Invited Review: Genetics of Human Salivary Proteins

Abrahamson, M. ; Barrett, A.J. ; Salvesen, G. ; and Grubb, A. (1986): Isolation of Six Cysteine Proteinase Inhibitors from Human Urine, J Biol Chem 261:11282-11289.

Al-Hashimi, I. ; Dickinson, D.P. ; and Levine, M.J. (1988): Purification, Molecular Cloning, and Sequencing of Salivary Cystatin SA-I, J Biol Chem 263:9381-9387.

Anastasi, A. ; Brown, M.A. ; Kembhavi, A.A. ; Nicklin, M.J.H. ; Sayers, C.A. ; Sunter, D.C. ; and Barrett, A.J. (1983): Cystatin, A Protein Inhibitor of Cysteine Proteinases , Biochem J 211:129-138.

Anderson, L.C. ; Kauffman, D.L. ; and Keller, P.J. (1982): Identification of the Pm and PmS Human Parotid Salivary Proteins as Basic Proline-rich Proteins, Biochem Genet 20:1131-1137.

Arneberg, P. (1974): Partial Characterization of Five Glycoprotein Fractions Secreted by the Human Parotid Glands, Arch Oral Biol 19:921-928.

Azen, E.A. (1972): Genetic Polymorphism of Basic Proteins from Parotid Saliva, Science 176:673-674.

Azen, E.A. (1973): Properties of Salivary Basic Proteins showing Polymorphisms, Biochem Genet 9:69-86.

Azen, E.A. (1977): Salivary Peroxidase (SAPX): Genetic Modification and Relationship to the Proline-rich (Pr) and Acidic (Pa) Proteins, Biochem Genet 15:9-29.

Azen, E.A. (1978a): Genetic Protein Polymorphisms in Human Saliva : An Interpretive Review, Biochem Genet 16:79-99.

Azen, E.A. (1978b): Salivary Peroxidase Activity and Thiocyanate Concentration in Human Subjects with Genetic Varients of Salivary Peroxidase , Arch Oral Biol 23:801-805.

Azen, E.A. and Denniston, C.L. (1974): Genetic Polymorphism of Human Salivary Proline-rich Proteins: Further Genetic Analysis, Biochem Genet 12:109-120.

Azen, E.A. and Denniston, C.L. (1980): Polymorphism of Ps (Parotid Size Variant) and Detection of a Protein (PmS) Related to the Pm (Parotid Middle-band) System with Genetic Linkage of Ps and Pm to G1, Db and Pr Genetic Determinants, Biochem Genet 18:483-501.

Azen, E.A. and Denniston, C.L. (1981): Genetic Polymorphism of PIF (Parotid Isoelectric Focusing Variant) Proteins with Linkage to the PPP (Parotid Proline-rich Protein) Gene Complex, Biochem Genet 19:475-485.

Azen, E.A. ; Goodman, P.A. ; and Lalley, P.A. (1985): Human Salivary Proline-rich Protein Genes on Chromosome 12, Am J Hum Genet 37:418-424.

Azen, E.A. ; Hurley, C.K. ; and Denniston, C. (1979): Genetic Polymorphism of the Major Parotid Salivary Glycoprotein (Gl) with Linkage to the Genes for Pr, Db, and Pa, Biochem Genet 17:257-279.

Azen, E.A. ; Kim, H.S. ; Goodman, P. ; Flynn, S. ; and Maeda, N. (1987): Alleles at the PRH1 Locus Coding for the Human Salivary-Acidic Proline-rich Proteins Pa, Db and PIF, Am J Hum Genet 41:1035-1047.

Azen E. A.; Lyons, K.M. ; McGonigal, T. ; Barrett, N.L. ; Clements, L.S. ; Maeda, N. ; Vanin, E.F. ; Carlson, D.M. ; and Smithies, O. (1984): Clones for the Human Gene Complex Coding for Salivary Proline-rich Proteins, Proc Natl Acad Sci USA 81:5561-5565.

Azen, E.A. and Oppenheim, F.G. (1973): Genetic Polymorphism of Proline-rich Human Salivary Proteins, Science 180:1067-1069.

Azen, E.A. and Yu, P.L. (1984a): Genetic Polymorphism of CON1 and CON2 Salivary Proteins Detected by Immunologic and Concanavalin A Reactions on Nitrocellulose with Linkage of CON1 and CON2 Genes to the SPC (Salivary Protein Gene Complex) , Biochem Genet 22:1-19.

