Vaccine Against Dental Caries—A Personal View

Bowen WH (1965). A bacteriological study of experimental dental caries in monkeys. Int Dent J 15:12-53.

Bowen WH (1969a). The induction of rampant dental caries in monkeys (Macaca irus). Caries Res 3:227-237.

Bowen WH (1969b). A vaccine against dental caries. A pilot study in monkeys (M. irus). Br Dent J 126:159-160.

Bowen WH (1971). The effect of dextranase on caries activity in monkeys (Macaca irus). Br Dent J 131:445-449.

Bowen WH (1976). Relevance of caries vaccine investigations in rodents, primates and humans: Critical assessment. In: Immunologic aspects of dental caries. Bowen WH , Genco R , O'Brien T , editors. Washington, DC: Information Retrieval Inc., pp. 11-21.

Bowen WH , Koch G. ( 1970). Determination of age in monkeys (Macaca irus) on basis of dental development. Lab Animals 4:113-123.

Bowen WH , Cohen B. , Cole MF , Colman G. (1975). Immunisation against dental caries. Br Dent J 139:45-58.

Bowen WH , Schilling K. , Giertsen E. , Pearson S. , Lee SF , Bleiweis A. , et al. (1991). Role of a cell surface-associated protein in adherence and dental caries. Infect Immun 59:4606-4609.

Canby CP , Bernier JL (1942). Bacteriologic and immunologic studies in dental caries: a preliminary report. J Am Dent Assoc 29:606-617.

Clarke JK (1924). Bacterial factor in the aetiology of dental caries . Br J Exp Pathol 5:141-147.

Cole MF , Emilson CG , Hsu SD , Li SH , Bowen WH (1984). Effect of peroral immunization of humans with Streptoccocus mutans on induction of salivary and serum antibodies and inhibition of experimental infection. Infect Immun 46: 703-709.

Critchley P. , Wood JM , Saxton CA , Leach SA (1967). The polymerisation of dietary sugars by dental plaque. Caries Res 1:122-129.

Ellison SA , Mashimo PA , Mandel ID (1960). Immunochemical studies of human saliva. J Dent Res 39:892-898.

Fish EW , Maclean IH (1934). Immunity to the organisms of dental caries. Dent Cosmos 76:837-841.

Fitzgerald RJ , Keyes PH (1960). Demonstration of the etiologic role of streptococci in experimental caries in the hamster. J Am Dent Assoc 61:9-19.

Fitzgerald RJ , Spinell DM , Stoudt T. (1968). Enzymatic removal of artificial plaques. Arch Oral Biol 13:125-128.

Gibbons RJ , Banghart SB (1968). Induction of dental caries in gnotobiotic rats with a levan-forming streptococcus and a streptococcus isolated from subacute bacterial endocarditis. Arch Oral Biol 13:297-308.

Hsu SD , Cole MF ( 1985). Structural integrity of host defense factors in dental plaque. Infect Immun 50:398-402.

Krasse B. (1966). Human streptococci and experimental caries in hamsters. Arch Oral Biol 11:429-436.

Ma JK , Hiatt A. , Hein M. , Vine ND , Wang F. , Stabila P. , et al. (1995). Generation and assembly of secretory antibodies in plants. Science 268:716-719.

Maclean IH (1927). The bacteriology of dental caries. Br Dent J 48:579-584.

Mandel I. (1994). Nature vs. nurture in dental caries. J Am Dent Assoc 125:1345-1351.

McCollum EV , Simmonds N. , Kinney EM , Grieves CJ (1922). The relation of nutrition to tooth development and tooth preservation. I. A preliminary study of gross maxillary and dental defects in two hundred and twenty rats on defective and deficient diets. Johns Hopkins Hosp Bull 33:202-215.

McIntosh J. , James WW , Lazarus-Barlow P. (1922). An investigation into the aetiology of dental caries. I: The nature of the destructive agent and the production of artificial caries. Br J Exp Pathol 3:138-145.

Rosan B, Applebaum B, Golub E, Malamud D, Mandel I (1982). Enhanced saliva-mediated bacterial aggregation and decapased bacterial adhesion in caries-resistant versus caries-susceptible individuals. Infect Immun 38:1056-1059. Russell RR, Beighton D, Cohen B (1982). Immunisation of monkeys (Macaca fascicularis) with antigens purified from Streptococcus mutans. Br Dent J 152:81-84.

Sims W. ( 1970). The concept of immunity in dental caries, general considerations . Oral Surg Oral Med Oral Pathol 30:670-677.

Wallace JS (1901). Experimental demonstration of the cause of the early decay of teeth. J Br Dent Assoc 22:265-269.

Williams NB (1944a). Salivary counts in humans following vaccination with oral lactobacilli. J Dent Res 23:196-197.

Williams NB (1944b). Immunization of human beings with oral lactobacilli . J Dent Res 23:403-411.

Yamashita Y. , Bowen WH , Burne RA , Kuramitsu HK (1993). Role of the Streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model. Infect Immun 61:3811-3817.

Zinner DD , Aran PP , Jablon JM , Brust B. , Saslow MS (1964). Experimental caries induced by human streptococci . J Dent Res 43:859-860.

Dr. Bowen is Chair Emeritus, Department of Dental Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642-8611.