The “War on Drugs” has spawned major research efforts that have led to the discovery of the “opiate receptor” and the development of new narcotic antagonists which may be useful adjuncts in the rehabilitation of chronic opiate addicts. At the moment, these findings are rich with potential applications and potential discovery. The authors review the current state of the art.
Get full access to this article
View all access options for this article.
References
1.
AbelErnestL.1974Drugs and Behavior: A Primer in Neuropsychopharmacology. New York. Wiley.
2.
BlumRichardH. and Associates (eds.). 1969Drugs and Society. Vol. 1. San Francisco. Jossey-Boss.
3.
CowanJonathanFrederickH. Meyers1974“Motivation and Drug Detoxification.”Contemporary Drug Problems3(3):373–402.
4.
DeFleurLoisB.1975“Problems of Research in Response to ‘National Emergencies:’ Drugs and Addiction.” in Social Policy and Sociology. DemerathN. J.IIIOttoLarsenKarlF. Schuessler (Eds.). New York. Academic Press.
5.
EddyNathanB.EveretteL. May1973“The Search for a Better Analgesic.”Science181(4098): 407–414.
6.
GoldsteinAvram1976“Heroin Addiction: Sequential Treatment Employing Pharmocologic Supports.”Archives of General Psychiatry33(March):353–358.
7.
HammondAllenL.1971“Narcotic Antagonists: New Methods to Treat Heroin Addiction.”Science173(3996): 503–506.
8.
LeffS.LeffVera1958From Witchcraft to World Health. New York. Macmillan.
9.
MarxJeanL.1975“Opiate Receptors: Implications and Applications.”Science189(4204): 708–710.
10.
MeyerRogerE.MaryRandallStevenM. MirinDaviesMark1975“Heroin Self-Administration: The Effects of Prior Experience, Environment, and Narcotic Blockade.” Submitted toJournal of Psychiatric Research.
11.
PasternakGavrilW.SolomonH. Snyder1974“Identification of Novel High Affinity Opiate Receptor Binding in Rat Brain.”Nature253(5492): 563–565.
12.
PertCandaceB.AposhianDavidSolomonH. Snyder1974“Phylogenetic Distribution of Opiate Receptor Binding.”Brain Research75:356–361.
13.
PertCandanceB.PasternakGavrilSolomonH. Snyder1973“Opiate Agonists and Antagonists Discriminated by Receptor Binding in the Brain.”Science182(4119): 1359–1361.
14.
PertCandanceB.SolomonH. Snyder1973“The Opiate Receptor: Demonstration in Nervous Tissue.”Science179(4077): 1011–1014.
15.
PertCandanceB.SolomonH. Snyder1974“Opiate Receptor Binding of Agonists and Antagonists Affected Differentially by Sodium.”Molecular Pharmacology10:868–879.
16.
PertCandanceB.SolomonH. Snyder1975“Differential Interactions of Agonists and Antagonists with the Opiate Receptor.” in Opiate Receptor Mechanisms. SolomonH. SnyderMatthysseSteven (Eds.). Cambridge, Mass.MIT Press.
17.
PertAguYakshTony1974“Sites of Morphine Induced Analgesia in the primate Brain: Relation to Pain Pathways.”Brain Research80:135–140.
18.
RayOakleyS.1972Drugs, Society, and Human Behavior. St. Louis. C. V. Mosby.
19.
ResnickRichardB.1976“Prospects, Problems, Side Effects, and Safety of Narcotic Antagonists.”Report to the APA Task Force on Methadone Maintenance and Narcotic Blocking Drugs. Unpublished.
20.
SchorNathan1975“Naltrexone Training Group Presentation.”McLean Hospital.
21.
SnyderSolomonH.1975a“A Model of Opiate Receptor Function with Implications for a Theory of Addiction.” in Opiate Receptor Mechanisms. SolomonH. SnyderMatthysseSteven (Eds.). Cambridge, Mass. MIT Press.
22.
SnyderSolomonH.1975b“Opiate Receptor in Normal and Drug Altered Brain Function.”Nature257:185–189.
23.
SnyderSolomonH.CandaceB. PertGavrilW. Pasternak1974“The Opiate Receptor.”Annals of Internal Medicine81(4): 534–540.
24.
ValentineNancyRogerE. Meyer1976“Narcotic Antagonists: Treatment Tool for Addiction.”Nursing Clinics of North America. (In press.)
25.
WilderAbraham1974a“Dynamics of Drug Dependence.” in Opiate Addictions: Origins and Treatment. FisherSeymourAlfredM. Freedman (Eds.). Washington, D.C.V. H. Winston and Sons.
26.
WilderAbraham1974b“Requirements for Extinction of Relapse Facilitating Variables and for Rehabilitation in a Narcotic Antagonist Treatment Program.” in Narcotic Antagonists: Advances in Biochemical Pharmacology. Vol. 8. BraudeL. S.HarrisL. S.MayE. L. (Eds.). New York. Raven Press.
27.
WiklerAbraham1976“Narcotic Blocking Drugs—Part II.”Report to the APA Task Force on Methadone Maintenance and Narcotic Blocking Drugs. Unpublished.
28.
WilsonAlexanderH.GavrilW. PasternakSolomonH. Snyder1976“Differentiation of Opiate Agonist and Antagonist Receptor Binding by Protein Modifying Reagents.”Nature253(5491): 448–450.
