Effect of 45,X/46,XX Mosaicism on Root Morphology of Mandibular Premolars

Abstract

The effect of X chromosome mosaicism on root morphology of mandibular premolars was studied in 14 females with 45,X/46,XX chromosome constitution. Occurrences of two-rooted premolars and the morphology of the roots were examined from orthopantomograms. Six (43%) of the 45,X/46,XX mosaics had two-rooted mandibular premolars. Two-rooted first premolars were found in four (29%) and second premolars in three (21%); in one, all four mandibular premolars were two-rooted. The results indicate that the frequency of two-rooted mandibular premolars was similar in 45,X/46,XX mosaics and in 45,X females, and in both groups significantly higher than in normal 46,XX females. Compared with 45,X females, the 45,X/46,XX mosaics showed a slight tendency toward more simplified root morphology in the first premolars. The findings suggest that the presence of normal 46,XX cells among the defective 45,X cells does not affect the development of the mandibular premolar roots. Furthermore, the results do not support the earlier proposal that the presence of normal 46,XX cells in 45,X/46,XX mosaic individuals would be reflected in gradual normalization of dental development.

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