Tritiated thymidine was injected into 10- and 13-day-old mice because at this age the third molar is at the appropriate stage of development. At set intervals, the mice were killed and the distribution of labeled cells within the dental papilla and follicle examined. The change in labeling index with time was measured for defined areas in the papilla and follicle. It was shown that, during the late bell stage of development, cells moved from the papilla into the follicle. It was concluded that the pulp, rather than the investing layer of the follicle, is the source of the periodontium and that growth of the pulp and periodontal tissues could generate an important force contributing to tooth eruption.
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References
1.
Bryer, L.W. (1957): An Experimental Evaluation of the Physiology of Tooth Eruption, Int Dent J7:432-478.
2.
Cohn, S.A. (1957): Development of the Molar Teeth in the Albino Mouse , Am J Anat101:295-320.
3.
Freeman, E.; Ten Cate, A.R.; and Dickson, J. (1975): Development of a Gomphosis by Tooth Germ Implants in the Parietal Bone of the Mouse, Arch Oral Biol20:139-140.
4.
Gaunt, W.A. (1963): An Analysis of the Growth of the Cheek Teeth of the Mouse, Acta Anat54:220-259.
5.
Gaunt, W.A. (1964): The Development of the Teeth and Jaws of the Albino Mouse, Acta Anat57:267-277.
6.
Gaunt, W.A. (1966): The Disposition of the Developing Cheek Teeth in the Albino Mouse, Acta Anat64:572-585.
7.
Gould, T.R.L.; Melcher, A.H.; and Brunette, D.M. (1980): Migration and Division of Progenitor Cell Populations in Periodontal Ligament After Wounding, J Periodont Res15:20-42.
8.
Hay, M.F. (1961): The Development in vivo and in vitro of the Lower Incisor and Molars of the Mouse, Arch Oral Biol3 :86-109.
9.
Hoffman, R.L. (1960): Formation of Periodontal Tissues Around Subcutaneously Transplanted Hamster Molars, J Dent Res39 :781-797.
10.
Holtzer, H.; Rubinstein, N.; Fellini, S.; Yeoh, G.; Chi, J.; Birnbaum, J.; and Okayama, M. (1975): Lineages, Quantal Cell Cycles, and the Generation of Cell Diversity, Q Rev Biophys8:523-557.
11.
McCulloch, C.A.G. and Melcher, A.H. (1983): Cell Migration in the Periodontal Ligament of Mice, J Periodont Res18 :339-352.
12.
Osborn, J.W. (1974): On the Control of Tooth Replacement in Reptiles and its Relationship to Growth, J Theoret Biol46 :509-527.
13.
Osborn, J.W. (1979): A Cladistic Interpretation of Morphogenesis, J Biol Buccale6:327-337.
14.
Osborn, J.W. (1984): From Reptile to Mammal: Evolutionary Considerations of the Dentition with Emphasis on Tooth Attachment, Symp Zool Soc Lond (No. 52):549-572.
15.
Osborn, J.W. and Ten Cate, A.R. (1983): Advanced Dental Histology, 4th ed., Bristol: John Wright & Sons Ltd.
16.
Osman, A. and Ruch, J.W. (1978): Contribution a I'Etude des Parametres du Cycle Cellulaire au Cours de l'Odontogenese chez la Souris, J Biol Buccale6:43-54.
17.
Palmer, R.M. and Lumsden, A.S. (1987): Development of Periodontal Ligament and Alveolar Bone in Homografted Recombinations of Enamel Organs and Papillary, Pulpal and Follicular Mesenchyme in the Mouse, Arch Oral Biol32:281-289.
18.
Perera, K.A.S. and Tonge, C.M. (1981): Fibroblast Cell Population Kinetics in the Mouse Molar Periodontal Ligament and Tooth Eruption, J Anat133:281-300.
19.
Ten Cate, A.R. (1969): The Development of the Periodontium. In: The Biology of the Periodontium, A.H. Melcher and W.H. Bowen, Eds., London: Academic Press.
20.
Ten Cate, A.R. (1972): Cell Division and Periodontal Ligament Formation in the Mouse, Arch Oral Biol17:1781-1784.
21.
Ten Cate, A.R. and Mills, C. (1972): The Development of the Periodontium: The Origin of Alveolar Bone, Anat Rec173 :69-78.
22.
Ten Cate, A.R.; Mills, C.; and Solomon, G. (1971): The Development of the Periodontium. A Transplantation and Autoradiographic Study, Anat Rec170:365-380.
23.
Van Hassel, H.J. and McMinn, R.G. (1972): Pressure Differential Favouring Tooth Eruption in the Dog, Arch Oral Biol17 :183-190.
24.
Yoshikawa, D.K. and Kollar, E.J. (1981): Recombination Experiments on the Odontogenic Roles of Mouse Dental Papilla and Dental Sac Tissues in Ocular Grafts, Arch Oral Biol26:303-307.