Azen, E.A. and Yu, P.L. (1984b): Genetic Polymorphism of Pe and Po Salivary Protein with Probable Linkage of their Genes to the Salivary Protein Gene Complex (SPC), Biochem Genet 22 :1065-1080.

Baker, A.R. and Shine, J. (1985): Human Kallikrein: cDNA Cloning and Sequence Analysis , DNA 4:445-450.

Baig, M.M. ; Winzler, R.J. ; and Rennert, O.M. (1973): Isolation of Mucin from Human Submandibular Secretions , J Immunol 111:1826-1833.

Balekjian, A.Y. and Longton, R.W. (1973): Histones Isolated from Parotid Fluid, Biochem Biophys Res Commun 50:676-682.

Barrett, A.J. ; Fritz, H. ; Grubb, A. ; Isemura, S. ; Jar-Vinen, M. ; Katsunuma, N. ; Machleidt, W. ; Muller-Esterl, W. ; Sasaki, M. ; and Turk, V. (1986a): Nomenclature and Classification of the Proteins Homologous with the Cysteine-Proteinase Inhibitor Chicken Cystatin, Biochem J 236:312.

Barrett, A.J. ; Rawlings, N.D. ; Davies, M.E. ; Machleidt, W. ; Salvesen, G. ; and Turk, V. (1986b): Cysteine Proteinase Inhibitors of the Cystatin Superfamily. In: Proteinase Inhibitors , A.J. Barrett and G. Salvesen , Eds., Amsterdam: Elsevier Science Publishers, pp. 515-569.

Baum, B.J. ; Bird, J.L. ; Millar, D.B. ; and Longton, R.W. (1976): Studies on Histidine-rich Polypeptides from Human Parotid Saliva, Arch Biochem Biophys 177:427-436.

Bennick, A. (1982): Salivary Proline-rich Proteins, Mol Cell Biochem 45:83-99.

Bennick, A. (1987): Structural and Genetic Aspects of Proline-rich Proteins, J Dent Res 66:457-461.

Bennick, A. ; Chau, G. ; Goodlin, R. ; Abrams, S. ; Tus-Tian, D. ; and Madapallimattam, G. (1983): The Role of Human Salivary Acidic Proline-rich Proteins in the Formation of Acquired Dental Pellicle in vivo and their Fate after Adsorption to the Human Enamel Surface, Arch Oral Biol 28:19-27.

Bennick, A. and Connell, G.E. (1971): Purification and Partial Characterization of Four Proteins from Human Parotid Saliva, Biochem J 123:455-464.

Bennick, A. ; McLaughlin, A.C. ; Grey, A.A. ; and Madapallimattam, G. (1981): The Location and Nature of Calcium-binding Sites in Salivary Acidic Proline-rich Proteins, J Biol Chem 256:4741-4746.

Boan, F. and Caeiro, J.L.B. (1988): Salivary Enzyme Polymorphisms (Set, Sgd and AMY ,) in the Galician Population, Hum Hered 38:83-90.

Boat, T.F. ; Wiesman, U.N. ; and Pallavicini, J.C. (1974): Purification and Properties of the Calcium-precipitable Protein in Submandibular Saliva of Normal and Cystic Fibrosis Subjects, Pediatr Res 8:531-539.

Brzin, Z. ; Popovic, T. ; and Turk, V. (1984): Human Cystatin, a New Proteinase Inhibitor of Cysteine Proteinase, Biochem Biophys Res Commun 118:103-109.

Caeiro, J.L.B. ; Boan, F. ; and Carracedo, A. (1987): A Simplified Procedure for Simultaneous Detection of Salivary Proteins and its Application in Paternity Testing, Forens Sci Int 33:47-52.

Carlson, D.M. ; Ann, D.K. ; and Mehansho, H. (1986): Proline-rich Proteins: Expression of Salivary Multigene Families. In: Microbiology, L. Levine , Ed., Washington, D.C.: American Society for Microbiology, pp. 303-306.

Chauncey, H.H. (1961): Salivary Enzymes, J Am Dent Assoc 63:360-368.

