A wide range of different methodologies and measurement techniques has been
employed in laboratories around the world for the study of de- and
remineralization of enamel and dentin in intra-oral systems. These different
approaches are summarized and discussed in relation to the nature of the
different research questions to be studied by means of the intra-oral model.
Get full access to this article
View all access options for this article.
References
1.
ADA HEALTH FOUNDATION
(1986): Proceedings of Scientific Consensus
Conference on Methods of Assessment of the Cariogenic Potential of
Foods, J Dent Res65 (Spec Iss):
1528–1529.
2.
ARENDSJ.; RUBENJ.; and
JONGEBLOEDW.L. (1989):
Dentine Caries In Vivo. Combined Scanning Electron Microscope
and Microradiographic Investigation, Caries
Res23: 36–41.
3.
ARENDSJ., and ten BOSCHJ.J. (1992):
Demineralization and Remineralization Evaluation
Techniques, J Dent Res71 (Spec Iss):
924–928.
4.
BERGMANG., and LINDENL.-AR. (1970):
Microscopic Study of Enamel Decalcification In
Vitro, Swed Dent J63: 173–180.
5.
BRUDEVOLDF.; ATTARZADEHA.; TEHRANIA.; van HOUTEJ.; and RUSSOJ. (1984):
Development of a New Intraoral Demineralization
Test, Caries Res18: 421–429.
6.
BRUDEVOLDF.; TEHRANIA.; and CRUZR. (1982): The
Relationship Among the Permeability to Iodide, Pore Volume, and Intra-oral
Mineralization of Abraded Enamel, J Dent
Res61: 645–648.
7.
CREANORS.L.; MacFARLANET.W.; MACKENZIED.; WEETMAND.A.; STRANGR.; and STEPHENK.W. (1986):
Microbiology and Acid Anion Profiles of Enamel Surface Plaque
from an in situ Caries Appliance, Caries
Res20: 392–397.
8.
CREANORS.L.; STRANGR.; TELFERS.; MacDONALDI.; SMITHM.J.; and STEPHENK.W. (1986):
In Situ Appliance for the Investigation of Enamel De- and
Remineralization, Caries Res20: 385–391.
9.
DIJKMANA.G., and ARENDSJ. (1986):
Mineral Distribution in Human Enamel after in vivo
Demineralization by Dental Plaque. In: Factors
Relating to Demineralisation and Remineralisation of the Teeth,
LeachS.A., Ed.,
Oxford: IRL
Press, pp.
105–114.
10.
EDGARW.M. (1982):
Duration of Response and Stimulus Sequence in the
Interpretation of Plaque pH Data, J Dent
Res61: 1126–1129.
11.
EDGARW.M., and BATEMANR.H. (1990):
Remineralization of Artificial Human Enamel Lesions by
Chewing Sucrose Gum, J Dent Res69: 261, Abst. No. 1217.
12.
EDGARW.M.; GEDDESD.A.M.; JENKINSG.N.; RUGG-GUNNA.J.; and HOWELLR. (1978):
Effects of Calcium Glycero-phosphate and Sodium Fluoride on
the Induction in vivo of Caries-like Changes in Human Dental
Enamel, Arch Oral Biol23: 655–661.
13.
EDGARW.M.; HIGHAMS.M.; MOSSM.C.; HOWARDC.V.; and JOYNERD.J. (1989):
Application of Confocal Microscopy to Study of Enamel
Demineralization, J Dent Res68: 982, Abst. No. 920.
14.
EDGARW.M., and MANNINGR.H. (1990):
Remineralization of Human Enamel Lesions by Chewing Sucrose
Gum; Quantitative Microradiography using Two Methods,
Caries Res24: 405.
15.
FEATHERSTONEJ.D.B. (1983):
Remineralization of Artificial Carious Lesions in vivo and in
vitro. In: Demineralisation and Remineralisation of
the Teeth, LeachS.A., and EdgarW.M., Eds.,
Oxford: IRL
Press, pp.
89–110.
16.
FEATHERSTONEJ.D.B.; CUTRESST.W.; RODGERSB.E.; and
DENNISONP.J. (1982):
Remineralization of Artificial Caries-like Lesions in vivo by
a Self-administered Mouthrinse or Paste, Caries
Res16: 235–242.
17.
FEATHERSTONEJ.D.B.; O'REILLYM.M.; SHARIATIM.; and BRUGLERS. (1986):
Enhancement of Remineralization in vitro and in
vivo. In: Factors Relating to Demineralisation and
Remineralisation of the Teeth, LeachS.A., Ed.,
Oxford: IRL
Press, pp.
23–34.
18.
FEATHERSTONEJ.D.B.; ten CATEJ.M.; SHARIATIM.; and ARENDSJ. (1983):
Comparison of Artificial Caries-like Lesions by Quantitative
Microradiography and Microhardness Profiles, Caries
Res17: 385–391.
19.
GELHARDT.B.F.M., and
ARENDSJ. (1984): In
vivo Remineralization of Artificial Subsurface Lesions in Human Enamel.
1, J Biol Buccale12: 49–57.
20.
GELHARDT.B.F.M., and
ARENDSJ. (1984):
Microradiography of in vivo Remineralized Lesions in Human
Enamel. II, J Biol Buccale12: 59–65.
21.
HALSE., and SIMONSENT.L. (1972):
Histopathology of Experimental in vivo Caries around Silver
Amalgam Fillings, Caries Res6: 16–33.
22.
JANSMAJ.; VISSINKA.; s-GRAVENMADEE.J.; de JOSSELIN de
JONGE.; JONGEBLOEDW.L.; andRETIEFD.H. (1988):
AModel to Investigate Xerostomia-related Dental
Caries, Caries Res22: 357–361.
23.
