In order to correlate pathological changes of mouse parotid glands with their sialographic images, we conducted studies on mice with known pathological changes: mice with Stensen's duct ligated, NZB mice with a systemic auto-immune disease, and aged mice. The sialographic images were found to be specific for the pathological changes: The glands after ligation of Stensen's duct were characterized by dilated, large excretory ducts with a reduced system of peripheral ducts; the glands of NZB mice showed lobular leakage of the contrast medium from small excretory ducts; and the glands of aged mice showed a great reduction in the ductal system. It is concluded that sialography yields useful information on the pathological changes of the ductal systems in the mouse parotid gland.
Get full access to this article
View all access options for this article.
References
1.
Andrew, W. (1949): Age Changes in the Parotid Glands of Wistar Institute Rats with Special Reference to the Occurrence of Oncocytes in Senility, Am J Anat85:157-197.
2.
Andrew, W. (1952): A Comparison of Age Changes in Salivary Glands of Man and of Rat, J Gerontol7:178-190.
3.
Bertram, U. (1967): Xerostomia, Acta Odontol Scand25 (Supp. 49).
4.
Bhaskar, S.N.; Bolden, T.E.; and Weinmann, J.P. (1956): Experimental Obstructive Adenitis in the Mouse , J Dent Res35 :852-862.
5.
Carlsoo, B. and Ostberg, Y. (1978): Ultrastructural Observations on the Parotitis Autoimmunica in the NZB/NZW Hybrid Mice, Acta Otolaryngol85:298-306.
6.
Domon, M. and Kurabayashi, T. (1987): Postnatal Development of the Duct System in the Mouse Parotid Gland, Anat Rec217:391-394.
7.
Domon, M. and Shiga, Y. (1986): Sialographic Investigations on the Anatomy of Mouse Parotid Glands, Anat Rec214:165-167.
8.
Emmelin, N.; Garrett, J.R.; and Gjorstrup, P. (1977): Supporting Effects of Myoepithelial Cells in Submandibular Glands of Dogs When Acting against Increased Intraluminal Pressure, J Physiol268:73-85.
9.
Emmelin, N.; Garrett, J.R.; and Ohlin, P. (1974): Secretory Activity and the Myoepithelial Cells of Salivary Glands after Duct Ligation in Cats, Arch Oral Biol19:275-283.
10.
Ericson, S. (1968): The Parotid Gland in Subjects with and without Rheumatoid Arthritis. A Sialographic and Physiologic Study, Acta Radiol (Supp 275).
11.
Garrett, J.R.; Gjorstrup, P.; Klinger, A.H.; and Parsons, P.A. (1976): Myoepithelial Activity and the Appearances of Sialograms: A Possible Role in the Formation of Sialectasis, Br J Radiol49:1013-1017.
12.
Garrett, J.R. and Parsons, P.A. (1976): Movement of Horseradish Peroxidase in Rabbit Submandibular Glands after Ductal Injection, Histochem J8:177-189.
13.
Garrett, J.R. and Parsons, P.A. (1979): Changes in the Main Submandibular Salivary Duct of Rabbits Resulting from Ductal Ligation, Z Mikrosk Anat Forsch93:593-608.
14.
Harrison, J.D. and Garrett, J.R. (1972): Mucocele Formation in Cats by Glandular Duct Ligation , Arch Oral Biol17 :1403-1414.
15.
Holmes, M.C. and Burnet, F.M. (1963): The Natural History of Autoimmune Disease in NZB Mice. A Comparison with the Pattern of Human Autoimmune Manifestation, Ann Intern Med59:265-276.
16.
Kessler, H.S. (1968): A Laboratory Model for Sjogren's Syndrome, Am J Pathol52:671-685.
17.
Keyfs, G.: Vickers, R.A.; and Kersey, J.H. (1977): Immunopathology of Sjogren-like Disease in NZB/NZW Mice, J Oral Pathol6:288-295.
18.
Lilly, G.E.; Cutcher, J.L.; and Steiner, M. (1968): Radiopaque Contrast Mediums: Effects on Dog Salivary Gland and Subcutaneous Tissues, J Oral Surg26:94-98.
19.
Malkin, M. and Hirsch, A.C. (1968): Sjogren's Syndrome: A Radiographic Study, J Oral Surg26:334-337.
20.
Oliver, C. and Hand, A.R. (1978): Uptake and Fate of Luminally Administered Horseradish Peroxidase in Resting and Isoproterenol-stimulated Rat Parotid Acinar Cells , J Cell Biol76:207-220.
21.
Qwarnstrom, E.E.; Gjorstrup, P.; and Omnell, K.-A. (1981): Sialography of the Submandibular Gland in the Rat: An Experimental Model Including Measurement of Intraglandular Pressure , Dentomaxillofac Radiol10:27-34.
22.
Qwarnstrom, E.E. and Hand, A.R. (1982a): A Light and Electron Microscopic Study of the Distribution and Effects of Watersoluble Radiographic Contrast Medium after Retrograde Infusion into the Rat Submandibular Gland, Arch Oral Biol27:117-127.
23.
Qwarnstrom, E.E. and Hand, A.R. (1982b): A Light and Electron Microscopic Study of the Effects of Retrograde Infusion of Lipid-soluble Radiographic Contrast Medium into the Rat Submandibular Gland, Arch Oral Biol27:705-714.
24.
Qwarnstrom, E.E. and Hand, A.R. (1987): The Effects of Increased Intraluminal Pressure on Rat Submandibular Gland Morphology, J Dent Res66:592-593.
25.
Qwarnstrom, E.E. and Omnell, K.-A. (1980): Normal Radiographic Anatomy of the Rat Submandibular Gland, Dentomaxillofac Radiol9:81-84.
26.
Rubin, P. and Holt, J.F. (1957): Secretory Sialography in Diseases of the Major Salivary Glands, Am J Roentgenol Rad Therapy77:575-598.
27.
Schneyer, C.A. and Schneyer, L.H. (1961): Secretion by Salivary Glands Deficient in Acini , Am J Physiol201:939-942. Scott, J. (1977a): Quantitative Age Changes in the Histological Structure of Human Submandibular Salivary Glands, Arch Oral Biol22:221-227.
28.
Scott, J. (1977b): A Morphometric Study of Age Changes in the Histology of the Ducts of Human Submandibular Salivary Glands, Arch Oral Biol22:243-249.
29.
Shiba, R.; Hamada, T.; and Kawakatsu, K. (1972): Histochemical and Electron Microscopical Studies on the Effects of Duct Ligation of Rat Salivary Glands, Arch Oral Biol17 :299-309.
30.
Standish, S.M. and Shafer, W.G. (1957): Serial Histologic Effects of Rat Submaxillary and Sublingual Salivary Gland Duct and Blood Vessel Ligation, J Dent Res36:866-879.
31.
Tamarin, A. (1971): Submaxillary Gland Recovery from Obstruction. 1. Overall Changes and Electron Microscopic Alterations of Granular Duct Cells , J Ultrastruct Res34:276- 287.
32.
Tamarin, A. (1979): The Leukocytic Response in Ligated Rat Submandibular Glands, J Oral Pathol8:293-304.
33.
Trester, P.H. (1968): The Development and Use of Contrast Media in Sialography , J Can Dent Assoc34:210-213.
34.
Waterhouse, J.P.; Chisholm, D.M.; Winter, R.B.; Patel, M.; and Yale, R.S. (1973): Replacement of Functional Parenchymal Cells by Fat and Connective Tissue in Human Submandibular Salivary Glands: An Age-related Change, J Oral Pathol2:16-27.