Chauncey, H.H. ; Lionetti, F. ; Winer, R.A. ; and Lisanti, V.F. (1954): Enzymes of Human Saliva. I. The Determination, Distribution, and Origin of Whole Saliva Enzymes, J Dent Res 33:321-334.

Degand, P. ; Boersma, A. ; Roussel, P. ; Richet, C. ; and Biserte, G. (1975): The Peptide Moiety of the Region Carrying the Carbohydrate Chains of the Human Parotid Glycoprotein, FEBS Lett 54:189-192.

De Soyza, K. (1978): Polymorphism of Human Salivary Amylase-A Preliminary Communication, Hum Genet 45:189-192.

De Soyza, K. (1982): Determination of Phenotypes of Salivary Amylase in Liquid Saliva and Saliva Stains, Forens Sci Int 20 :1-7.

Dickinson, D.P. ; Ridall, A.L. ; and Levine, M.J. (1987): Human Submandibular Gland Statherin and Basic Histidine-rich Peptide are Encoded by Highly Abundant mRNA's Derived from a Common Ancestral Sequence, Biochem Biophys Res Commun 149:784-790.

Douglass, J. ; Civelli, O. ; and Herbert, E. (1984): Polyprotein Gene Expression: Generation of Diversity of Neuroendocrine Peptides, Ann Rev Biochem 53:665-715.

Eckersall, P.D. and Beeley, J.A. (1981): Genetic Analysis of Human Salivary a-amylase Isozymes by Isoelectric Focusing, Biochem Genet 19:1055-1062.

Ellison, S.A. (1966): Salivary Antigens, J Dent Res 45:644-654.

Ericson, T. and Rundegren, J. (1983): Characterization of a Salivary Agglutinin Reacting with a Serotype C Strain of Streptococcus mutans, Eur J Biochem 133:255-261.

Friedman, R.D. ; Merritt, A.D. ; and Bixler, D. (1971): Immunological and Chemical Comparison of Heterogeneous Basic Glycoproteins in Human Parotid Saliva, Biochim Biophys Acta 230:599-602.

Friedman, R.D. and Merritt, A.D. (1975): Partial Purification and Characterization of a Polymorphic Protein (Pa) in Human Parotid Saliva, Am J Hum Genet 27:304-314.

Friedman, R.D. ; Merritt, A.D. ; and Rivas, M.L. (1975): Genetic Studies of Human Acidic Salivary Protein (Pa), Am J Hum Genet 27:292-303.

Fujimoto, Y. ; Moriya, H. ; and Moriwaki, C. (1973): Studies of Human Salivary Kallikrein, J Biochem 74:239-246.

Fukushima, D. ; Kitamura, N. ; and Nakanishi, S. (1985): Nucleotide Sequence of Cloned cDNA for Human Pancreatic Kallikrein, Biochemistry 24:8037-8043.

Gibbons, R.J. and Hay, D.I. (1988): Human Salivary Acidic Proline-rich Proteins and Statherin Promote the Attachment of Actinomyces viscosus LY7 to Apatitic Surfaces , Infect Immun 56 :439-445.

Goodman, P.A. and Karn, R.C. (1983): Human Parotid Size Polymorphism (Ps): Characterization of Two Allelic Products, Ps 1 and 2, by Limited Proteolysis, Biochem Genet 21:405-416.

Goodman, P.A. ; Yu, P.L. ; Azen, E.A. ; and Karn, R.C. (1985): The Human Salivary Protein Complex (SPC): A Large Block of Related Genes, Am J Hum Genet 37:785-797.

Grubb, A. and Lofberg, H. (1982): Human γ-trace, a Basic Microprotein: Amino Acid Sequence and Presence in the Adenohypophysis, Proc Natl Acad Sci USA 79:3024-3027.

Gugler, E. ; Pallavicini, J.C. ; Swerdlow, H. ; Zipkin, I. ; and Di Sant'Agnese, P.A. (1968): Immunological Studies of Submaxillary Saliva from Patients with Cystic Fibrosis and from Normal Children, J Pediatr 73:548-559.

Hagerman, A.E. and Butler, L.G. (1981): The Specificity of Proanthocyanidin-Protein Interactions , J Biol Chem 256:4494-4497.

Hamon, C.B. and Klebanoff, S.J. (1973): A Peroxidase-mediated Streptococcus mitis-dependent Anti-microbial System in Saliva, J Exp Med 137:438-450.

