The Clinical Effects of a Mouthrinse Containing 0.1% Octenidine

Abstract

The purpose of this three-month clinical trial was to evaluate the effects of a 0.1 % octenidine mouthrinse on plaque, gingivitis, extrinsic dental stain, and the oral soft tissues. A total of 451 adult volunteer subjects was initiated into the study and given baseline dental examinations. The subjects were stratified into two balanced groups according to gender, plaque, and gingivitis scores. The subjects then received a dental prophylaxis and were provided with dentifrice, toothbrushes, and either a mouth rinse containing 0.1 % octenidine dihydrochloride as the active ingredient or a similar placebo mouthrinse. Subjects were instructed to rinse with their assigned product for 30 s twice each day. Examinations were repeated at six weeks (soft-tissue assessment, gingivitis) and three months (soft tissues, plaque, gingivitis, dental stain). The results showed that the group rinsing with 0.1% octenidine had significantly less plaque (39%), gingivitis (50%), and bleeding sites (60%) than the group using the control product, but had significantly higher stain formation and experienced longer prophylaxis times to remove the stain. The oral soft-tissue examinations revealed no differences in the groups in either the numbers or types of lesions noted.

Get full access to this article

View all access options for this article.

References

Emilson, C.G. ; Bowen, W.H. ; Robrish, S.A. ; and Kemp, C.W. (1981): Effect of the Antibacterial Agents Octenidine and Chlorhexidine on the Plaque Flora in Primates, Scand J Dent Res 89:384-392.

Gross, K.B.W. ; Overman, P.R. ; Clark, B.R. ; Eber-Hardt, A. ; and Love, J. (1987): Sanguinarine and Essential Oil Mouthrinses: Effects on Plaque and Gingivitis, Dent Hyg 61 :62-66.

Grossman, E. ; Reiter, G. ; Sturzenberger, O.P. ; De LA Rosa, M. ; Dickinson, T.D. ; Ferretti, G.A. ; Ludlam, G.E. ; and Meckel, A.H. (1986): Six-month Study of the Effects of a Chlorhexidine Mouthrinse on Gingivitis in Adults, J Periodont Res 21 (Suppl 16):33-43.

Lang, N.P. ; Hotz, P. ; Graf, H. ; Geering, A.H. ; Saxer, U.P. ; Sturzenberger, O.P. ; and Meckel, A.H. (1982): Effects of Supervised Chlorhexidine Mouthrinses in Children, J Periodont Res 17:101-111.

Listgarten, M.A. ; Lindhe, J. ; and Hellden, L. (1978): Effects of Tetracycline and/or Scaling on Human Periodontal Disease, J Clin Periodontol 5:246-271.

Löe, H. (1967): The Gingival Index, the Plaque Index, and the Retention Index Systems, J Periodontol 38:610-616.

Löe, H. ; Schiott, C.R. ; Glavind, L. ; and Kerring, T. (1976): Two Years Oral Use of Chlorhexidine in Man. I. General Design and Clinical Effects, J Periodont Res 11:135-144.

Löe, H. ; Theilade, E. ; and Jensen, S.B. (1965): Experimental Gingivitis in Man, J Periodontol 36:177-187.

O'Connor, J.R. ; Paris, D.A. ; and Bailey, D.M. (1980): Octenidine Hydrochloride, An Effective Dental Plaque Inhibitor, AADR Prog & Abst 59:No. 743.

10.

Patters, M.R. ; Anerud, K. ; Trummel, C.L. ; Kornman, K.S. ; Nalbandian, J. ; and Robertson, P.B. (1983): Inhibition of Plaque Formation in Humans by Octenidine Mouthrinse, J Periodont Res 18:212-219.

11.

Patters, M.R. ; Nalbandian, J. ; Nichols, F.C. ; Nie-Krash, C.E. ; Kennedy, J.E. ; Kiel, R.A. ; and Trummel, C.L. (1986): Effects of Octenidine Mouthrinse on Plaque Formation and Gingivitis in Humans, J Periodont Res 21:154-162.

12.

Segreto, V.A. ; Collins, E.M. ; Beiswanger, B.B. ; De LA Rosa, M. ; Isaacs, R.L. ; Lang, N.P. ; Mallatt, M.E. ; and Meckel, A.H. (1986): A Comparison of Mouthrinses Containing Two Concentrations of Chlorhexidine, J Periodont Res 21 (Suppl 16):23-32.

13.

Shern, R.J. ; Little, W.A. ; Kennedy, J.B. ; and Mirth, D.B. (1987): Effects of Octenidine on Dental Plaque and Gingivitis in Monkeys, J Periodontol 58:628-633.

14.

Shern, R.J. ; Monell-Torrens, E. ; Bowen, W.H. ; and Kingman, A. (1980): Effects of Two Recently Developed Antiseptics on Dental Plaque and Caries in Rats, AADR Prog & Abst 59:No. 186.

15.

Siegrist, B.E. ; Gusberti, F.A. ; Brecx, M.C. ; Weber, H.P. ; and Lang, N.P. (1986): Efficacy of Supervised Rinsing with Chlorhexidine Digluconate in Comparison to Phenolic and Plant Alkaloid Compounds, J Periodont Res 21 (Suppl 16):60-73.

16.

Silness, J. and Löe, H. (1964): Periodontal Disease in Pregnancy, Acta Odontol Scand 22:112-135.

17.

Slee, A.M. and O'Connor, J.R. (1983): In vitro Antiplaque Activity of Octenidine Dihydrochloride (WIN 41464-2) Against Preformed Plaques of Selected Oral Plaque-forming Microorganisms , Antimicrob Agents Chemother 23:379-384.

18.

Turesky, S. ; Gilmore, N. ; and Glickman, I. (1979): Reduced Plaque Formation by the Chloromethyl Analogue of Victamine C, J Periodontol 41:41-43.