Alveolar Bone Loss of Senescence-accelerated Mouse (SAM)

Abstract

SAM-R/1/Iw (senescence-accelerated mouse, resistant) and Pl2/Iw (senescence-accelerated mouse, prone) under a conventional environment and eating standard pellets were examined for alveolar bone loss and the presence of periodontitis around maxillary and mandibular molars as a function of age. Neither SAM strain manifested a chronic periodontitis similar to that in humans, and no obvious plaque and calculus were observed. However, in both strains, 15% of M3 was lost after 13 months of age, and alveolar bone loss gradually increased with advancing age. Though there was no significant difference in the incidence of M3 loss between the two strains, P/2/Iw showed a higher alveolar bone loss around all molars than did Rl1/ Iw after one month of age throughout their life span. For Ml, the difference in alveolar bone loss between Pl2/Iw and Rl1/Iw was significant, and it was probably caused by the difference in degree of molar eruption. Other factors, such as occlusal trauma and gingivitis, may play some role in alveolar bone loss.

Get full access to this article

View all access options for this article.

References

Anderson, D.L. (1982): Periodontal Disease and Aging, Gerodontology 1:19-23.

Baer, P.N. and Lieberman, J.E. (1959): Observation on Some Genetic Characteristics of the Periodontium in Three Strains of Inbred Mice, Oral Surg Oral Med Oral Pathol 12:820-829.

Baer, P.N. and Lieberman, J.E. (1960): Periodontal Disease in Six Strains of Inbred Mice , J Dent Res 39:215-225.

Baxter, J.C. (1987): Osteoporosis; Oral Manifestations of a Systemic Disease, Quintessence Int 18:427-429.

Carranza, F.A. ; Gravina, O. ; and Cabrini, R.L. (1965): Periodontal and Pulpal Pathosis in Leukemic Mice , Oral Surg Oral Med Oral Pathol 20:374-379.

Chen, W.-H. ; Hosokawa, M. ; Tsuboyama, T. ; Ono, T. ; Iizuka, T. ; and Takeda, T. (1989): Age-Related Changes in the Temporomandibular Joint of the Senescence Accelerated Mouse (SAM): SAM-P/3 as a New Murine Model of Degenerative Joint Disease, Am J Pathol (in press).

Gibbons, R.J. and Socransky, S.S. (1966): Enhancement of Alveolar Bone Loss in Gnotobiotic Mice Harbouring Human Gingival Bacteria, Arch Oral Biol 11:847-848.

Gilmore, N.D. and Glickman, I. (1959): Some Age Changes in the Periodontium of the Albino Mouse, J Dent Res 38 :1195-1206.

Gottlieb, B. and Orban, B. (1933): Active and Passive Continuous Eruptions of Teeth , J Dent Res 13:214 (Abst.).

10.

Gupta, O.P. and Shaw, J.H. (1956): Periodontal Disease in the Rice Rat. II. Methods for the Evaluation of the Extent of Periodontal Disease, Oral Surg Oral Med Oral Pathol 9:727-735.

11.

Hosokawa, M. ; Kasai, R. ; Higuchi, K. ; Takeshita, S. ; Shimizu, K. ; Hamamoto, H. ; Honma, A. ; Irino, M. ; Toda, K. ; Matsumura, A. ; Matsushita, M. ; and Takeda, T. (1984): Grading Score System: A Method for Evaluation of the Degree of Senescence in Senescence Accelerated Mouse (SAM), Mech Ageing Dev 26:91-102.

12.

Hosokawa, T. ; Hosono, M. ; Higuchi, K. ; Aoike, A. ; Kawai, K. ; and Takeda, T. (1987a): Immune Responses in Newly Developed Short-lived SAM Mice, I. Age-associated Early Decline in Immune Activities of Cultured Spleen Cells, Immunology 62:419-423.

13.

Hosokawa, T. ; Hosono, M. ; Hanada, K. ; Aoike, A. ; Kawai, K. ; and Takeda, T. (1987b): Immune Responses in Newly Developed Short-lived SAM Mice, II. Selectively Impaired Helper Cell Activity in vitro Antibody Response, Immunology 62 :425-429.

14.

Irving, J.T. ; Socransky, S.S. ; and Tanner, A.C.R. (1978): Histological Changes in Experimental Periodontal Disease in Rats Monoinfected with Gram-negative Organisms, J Periodont Res 13:326-332.

15.

Jordan, H.V. (1971): Rodent Model Systems in Periodontal Disease Research , J Dent Res 50 (Suppl): 236-245.

16.

Levy, B.M. (1986): Is Periodontitis a Disease of the Aged?, Gerodontology 5:101-107.

17.

Matsushita, M. ; Tsuboyama, T. ; Kasai, R. ; Okumura, H. ; Yamamuro, T. ; Higuchi, K. ; Higuchi, K. ; Kohno, A. ; Yonezu, T. ; Utani, A. ; Umezawa, M. ; and Takeda, T. (1986): Age-Related Changes in Bone Mass in the Senescence Accelerated Mouse (SAM). SAM-R/3 and SAM-P/6 as New Murine Models for Senile Osteoporosis, Am J Pathol 125:276-283.

18.

Messer, H.H. (1980): Alveolar Bone Loss in a Strain of Mice, J Periodont Res 15:193-205.

19.

Messer, H.H. and Douglas, W.H. (1980): Inhibition by Chlorhcxidine of Alveolar Bone Loss in Mice, J Periodont Res 15 :646-649.

20.

Mitsuoka, A. and Hanada, K. (1987): In vivo Immune Reactivities in Senescence Accelerated Mice (SAM). In: Proceedings of the First SAM Kyoto Symposium, Kyoto: The Council for SAM Research, pp. 11-20.

21.

Page, R.C. and Schroeder, H.E. (1982): Periodontitis in Other Mammalian Animals; Mice . In: Periodontitis in Man and Other Animals, Basel: Karger, Chap. 3, pp. 60-71.

22.

Sashima, M. ; Satoh, M. ; and Suzuki, A. (1987): Incisor Abnormality of Senescence Accelerated Mouse (SAM), Gerodontology 6:145-148.

23.

Takeda, T. ; Hosokawa, M. ; Takeshita, S. ; Irino, M. ; Higuchi, K. ; Matsushita, T. ; Tomita, Y. ; Yasuhira, K. ; Hamamoto, H. ; Shimizu, K. ; Ishii, M. ; and Yamamuro, T. (1981): A New Murine Model of Accelerated Senescence, Mech Ageing Dev 17:183-194.

24.

Tonna, E.A. (1973): Histological Age Changes Associated with Mouse Parodontal Tissues, J Gerontol 28:1-12.