Hare, E.R. and Verpoorte, J.A. (1985): The Purification of Kallikrein from Human Whole Saliva, Arch Oral Biol 17 :589-595.

Hatton, M.N. ; Loomis, R.E. ; Levine, M.J. ; and Tabak, L.A. (1985): Masticatory Lubrication. The Role of Carbohydrate in the Lubricating Property of a Salivary Glycoprotein-Albumin Complex, Biochem J 230:817-820.

Hay, D.I. (1973): The Isolation from Human Parotid Saliva of a Tyrosine-rich Acidic Peptide which Exhibits High Affinity for Hydroxyapatite Surfaces, Arch Oral Biol 18:1531-1541.

Hay, D.I. (1975): Fractionation of Human Parotid Salivary Proteins and the Isolation of an Histidine-rich Acidic Peptide which shows high Affinity for Hydroxyapatite Surfaces, Arch Oral Biol 20 :553-558.

Hay, D.I. ; Bennick, A. ; Schlesinger, D.H. ; Minaguchi, K. ; Madapallimattam, G. ; and Schluckebier, S.K. (1988): The Primary Structures of Six Human Salivary Acidic Proline-rich Proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f), Biochem J 255:15-21.

Hay, D.I. ; Gibbons, R.J. ; and Spinell, D.M. (1971): Characteristics of Some High Molecular Weight Constituents with Bacterial Aggregating Activity from Whole Saliva and Dental Plaque, Caries Res 5:111-123.

Hay, D.I. and Grøn, P. (1976): Inhibitors of Calcium Phosphate Precipitation in Human Whole Saliva. In: Proceedings, Microbial Aspects of Dental Caries, H.M. Stiles , W.J. Loesche, and T.C. O'Brien, Eds., Sp. Supp. Microbiol Abst, Washington: Information Retrieval , pp. 143-150.

Hay, D.I. ; Smith, D.J. ; Schluckebier, S.K. ; and Moreno, E.C. (1984): Relationship Between Concentration of Human Salivary Statherin and Inhibition of Calcium Phosphate Precipitation in Stimulated Human Parotid Saliva, J Dent Res 63:857-863.

Hoffman, W. ; Junk, A. ; and Geiger, R. (1983): Human Tissue Kallikrein. II. Isolation and Characterization of Human Salivary Kallikrein, Hoppe-Seyler's Z Physiol Chem 364:425-432.

Hogg, S.D. and Embery, G. (1979): The Isolation and Partial Characterization of a Sulfated Glycoprotein from Human Whole Saliva which Aggregates Strains of Streptococcus sanguis but not Streptococcus mutans, Arch Oral Biol 24:791-797.

Holbrook, I.B. and Molan, P.C. (1975): The Identification of a Peptide in Human Parotid Saliva Particularly Active in Enhancing the Glycolytic Activity of the Salivary Micro-organisms, Biochem J 149:489-492.

Hoogendoorn, H. ; Piessens, J.P. ; Scholtes, W. ; and Stoddard, L.A. (1977): Hypothiocyanite Ion; the Inhibitor Formed by the System Lactoperoxidase-Thiocyanate-Hydrogen Peroxide, Caries Res 11:77-84.

Ikemoto, S. ; Hinahara, H. ; Tsuchida, S. ; and Tomita, K. (1985): Phenotype and Gene Frequencies of Acid Phosphatase(s-Acp) in the Human Parotid Saliva, Hum Genet 71:30-32.

Ikemoto, S. ; Minaguchi, K. ; Suzuki, K. ; and Tomita, K. (1977): New Genetic Marker in Human Parotid Saliva (Pm) , Science 197:378-379.

Ikemoto, S. ; Minaguchi, K. ; Tomita, K. ; and Suzuki, K. (1979): A Variant Protein in Human Saliva Detected by SDS Polyacrylamide Gel Electrophoresis and its Inheritance, Ann Hum Genet 43:11-14.

Isemura, S. ; Saitoh, E. ; Ito, S. ; Isemura, M. ; and Sanada, K. (1984b): Cystatin S: A Cysteine Proteinase Inhibitor of Human Saliva, J Biochem 96:1311-1314.

Isemura, S. ; Saitoh, E. ; and Sanada, K. (1980): The Amino Acid Sequence of a Salivary Proline-rich Peptide, P-C, and its Relations to a Salivary Proline-rich Phosphoprotein, Protein C, J Biochem 87:1071-1077.

