Ultrastructural alterations occurring in human salivary glands as a result of a variety of diseases are described. Major changes in these organs in cases of cystic fibrosis are probably the result of duct blockage, as indicated by study of chronically inflamed salivary glands. A new disease of salivary glands is reported in which parotid serous granules are distorted by bundles of fine filaments, which may be due to the untoward polymerization of a secretory protein, perhaps proline-rich protein. Finally, a clear-cell adenocarcinoma of palatine gland origin is described in which the nuclei display complex pseudoinclusions and the cytoplasm contains numerous herpes-type viruses.
Get full access to this article
View all access options for this article.
References
1.
Bailleul, V.; Richet, C.; Hayem, A.; and Degand, P. (1977): Propriétés Rhéologiques des Secretions Bronchiques: Mise en Évidence et Rôle de Polypeptides Riches en Proline, Clin Chim Acta74:135-123.
2.
Barbero, G.J. and Sibinga, M.S. (1962): Enlargement of the Submaxillary Salivary Glands in Cystic Fibrosis, Pediatrics29:788-793.
3.
Blomfield, J.; Dascalu, J.; Van Lennep, E.W.; and Brown. J.M. (1973); Hypersecretion of Zymogen Granules in the Pathogenesis of Cystic Fibrosis, Gut14:558-565.
4.
Blomfield, J.,; Allars, H.M.; Rush, A.R.; Van Lennep, E.W.; and Brown, J.M. (1974a): Parotid Serous Hypersecretion in Cystic Fibrosis , Aust Pædiat J10:75-81.
5.
Blomfield. J.; Van Lennep, E.W.; Shorey, C.D.; Malin, A.S.; Dascalu, J.; and Brown. J.M. (1974b): Ultrastructure of the in vitro Formation of Hydroxyapatite in Submandibular Saliva of Children with Cystic Fibrosis, Arch Oral Biol19:1153-1160.
6.
Bolande, R.P. and Towler W.F. ( 1973); Terminal Autonomic Nervous System in Cystic Fibroxis. An Ultrastructural and Histochemical Study of Labial Salivary Gland Biopsy Specimens, Arch Pathol95:172-177.
7.
Caldwell, R.C. and Shackleford, J.M. (1967): A Chemical, Immunological and Electron-microscopic Study of Centrifuged Human Submaxillary Saliva, Arch Oral Biol12:333-340.
8.
Chernick, W.S. and Barbero, G.J. (1963): Studies on Human Tracheobronchial and Submaxillary Secretions in Normal and Pathophysiological Conditions, Ann NY Acad Sci106:698-798.
9.
Dales, S. (1963): Association Between the Spindle Apparatus and Reovirus, Proc Natl Acad Sci50:268-275.
10.
Davies, K.J. and Garrett, J.R. (1981): Ciliated Ductal Cells in Obstructive Sialadenitis , J Microscopy123:RP1-RP2.
11.
Dawes, C. (1981): The Effects of Exercise on Protein and Electrolyte Secretion in Parotid Saliva, J Physiol Lond320:139-148.
12.
di Sant'Agnese, P.A. and Davis, P.B. (1976): Research in Cystic Fibrosis, N Engl J Med295:481-495; 534-541; 597-602.
13.
Doggett, R.G.; Bentinck, B.; and Harrison, G.M. (1971): Structure and Ultrastructure of the Labial Salivary Glands in Patients with Cystic Fibrosis, J Clin Pathol24:270-282.
14.
Evans, R.W. and Cruickshank, A.H. (1970): Epithelial Tumours of the Salivary Glands, Philadelphia; W.B. Saunders Company, p. 11.
15.
Frey, H.B.; Kurtz, S.M.: Spock, A.; and Capp M.P. (1964): Light and Electron Microscopic Examination of the Small Bowel of Children with Cystic Fibrosis, J Pediat64:575-579.
16.
Garrett, J.R. and Parsons, P.A. (1979): Changes in the Main Submandibular Salivary Duct of Rabbits Resulting from Ductal Ligation. Z Mikrosk Anat Forsch93:593-608.
17.
Gorlin, R.J. and Goldman, H.M. (1970): Thomas Oral Pathology, 6th ed., Vol. 2, St. Louis: C.V. Mosby Company, pp. 962-1070.
18.
Hage E. and Andersen, F.U. (1972): Light and Electron Microscopical Studies of Rectal Biopsies in Cystic Fibrosis, Acta Pathol Microbiol Scand Sect A80:345-350.
19.
Kasnic, G., Jr.; Sayeed, A.: and Azar, H.A. (1982): Nuclear and Cytoplasmic Inclusions in Disseminated Human Cytomegalovirus Infection, Ultrastruct Pathol3:229-235.
20.
Kousvelari, E.E.; Oppenheim, E.G.; and Cutler, L.S. (1982): Ultrastructural Localization of Salivary Acidic Proline-rich Proteins from Macaco fascicularis, J Histochem Cytochem30:274-278.
