Orthopantomograms of 87 45, X females, 61 first-degree female relatives of these females, and a population sample of 113 normal females and 44 normal males were examined for the occurrence of taurodontism in mandibular molars. In the sample of 45, X females, two showed taurodont lower molars. In one of them, a hypotaurodont second molar was detected, while hypotaurodont third molars were found in the other. Three of the females' relatives and four of the population control females showed taurodontism, three unilaterally and four bilaterally. In all cases, the affected teeth were hypotaurodont. The results suggest that taurodontism occurs in 45, X females with a frequency similar to that in normal females. This result is not in accordance with the hypothesis that low mitotic activity of the chromosomally abnormal cells is an etiological factor in the development of taurodontism. The present findings, together with earlier results, suggest that the gene content of the X chromosome, rather than the amount of heterochromatin, is the cause of taurodontism in individuals with chromosome aneuploidy.
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References
1.
Ackerman, J.L.; Ackerman, A.L.; and Ackerman, A.B. (1973): Taurodont, Pyramidal and Fused Molar Roots Associated with other Anomalies in a Kindred, Am J Phys Anthropol38: 681-694.
2.
Alvesalo, L. (1985): Dental Growth in 47,XYY Males and in Conditions with Other Sex-Chromosome Anomalies. In: The Y Chromosome, Part B: Clinical Aspects of Y Chromosome Abnormalities, A.A. Sandberg, Ed., New York: Alan R. Liss, pp. 277-300.
3.
Alvesalo, L. and Portin, P. (1980): 47,XXY Male: Sex Chromosomes and Tooth Size, Am J Hum Genet32:955-959.
4.
Alvesalo, L. and Tammisalo, E. (1981): Enamel Thickness in 45,X Females' Permanent Teeth , Am J Hum Genet33:464-469.
5.
Alvesalo, L.; Tammisalo, E.; and Therman, E. (1987): 47,XXX Females, Sex-Chromosomes and Tooth Crown Structure, Hum Genet77:345-348.
Alvesalo, L. and Varrela, J. (1990): Taurodontism and Sex Chromosome Aneuploidy: a Study in 47,XXY Males, Hum Biot (submitted for publication).
8.
Blumberg, J.E.; Hylander, W.L.; and Goepp, R.A. (1971): Taurodontism: a Biometric Study, Am J Phys Anthropol34:243-256.
9.
Cure, S.; Boué, J.; and Boué, A. (1974): Growth Characteristics of Human Embryonic Cell Lines with Chromosomal Anomalies, Biomedicine21:233-236.
10.
Feichtinger, C. and Rossivall, B. (1977): Taurodontism in Human Scx Chromosome Aneuploidy , Arch Oral Biol22:327-329.
11.
Filipson, R.; Lindsten, J.; and Almquist, S. (1965): Time of Eruption of the Permanent Teeth, Cephalometric and Tooth Measurements and Sulphation Factor Activity in 45 Patients with the Turner's Syndrome with Different Types of X-Chromosome Aberration, Acta Endocrinol48:91-113.
12.
Gage, J.P. (1978): Taurodontism and Enamcl Hypomaturation Associated with X-Linked Abnormalities, Clin Genet4:159-164.
13.
Hamner, J.E.; Witkop, C.J., Jr.; and Metro, P.S. (1964): Taurodontism, Oral Surg Oral Med Oral Pathol18:409-418.
14.
Jaspers, M.T. (1981): Taurodontism in the Down Syndrome, Oral Surg Oral Med Oral Pathol51:632-636.
15.
Jaspers, M.T. and Witkop, C.J., Jr. (1980): Taurodontism, an Isolated Trait Associated with Syndromes and X-Chromosomal Ancuploidy, Am J Hum Genet32:396-413.
16.
Kari, M.; Alvesalo, L.; and Manninen, K. (1980): Sizes of Deciduous Teeth in 45,X Females, J Dent Res59:1382-1385.
17.
Kirveskari, P. and Alvesalo, L. (1982): Dental Morphology in Turner's Syndrome (45,X females) . In: Teeth: Form, Function, and Evolution, B. Kurten, Ed., New York: Columbia University Press, pp. 298-303.
18.
Komatz, Y.; Tomoyoshi, T.; Yoshida, 0.; Fujimoto, A.; and Yoshi-Take, K. (1978): Taurodontism and Klincfelter's Syndrome, J Med Genet15:452-454.
19.
Lau, E.C.; Mohandas, T.; Slavkin, H.C.; and Snead, M.L. (1988): The Human Amelogcnin Gene is on the X and Y Chromosomes , J Dent Res67:116, Abst. No. 30.
20.
Mayhall, J. and Alvesalo, L. (1988): Molar Crown TraitExpression in Individuals with Sex Chromosome Anomalies, J Dent Res67:116, Abst. No. 27.
21.
Mayhall, J.; Alvesalo, L.; and Townsend, G.C. (1987): Tooth Crown Size in 46,X,i(Xq) Females, J Dent Res66:109, Abst. No. 22.
22.
Orban, B. and Mueller, E. (1929): The Development of the Bifurcation of Multirooted Teeth, J Am Dent Assoc16:297-319.
23.
Shaw, J.C.M. (1928): Taurodont Teeth in South African Races, J Anat62 :476-498.
24.
Simpson, J.L. and Lebeau, M.M. (1981): Gonadal and Statural Determinants on the X Chromosome and Their Relationship to in vitro Studies Showing Prolonged Cell Cycles in 45,X; 46,X,del(X)(p11); 46,X,del(X)(q13); and 46,X,del(X)(q22) Fibroblasts , Am J Obsret Gynecol14:930-940.
Townsend, G.C. and Alvesalo, L. (1985): The Size of Permanent Teeth in Klinefelter (47,XXY) Syndrome in Man, Arch Oral Biol30:83-84.
27.
Townsend, G.C.; Jensen, B.L.; and Alvesalo, L. (1984): Reduced Tooth Size in 45,X (Turner Syndrome) Females , Am J Phys Anthropol65:367-371.
28.
Varrela, J. (1989): Root Morphology of Mandibular Premolars in 45,X Females, Arch Oral Biol (in press).
29.
Varrela, J. and Alvesalo, L. (1988): Taurodontism in 47,XXY Males: an Effect of the Extra X Chromosome on Root Development, J Dent Res67 :501-502.
30.
Varrela, L. and Alvesalo, J. (1989): Taurodontism in Females with Extra X Chromosomes , J Craniofac Genet Dev Biol9:129-133.
31.
Varrela, J.; Larjava, H.; Jarvelainen, H.; Penttinen, R.; Eerola, E.; and Alvesalo, L. (1989): Effect of Sex Chromosome Aneuploidy on Growth of Human Skin Fibroblasts in Cell Culture, Ann Hum Biol16:9-13.
32.
Varrela, J.; Townsend, G.; and Alvesalo, L. (1988): Tooth Crown Size in Human Females with 45,X/46,XX Chromosomes, Arch Oral Biol33 :291-294.
33.
Witkop, C.J., Jr.; Keenan, K.M.; Cervenka, J.; and Jaspers, M.T. (1988): Taurodontism: an Anomaly of Teeth Reflecting Disruptive Developmental Homeostasis, Am J Med Genet4 (Suppl.):85-97.