Isemura, S. ; Saitoh, E. ; and Sanada, K. (1982): Fractionation and Characterization of Basic Proline-rich Peptides of Human Parotid Saliva and the Amino Acid Sequence of Proline-rich Peptide P-E, J Biochem 91:2067-2075.

Isemura, S. ; Saitoh, E. ; and Sanada, K. (1984a): Isolation and Amino Acid Sequence of SAP-1, an Acidic Protein of Human Whole Saliva, and Sequence Homology with Human-trace . J Biochem 96:489-498.

Isemura, S. ; Saitoh, E. ; and Sanada, K. (1986a): Characterization of a New Cystein Proteinase Inhibitor of Human Saliva, Cystatin SN , which is Immunologically Related to Cystatin S, FEBS Lett 198:145-149.

Isemura, S. ; Saitoh, E. ; and Sanada, K. (1987): Characterization and Amino Acid Sequence of a New Acidic Cysteine Proteinase Inhibitor (Cystatin SA) Structurally Closely Related to Cystatin S from Human Whole Saliva, J Biochem 102:693-704.

Isemura, S. ; Saitoh, E. ; Sanada, K. ; and Isemura, M. (1986b): Cystatin S and Related Cysteine Proteinase Inhibitors in Human Saliva. In: Cysteine Proteinases and Their Inhibitors , V. Turk , Ed., Berlin: Walter de Gruyter and Co., pp. 497-505.

Ishizaki, K. ; Noda, A. ; Ikenaga, M. ; Ida, K. ; Omoto, K. ; Nakamura, Y. ; and Matsubara, K. (1985): Restriction Fragment Length Polymorphism Detected by Human Salivary Amylase cDNA, Hum Genet 71:261-262.

Ito, S. ; Isemura, S. ; Saitoh, E. ; Sanada, K. ; Suzuki, T. ; and Shibata, A. (1983): Immunohistochemical Demonstration of Salivary Proline-rich Peptide P-C-like Immunoreactivity in Human Pancreatic β-cells , Acta Endocr 103:544-551.

Ito, S. ; Isemura, S. ; Saitoh, E. ; Suzuki, T. ; Sanada, K. ; and Shibata, A. (1984): A Study on Salivary Proline-rich Peptide P-C with Special Reference to the Presence of Salivary Peptide P-C in the Human Respiratory Tract, Folia Endocrinol Jap 60 :16-22 (in Japanese with English abst.).

Iwamoto, Y. ; Inoue, M. ; Tsunemitsu, A. ; and Matsumura, T. (1967): Some Properties of the Salivary Antibacterial Factors (SA Factor), Arch Oral Biol 12:1009-1012.

Iwamoto, Y. and Matsumura, T. (1966): Purification and Characterization of the Salivary Antibacterial Factor (SA Factor), Arch Oral Biol 12:667-676.

Iwamoto, Y. ; Nakamura, R. ; Tsunemitsu, A. ; and Matsumura, T. (1968): The Heterogeneity of Human Salivary Peroxidase , Arch Oral Biol 13:1015-1018.

Iwamoto, Y. ; Nakamura, R. ; Watanabe, T. ; and Tsunemitsu, A. (1972): Heterogeneity of Peroxidase Related to Antibacterial Activity in Human Parotid Saliva, J Dent Res 51 :503-508.

Jankowski, J.M. ; Krawetz, S.A. ; Walczyk, E. ; and Dixon, G.H. (1986): In vitro Expression of Two Proteins from Overlapping Reading Frames in a Eukaryotic DNA Sequence, J Mol Evolut 24:61-71.

Juriaanse, A.C. and Booij, M. (1979a): Isolation and Partial Characterization of Three Acidic Proteins from Human Submandibular Saliva, Arch Oral Biol 24:621-625.

Juriaanse, A.C. and Booij, M. (1979b): Isolation and Characterization of the Main Neutral Protein from Submandibular Saliva, Arch Oral Biol 24:825-828.

Karn, R.C. ; Friedman, R.D. ; and Merritt, A.D. (1979): Human Salivary Proline-rich (Pr) Proteins: A Post-translational Derivation of the Phenotypes, Biochem Genet 17:1061-1077.

