S. R.PhilibertRobertCutronaCarolynGibbonsFrederickBarrAshley. 2016. “Economic Hardship and Biological Weathering: The Epigenetics of Aging in a U.S. Sample of Black Women.” Social Science and Medicine150:192–200.
56.
SimonsRonald L.LeiMan-KitKlopackEricBeachSteven R. H.GibbonsFrederick X.PhilibertRobert A. 2020. “The Effects of Social Adversity, Discrimination, and Health Risk Behaviors on the Accelerated Aging of African Americans: Further Support for the Weathering Hypothesis.” Social Science and Medicine doi:10.1016/j.socscimed.2020.113169.
57.
WillsonAndrea E.ShueyKim M.ElderGlen H. 2007. “Cumulative Advantage Processes as Mechanisms of Inequality in Life Course Health.” American Journal of Sociology112(6):1886–924.
58.
ZannasAnthony S.ArlothJanineCarrillo-RoaTaniaLuratoStellaRohSimoneResslerKerry J.NemeroffCharles B., et al2015. “Lifetime Stress Accelerates Epigenetic Aging in an Urban, African American Cohort: Relevance of Glucocorticoid Signaling.” Genome Biology 16:266. doi:10.1186/s13059-015-0828-5.
59.
ZhaoWeiAmmousFarahRatliffScottLiuJiaxuanYuMiaoMosleyThomas H.KardiaSharon L. R.SmithJennifer A. 2019. “Education and Lifestyle Factors Are Associated with DNA Methylation Clocks in Older African Americans.” International Journal of Environmental Research and Public Health16(17):3141 doi:10.3390/ijerph16173141.
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