KOULOURIDEST., and HOUSCHT. (1983):
Hardness Testing and Microradiography of Enamel in Relation
to Intraoral De- and Remineralization. In:
Demineralisation and Remineralisation of the Teeth,
LeachS.A., and EdgarW.M., Eds.,
Oxford: IRL
Press, pp.
255–272.
24.
KOULOURIDEST.; PHANTUMVANITP.; MUNKSGAARDE.C.; and HOUSCHT. (1974): An
Intraoral Model Used for Studies of Fluoride Incorporation in
Enamel, J Biol Buccale3: 185–196.
25.
LARSENM.J., and
FEJERSKOVO. (1989):
Chemical and Structural Challenges in Remineralization of
Dental Enamel Lesions, Scand J Dent Res97: 285–296.
26.
LEACHS.A.; LEEG.T.R.; and EDGARW.M. (1989):
Remineralization of Artificial Caries-like Lesions in Human
Enamel in situ by Chewing Sorbitol Gum, J Dent
Res68: 1064–1068.
27.
LINDENL.-AR. (1968):
Microscopic Observations of Fluid Flow through Enamel in
vitro, Odontol Revy19: 349–356.
28.
MELLBERGJ.R.; CHOMICKIW.G.; MALLOND.E.; and
CASTROVINCEL.A. (1985):
Remineralization in vivo of Artificial Caries Lesions by a
Monofluorophosphate Dentifrice, Caries Res19: 126–135.
29.
NYGAARD ÖSTBYB.; MÖRCHT.; and HALSE. (1957): A
Method for Caries Production on Selected Tooth Surfaces in vivo—Employed in
a Preliminary Study of the Caries-inhibiting Effect of Topically Applied
Agents, Acta Odontol Scand5: 357–363.
30.
ØGAARDB.; RØLLAG.; and HELGELANDK. (1983):
Alkali Soluble and Alkali Insoluble Fluoride Retention in
Demineralized Enamel in vivo, Scand J Dent
Res91: 200–204.
31.
PEARCEE.I.F. (1982):
Effect of Plaque Mineralization on Experimental Dental
Caries, Cones Res16: 460–471.
32.
REINTSEMAH.; SCHUTHOFJ.S.; and ARENDSJ. (1985): An
in vivo Investigation of the Fluoride Uptake in Partially Demineralized
Human Enamel from Several Different Dentifrices, J
Dent Res64: 19–23.
33.
REYNOLDSE.C. (1987):
The Prevention of Sub-surface Demineralization of Bovine
Enamel and Changes in Plaque Composition by Casein in an Intra-Oral
Model, J Dent Res66: 1120–1127.
34.
SILVAM.F. de A.;
BURGESSR.C.; SANDHAMH.J.; and JENKINSG.N. (1987):
Effects of Water-soluble Components of Cheese on Experimental
Caries in Humans, J Dent Res66: 38–41.
35.
SILVAM.F. de A.;
JENKINSG.N.; BURGESSR.C.; and SANDHAMH.J. (1986):
Effects of Cheese on Experimental Caries in Human
Subjects, Caries Res20: 263–269.
36.
SILVERSTONEL.M. (1983):
Remineralisation and Enamel Caries: Significance of Fluoride
and Effect on Crystal Diameters. In:
Demineralisation and Remineralisation of the Teeth,
LeachS.A., and EdgarW.M., Eds.,
Oxford: IRL
Press, pp.
185–205.
37.
SLATERP.J.; MASONS.; and CHISELLD.E. (1986):
In vivo Remineralization: New Methodologies and
Problems. In: Factors Relating to Demineralisation
and Remineralisation of the Teeth, LeachS.A., Ed.,
Oxford: IRL
Press, pp.
233–242.
38.
STRANGR.; DAMATOF.A.; CREANORS.L.; and STEPHENK.W. (1987):
The Effect of Baseline Lesion Mineral Loss on in situ
Remineralization, J Dent Res66: 1644–1646.
39.
STRANGR.; DAMATOF.A.; and STEPHENK.W. (1988):
Comparison of in vitro Demineralization of Enamel Sections
and Slabs, Caries Res22: 348–349.
40.
SUNDSTRÖMF.; FREDRIKSSONK.; MONTANS.;
HAFSTRÖM-BJÖRKMANU.; and STRÖMJ. (1985):
Laser-induced Fluorescence from Sound and Carious Tooth
Substance: Spectroscopic Studies, Swed Dent
J9: 71–80.
41.
ten BOSCHJ.J.; van der MEIH.C.; and
BORSBOOMP.C.F. (1984):
Optical Monitor of in vitro Caries,
Caries Res18: 540–547.
42.
ten CATEJ.M., and
EXTERKATER.A.M. (1986):
Use of the Single-section Technique in Caries
Research, Caries Res20: 525–528.
43.
von der FEHRF.R. (1967): A
Study of Carious Lesions Produced in vivo in Unabraded, Abraded, Exposed and
F-treated Human Enamel Surface, with Emphasis on the X-ray Dense Outer
Layer, Arch Oral Biol12: 797–814.
44.
von der FEHRF.R.; LÖEH.; and THEILADEE. (1970):
Experimental Caries in Man, Caries
Res4: 131–148.
45.
WEFELJ.S.; MAHARRYG.; JENSENM.E.; HAYESP.; and CLARKSONB.H. (1986):
In vivo Demineralization and Remineralization of Enamel and
Root Surfaces. In: Factors Relating to
Demineralisation and Remineralisation of the Teeth,
LeachS.A., Ed.,
Oxford: IRL
Press, pp.
181–190.
46.
WEFELJ.S.; MAHARRYG.J.; JENSENM.E.; and HARLESSJ.D. (1987):
Development of an Intra-oral Single-section Remineralization
Model, J Dent Res66: 1485–1489.