Karn, R.C. ; Goodman, P.A. ; and Yu, P.L. (1985): Description of a Genetic Polymorphism of a Human Proline-rich Salivary Protein, Pc, and its Relationship to other Proteins in the Salivary Protein Complex (SPC), Biochem Genet 23:37-51.

Karn, R.C. ; Schulkin, J.D. ; Merritt, A.D. ; and Newell, R.C. (1973): Evidence for Post-translational Modification of Human Salivary Amylase (Amy,) Isozymes, Biochem Genet 10:341- - 350.

Kauffman, D. ; Hofmann, T. ; Bennick, A. ; and Keller, P. (1986): Basic Proline-rich Proteins from Human Parotid Saliva: Complete Covalent Structures of Proteins IB-1 and IB-6, Biochemistry 25:2387-2392.

Kauffman, D.L. and Keller, P.J. (1979): The Basic Proline-rich Proteins in Human Parotid Saliva from a Single Subject, Arch Oral Biol 24:249-256.

Kauffman, D.L. and Keller, P.J. (1983): Relationship of the Basic Glycoprotein to the Basic Proline-rich Proteins in Human Parotid Saliva, Arch Oral Biol 28:61-67.

Kauffman, D.L. ; Wong, R. ; Bennick, A. ; and Keller, P. (1982): Basic Proline-rich Proteins from Human Parotid Saliva: Complete Covalent Structure of Protein IB-9 and Partial Structure of Protein IB-6, Members of a Polymorphic Pair, Biochemistry 21:6558-6562.

Kauffman, D.L. ; Zager, N.I. ; Cohen, E. ; and Keller, P.J. (1970): The Isozymes of Human Parotid Amylase, Arch Biochem Biophys 137:325-339.

Keller, P.J. ; Kauffman, D.L. ; Allan, B.J. ; and Wil-Liams, B.L. (1971): Further Studies on the Structural Differences between the Isozymes of Human Parotid a-amylase, Biochemistry 10:4867-4874.

Kim, H.S. and Maeda, N. (1986): Structure of Two Haelll-type Genes in the Human Salivary Proline-rich Protein Multigene Family, J Biol Chem 261:6712-6718.

Koide, T. and Odani, S. (1987): Histidine-rich Glycoproteins Evolutionarily Related to Cystatin Superfamily, FEBS Lett 216 :17-21.

Kousvelari, E.E. ; Baratz, R.S. ; Burke, B. ; and Oppenheim, F.G. (1980): Immunological Identification and Determination of Proline-rich Proteins in Salivary Secretions, Enamel Pellicle, and Glandular Tissue Specimens, J Dent Res 59 :1430-1438.

Kretsinger, R.H. (1976): Calcium-bonding Proteins, Ann Rev Biochem 45:239-266.

Kuhn, P. and Tishberger, H. (1980): Amylase1 Polymorphism of Human Parotid Saliva: Detection of a New Allele, AMY15, by Isoelectric Focusing and AMY, Population Data from Germany, Electrophoresis 1:186-190.

Levine, M. and Keller, P.J. (1977): The Isolation of Some Basic Proline-rich Proteins from Human Parotid Saliva, Arch Oral Biol 22:37-41.

Levine, M.J. ; Weill, J.C. ; and Ellison, S.A. (1969): The Isolation and Analysis of a Glycoprotein from Parotid Saliva, Biochim Biophys Acta 188:165-167.

Levine, M.J. ; Ellison, S.A. ; and Bahl, O.P. (1973): The Isolation from Human Parotid Saliva and Partial Characterization of the Protein Core of a Major Parotid Glycoprotein, Arch Oral Biol 18:827-837.

Levine, M.J. ; Herzberg, M.C. ; Levine, M.S. ; Ellison, S.A. ; Stinson, M.W. ; Li, H.C. ; and Van Dyke, T. (1978): Specificity of Salivary-Bacterial Interactions: Role of Terminal Sialic Acid Residues in the Interaction of Salivary Glycoproteins with Streptococcus sanguis and Streptococcus mutans, Infect Immun 19:107-115.

Levine, M.J. ; Reddy, M.S. ; Tabak, L.A. ; Loomis, R.E. ; Bergey, E.J. ; Jones, P.C. ; Cohen, R.E. ; Stinson, M.W. ; and Al-Hashimi, I. (1987): Structural Aspects of Salivary Glycoproteins, J Dent Res 66:436-441.

