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Abstract

Fluoride incorporation into human enamel from an experimental sealant resin in vivo was investigated. The sealant consisted of a newly synthesized methacryloyl fluoride-methyl methacrylate (MF-MMA) copolymer resin, which contains acidic fluoride covalently bonded to carbonyl groups and releases fluoride ions slowly by hydrolysis in an aqueous environment. This experimental sealant was applied to the enamel of permanent pre-molars and the control sealant without MF-MMA copolymer to that of the contralateral teeth. Fluoride concentration was determined by an enamel biopsy procedure with acid-etching four weeks after the sealant application. As much as 3500 ppm fluoride was found to be deposited at 10 μm depth in the enamel under the MF-MMA copolymer sealant. The increase in fluoride concentration was significant even at 60 μm. Of the fluoride incorporated into the enamel, from 70 to 80% was present as a tightly bound form. This resin sealant is expected to protect the enamel from caries attack even after detachment of the sealant.

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References

American Dental Association (1984): Pit and Fissure Sealant Use, J Am Dent Assoc 108: 310-322.

Caslavska, V. ; Moreno, E.C. ; and Brudevold, F. (1975): Determination of the Calcium Fluoride Formed from in vitro Exposure of Human Enamel to Fluoride Solutions, Arch Oral Biol 20: 333-339.

Hanes, C.M. and Hanes, P.J. (1986): Effective Delivery Systems for Prolonged Fluoride Release: Review of Literature, J Am Dent Assoc 113: 431-436.

Houpt, M. and Shey, Z. (1983): The Effectiveness of a Fissure Sealant after Six Years, Pediatric Dent 5: 104-106.

Jenkins, G.N. (1963): Theories on the Mode of Action of Fluoride in Reducing Dental Decay, J Dent Res 42: 444-452.

Kadoma, Y. ; Kojima, K. ; and Masuhara, E. (1983): Studies on Dental Fluoride-releasing Polymers. 4. Fluoridation of Human Enamel by Fluoride-containing Sealant, Biomaterials 4: 89-93.

Kadoma, Y. and Masuhara, E. (1981): Controlled Release of Fluoride Ions from Methacryloyl Fluoride-Methyl Methacrylate Copolymers. 1. Synthesis of Methacryloyl Fluoride-Methacrylate Copolymers, Makromol Chem 182: 273-277.

Kadoma, Y. ; Masuhara, E. ; and Anderson, J.M. (1982): Controlled Release of Fluoride Ions from Methacryloyl Fluoride-Methyl Methacrylate Copolymers, 2. Solution Hydrolysis and Release of Fluoride Ions, Macromolecules 15: 1119-1123.

Masuhara, E. ; Kadoma, Y. ; and Fujisawa, S. (1985): Current Status of Release of Fluoride Ions and Other Bioactive Agents From Dental Materials: Prospects for Controlled Release , Crit Rev Ther Drug Carrier Syst 1 : 91-119.

10.

Masuhara, E. ; Kojima, K. ; and Kadoma, Y. (1983): Release of Fluoride Ions from Methacryloyl Fluoride-Methyl(Methacrylate) Copolymer Film, Kobunshi Ronbunshu 40: 151-156.

11.

Mertz-Fairhurst, E.J. ; Fairhurst, C.W. ; Williams, J.E. ; Della-Giustina, V.E. ; and Brooks, J.D. (1982): A Comparative Clinical Study of Two Pit and Fissure Sealants: Six-year Results in Augusta, GA, J Am Dent Assoc 105: 237-239.

12.

Mertz-Fairhurst, E.J. ; Fairhurst, C.W. ; Williams, J.E. ; Della-Giustina, V.E. ; and Brooks, J.D. (1984): A Comparative Clinical Study of Two Pit and Fissure Sealants: 7-year Results in Augusta, GA, J Am Dent Assoc 109: 252-255.

13.

Mellberg, J.R. ; Laakso, P.V. ; and Nicholson, C.R. (1966): The Acquisition and Loss of Fluoride by Topically Fluoridated Human Tooth Enamel, Arch Oral Biol 11: 1213-1220.

14.

National Institutes Of Health (1984): Consensus Development Conference Statement on Dental Sealants in the Prevention of Tooth Decay, J Am Dent Assoc 108: 233-236.

15.

Rawls, H.R. and Querens, A.E. (1980): The Potential of an Adhesive Anion-exchange Resin as a Fluoride-releasing Sealant, J Dent Res 59A: 491, Abstr. No. 895.

16.

Rawls, H.R. and Zimmerman, B.F. (1983): Fluoride-exchanging Resins for Caries Protection , Caries Res 17: 32-43.

17.

Rock, W.P. and Anderson, R.J. (1982): A Review of Published Fissure Sealant Trials Using Multiple Regression Analysis, J Dent 10: 39-43.

18.

Swartz, M.L. ; Phillips, R.W. ; Norman, R.D. ; Eliason, S. ; Rhodes, B.F. ; and Clark, H.E. (1976): Addition of Fluoride to Pit and Fissure Sealants-A Feasibility Study, J Dent Res 55: 757-771.

19.

Underwood, M.L. ; Rawls, H.R. ; and Zimmerman, B.F. (1987): Clinical Evaluation of a Fluoride-exchanging Resin as an Orthodontic Adhesive, J Dent Res 66: 349, Abstr. No. 1942.

Incorporation into Human Enamel of Fluoride Slowly Released from a Sealant in vivo

Abstract

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