Depressed Eruption Rate of the Rat Maxillary Incisor in a Drug-induced Uncompensated Hemolytic State Model

Abstract

Female rats weighing about 180 g were separated into two groups. One group (A) received phenylhydrazine (PHZ) every other day during three weeks (for induction of an uncompensated hemolytic state), while the control group (C) received saline.

The evidence for the establishment of the uncompensated hemolytic state was obtained by hematocrit value, reticulocyte count, and red-cell-volume-⁵⁹Fe uptake. Body-weight gain (which is a measure of overall body growth rate), body-length gain (which is a measure of longitudinal skeletal growth rate), food intake, and maxillary incisor eruption rate (ER) were significantly depressed in rats of group A during the PHZ-injection period, in relation to rats of group C. These results indicate that anemia and/or associated factors depress ER, along with body growth and skeletal growth.

Get full access to this article

View all access options for this article.

References

Beertsen, W. ; Everts, V. ; and Van Den Hoog, A. (1974): Fine Structure of Fibroblasts in the Periodontal Ligament of the Rat Incisor and their Possible Role in Tooth Eruption, Arch Oral Biol 19:1087-1098.

Berkovitz, B.K.B. (1971): The Effect of Root Transection and Partial Root Resection on the Unimpeded Eruption Rate of the Rat Incisor, Arch Oral Biol 16:1033-1043.

Berkovitz, B.K.B. (1976): Theories on Tooth Eruption. In: The Eruption and Occlusion of Teeth, Colston Papers No. 27, D.G.F. Poole and M.V. Stack , Eds., London: Butterworths , pp. 193-204.

Berkovitz, B.K.B. and Thomas, N.R. (1969): Unimpeded Eruption in the Root-resected Lower Incisor of the Rat with a Preliminary Note on Root Transection, Arch Oral Biol 14 :771-780.

Bryer, L.L. (1957): An Experimental Evaluation of the Physiology of Tooth Eruption, Int Dent J 7:432-478.

Cahill, D.R. and Marks, S.C. (1980): Tooth Eruption: Evidence for the Central Role of the Dental Follicle, J Oral Pathol 9 :189-200.

Elia, R. ; Elgoyhen, A. ; Bugallo, G.D. ; Rio, M.E. ; and Bozzini, C.E. (1985): Effect of Acute Exposure to Reduced Atmospheric Pressures on Body Weight, Food Intake and Body Composition of Growing Rats , Acta Physiol Pharmacol Latinoam 35:311-318.

Giglio, M.J. ; Sanz, A.M. ; Costanzo, A. ; and Bozzini, C.E. (1987): Impeded Eruption Rate of the Maxillary Incisor During Exposure to Different Simulated Altitudes, J Dent Res 66 :1490-1492.

Hara, H. and Ogawa, M. (1976): Erythropoietic Precursors in Mice with Phenylhydrazine-induced Anemia, Am J Hematol 1: 453-458.

10.

Magnusson, B. (1968): Tissue Changes During Molar Tooth Eruption, Trans R Schs Dent Stockh Umeå 13:1-122.

11.

Main, J.H.P. and Adams, D. (1965): Measurements of the Rate of Eruption of the Rat Incisor, Arch Oral Biol 10:999-1008.

12.

Melcher, A.H. and Beertsen, W. (1977): The Physiology of Tooth Eruption. In: The Biology of Occlusal Development, J.A.D. McNamara , Ed., Ann Arbor: University of Michigan, pp. 1-23.

13.

Moxham, B.J. and Berkovitz, B.K.B. (1983): Interactions Between Thyroxine, Hydrocortisone and Cyclophosphamide in their Effects on the Eruption of the Rat Mandibular Incisor, Arch Oral Biol 28:1083-1087.

14.

Schofield, R. (1975): Measurement of Erythropoiesis by Radio-iron Incorporation: Influence of Iron and Cell Kinetic Changes, Exp Hematol 3:22-25.

15.

Wellband, W.A. and Domm, L.V. (1964): Effect of Cortisone, Amputation and Food Restriction on Growth of Rat Maxillary Incisor, Proc Soc Exp Biol Med 116:718-720.