Loomis, R.E. ; Prakobphol, A. ; Levine, M.J. ; Reddy, M.S. ; and Jones, P.C. (1987): Biochemical and Biophysical Comparison of Two Mucins from Human Submandibular-Sublingual Saliva, Arch Biochem Biophys 258:452-464.

MacKay, B.J. ; Denepitiya, L. ; Iacono, V.J. ; Krost, S.B. ; and Pollock, J.J. (1984a): Growth Inhibitory and Bactericidal Effects of Human Parotid Salivary Histidine-rich Polypeptides on Streptococcus mutans , Infect Immun 44:695-701.

MacKay, B.J. ; Pollock, J.J. ; Iacono, V.J. ; and Baum, B.J. (1984b): Isolation of Milligram Quantities of a Group of Histidine-rich Polypeptides from Human Parotid Saliva, Infect Immun 44 :688-694.

Maeda, N. (1985): Inheritance of the Human Salivary Proline-rich Proteins: A Reinterpretation in Terms of Six Loci Forming Two Subfamilies , Biochem Genet 23:455-464.

Maeda, N. ; Kim, H.S. ; Azen, E.A. ; and Smithies, 0. ( 1985): Differential RNA Splicing and Post-translational Cleavages in the Human Salivary Proline-rich Protein Gene System, J Biol Chem 260:11123-11130.

Makinen, K.K. and Tenovuo, J. (1976): Chromatographic Separation of Human Salivary Peroxidase , Acta Odontol Scand 34 :141-150.

Mamula, P.W. ; Heerema, N.A. ; Palmer, C.G. ; Lyons, K.M. ; and Karn, R.C. (1985): Localization of the Human Salivary Protein Complex (SPC) to Chromosome Band 12pl3.2, Cytogenet Cell Genet 39:279-284.

Mamula, P.W. ; Morley, D.J. ; Larsen, S.H. ; and Karn, R.C. (1988): Expression of Human Salivary Protein Genes, Biochem Genet 26:165-175.

Mandel, I.D. ; Thompson, R.H. ; and Ellison, S.A. (1965): Studies on the Mucoproteins of Human Parotid Saliva , Arch Oral Biol 10:499-507.

Mansson-Rahemtulla, B. ; Rahemtulla, F. ; Baldone, D.C. ; Pruitt, K.M. ; and Hjerpe, A. (1987): Purification and Characterization of Human Salivary Peroxidase, Biochemistry 27:233-239.

Masson, P.L. ; Carbonara, A.O. ; and Heremans, J.F. (1965): Studies on the Proteins of Human Saliva, Biochem Biophys Acta 107:485-500.

Mayo, J.W. and Carlson, D.M. (1974): Protein Composition of Human Submandibular Secretions , Arch Biochem Biophys 161 :134-145.

Merritt, A.D. and Karn, R.C. (1977): The Human a-Amylases. In: Advances in Human Genetics, Vol. 8, H. Harris and K. Hirschom , Eds., New York : Plenum Press, pp. 135-223.

Minaguchi, K. ; Shirotani, T. ; and Suzuki, K. (1988): New Variants of Ps Salivary Polymorphic Proteins , Ann Hum Genet 52:11-16.

Minaguchi, K. and Suzuki, K. (1980): A Supplement of the Studies on Salivary Amylase Isoenzymes, Shikwa Gakuho 80:921 (in Japanese).

Minaguchi, K. and Suzuki, K. (1986): New Salivary Protein Polymorphisms Detected by SDS Polyacrylamide Gel Electrophoresis, J Dent Res 65:326, Abst. No. 1410.

Minaguchi, K. and Suzuki, K. (1988): Genetic Polymorphisms of the Pmol and Pmo2 Salivary Proteins Detected by the Modified Protein Staining Method, Ann Hum Genet 52:177-187.

Minaguchi, K. ; Takaesu, Y. ; Tsutsumi, T. ; and Suzuki, K. (1981): Studies of Genetic Markers in Human Saliva. (VII) Frequencies of the Major Parotid Salivary Glycoprotein (Gl) System in a Japanese Population, Bull Tokyo Dent Coll 22:1-6.

Minakata, K. and Asano, M. (1984): New Protein Inhibitors of Cysteine Proteinases in Human Saliva and Salivary Glands, Hoppe-Seyler's Z Physiol Chem 365:399-403.

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