The Effects of Sucralose on Coronal and Root-surface Caries

Abstract

Sucralose is an intensely sweet, chlorinated carbohydrate structurally similar to sucrose; thus, its cariogenic potential is of great interest. Four groups of 12 Sprague-Dawley rats were infected with Streptococcus mutans (sobrinus), caged in a Konig-Höfer programmed feeding machine, and fed diet 2000 or modified diet to contain sucralose at various concentrations instead of sucrose. Rats fed sucralose diet developed significantly fewer lesions than did the rats fed regular diet 2000. Animals fed diet 2000 also harbored more S. mutans (sobrinus) than did the other groups of animals.

In a concurrent study, desalivated rats were inoculated with S. mutans (sobrinus) and Actinomyces viscosus. They were fed (ad libitum) either diet 2000 (contains 56% sucrose) or diet 2000 minus sucrose plus 93 mg% sucralose. The severity of caries lesions in the sucralose-fed rats after 35 days was significantly less than those in the sucrose-fed rats. The amount of root exposure was the same in both groups. However, root-surface caries did not develop in the sucralose-fed rats. These results show that sucralose is non-cariogenic in rats.

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References

Bhattacharjee, M.K. and Mayer, R.M. (1985): Interaction of Deoxyhalosucrose Derivatives with Dextransucrase, Carbohydr Res 142:277-284.

Bowen, W.H. (1977): Role of Carbohydrates in Dental Caries. In: Proceedings, Sweeteners and Dental Caries, J.H. Shaw and G.G. Roussos , Eds., Sp. Supp. Feeding, Weight and Obesity Abstracts, Washington, D.C.: Information Retrieval, Inc., pp. 147-152.

Bowen, W.H. ; Amsbaugh, S.M. ; Monell-Torrens, S. ; Brunelle, J. ; Kuzmiak-Jones, H. ; and Cole, M.F. (1980): A Method to Assess the Cariogenic Potential of Foodstuffs, J Am Dent Assoc 100:677-681.

Bowen, W.H. ; Pearson, S.K. ; and Young, D.A. (1988): The Effect of Desalivation on Coronal and Root Surface Caries in Rats, J Dent Res 67:21-23.

Bowen, W.H. ; Pearson, S. ; Young, D.A. ; and Thibo-Deau, E. (1985): The Effect of Partial Desalivation on Coronal and Root Surface Caries in the Rat. In: Factors Relating to Demineralisation and Remineralisation of the Teeth, S.A. Leach , Ed., Oxford: IRL Press Ltd., pp. 243-250.

Drucker, D.B. (1983): Comparative Effects of Five Chlorosucrose Analogues on Acidogenicity and Adherence of the Oral Bacterium Streptococcus mutans in vitro, Arch Oral Biol 28:833-837.

Drucker, D.B. and Verran, J. (1980): Comparative Effects of the Substance Sweeteners Glucose, Sorbitol, Sucrose , Xylitol and Trichlorosucrose on Lowering of pH by Two Oral Streptococcus mutans Strains in vitro, Arch Oral Biol 24:965-970.

Edgar, W.M. and Dodds, M.W. (1985): The Effect of Sweeteners on Acid Production in Plaque, Int Dent J 35:18-22.

Green, R.M. and Hartles, R.L. (1969): The Effects of Diets Containing Different Mono- and Disaccharides on the Incidence of Dental Caries in the Albino Rat, Arch Oral Biol 14:235-241.

10.

Keyes, P.H. (1958): Dental Caries in the Molar Teeth of Rats. II. A Method for Diagnosing and Scoring Several Types of Lesions Simultaneously , J Dent Res 37:1088-1099.

11.

Kite, O.W. ; Shaw, J.H. ; and Sognnaes, R.F. (1950): The Prevention of Experimental Tooth Decay by Tube-Feeding, J Nutr 4:89-105.

12.

Konig, K.G. ; Larson, R.H. ; and Guggenheim, B. (1969): A Strain-specific Eating Pattern as a Factor Limiting the Transmissibility of Caries Activity in Rats, Arch Oral Biol 14:91-103.

13.

Rosen, S. ; Doff, R.S. ; App, G. ; and Rotile, J. (1981): A Topographical Scoring System for Evaluating Root Surface Caries. In: Proceedings, Symposium on Animal Models in Cariology, J.M. Tanzer , Ed., Sp. Supp. Microbiology Abstracts, Washington, D.C.: Information Retrieval, Inc., pp. 175-182.

14.

Rugg-Gunn, A.J. and Edgar, W.M. (1985): Sweeteners and Dental Health, Community Dent Health 1:213-223.

15.

Young, D.A. and Bowen, W.H. (1987): The Interaction of Sucralose and Oral Bacteria , J Dent Res 66:328, Abst. No. 1769.