21.
Lev, R. and Spicer, S.S. (1965): A Histochemical Comparison of Human Epithelial Mucins in Normal and in Hypersecretory States Including Pancreatic Cystic Fibrosis, Am J Pathol46:23- 47.
22.
Mandel, I.D.; Kutscher, A.; Denning, C.R.; Thompson, R.H., Jr. ; and Zegarelli, E.V. (1967): Salivary Studies in Cystic Fibrosis, Am J Dis Child113:431-438.
23.
Mandel, I.D.; Thompson, R.H.; Wotman, S.; Taubman, M.; Kutscher, A.,H.; Zegarelli, E.; Denning, C.R.; Botwick, J.T.; and Fahn, B.S. (1965): Parotid Saliva in Cystic Fibrosis. II. Electrolytes and Protein-bound Carbohydrates, Am J Dis Child110:646-651.
24.
McGavran, M.H. and Smith, M.G.1965): Ultrastructural, Cytochemical, and Microchemical Observations on Cytomegalovirus (Salivary Gland Virus) Infection of Human Cells in Tissue Culture, Exp Molec Pathol4:1-40.
25.
Munger B.L.; Brusilow, S.W.; and Cooke, R.E. (1961): An Electron Microscopic Study of Eccrine Sweat Glands in Patients with Cystic Fibrosis of the Pancreas, J Pediat59:497-511.
26.
Porta, E.A.; Stein, A.A.; and Patterson, P. (1964): Ultrastructural Changes of the Pancreas and Liver in Cystic Fibrosis, Am J Clin Pathol42:451-465.
27.
Rauch, S. (1959): Die Speicheldrüsen des Menschen. Anatomie, Physiologie und Klinische Pathologie, Stuttgart: Georg Thieme Verlag.
28.
Riva, A.; Motta, G.; and Riva-Testa, F. (1974): Ultrastructural Diversity in Secretory Granules of Human Major Salivary Glands, Am J Anat139:293-298.
29.
Riva, A. and Riva-Testa, F. (1973): Fine Structure of Acinar Cells of Human Parotid Gland, Anat Rec176:149-166.
30.
Scott, J. (1978): The Prevalence of Consolidated Salivary Deposits in the Small Ducts of Human Submandibular Glands, J Oral Pathol7:28-37.
31.
Seifert, G. and Wopersnow, R., (1985): Die obstruktive Sialadenitis. Morphologische Analyse und Subklassifikation von 696 Fällen, Pathologie6:177-189.
32.
Shackleford. J.M. and Bentley, H.P., Jr. (1964): Carbohydrate Histochemistry of the Salivary Glands and Pancreas in Cystic Fibrosis, J Histochem Cytochem12:512-521.
33.
Shiba, R.; Hamada. T.; and Kawakatsu, K. (1972): Histochemical and Electron Microscopical Studies on the Effect of Duct Ligation of Rat Salivary Glands, Arch Oral Biol17:299-309.
34.
Shipkey, F.H.; Erlandson, R.A.: Bailey, R.B.; Babcock, V.I.; and Southam, C.M. (1967): Virus Biographies. II. Growth of Herpes Simplex Virus in Tissue Culture, Exp Molec Pathol6:39-67.
Sweney, L. and Warwick, W.J. (1968): Involvement of the Labial Salivary Gland in Patients with Cystic Fibrosis. III. Ultrastructural Changes, Arch Pathol86:413-418.
37.
Tamarin, A. (1967): Secretory Cell Alterations Associated with Submaxillary Gland Duct Ligation. In: Secretory Mechanisms of Salivary Glands , L.H. Sehneyer and C.A. Schneyer, Eds., New York: Academic Press, pp. 220-235.
38.
Tamarin, A. (1979): The Leukocytic Response in Ligated Rat Submandibular Glands, J Oral Pathol8:293-304.
39.
Tandler B. (1962): Ultrastructure of the Human Submaxillary Gland. I. Architecture and Histological Relationships of the Secretory Cells, Am J Anat111:287-307.
40.
Tandler, B. (1965): Electron Microscopical Observations on Early Sialoliths in a Human Submaxillary Gland, Arch Oral Biol10:509-522.
41.
Tandler, B. (1977): Ultrastructure of Chronically Inflamed Human Submandibular Glands, Arch Pathol Lab Med101:425-431.
42.
Tandler, B. and Erlandson, R.A. (1972): Ultrastructure of the Human Submaxillary Gland. IV. Serous Granules, Am J Anat135:419-434.
43.
Tandler. B. and Riva, A. (1986): Salivary Glands. In: Human Oral Embryology and Histology, I.A. Mjör and O. Fejerskov, Eds., Copenhagen : Munksgaard International Publishers, Ltd., pp. 243-284.
44.
Testa Riva, F. (1977): Ultrastructure of Human Submandibular Gland, J Submicrosc Cytol9:251-266.
45.
Vortel, V. and Sazama. L. (1977): Rasinkovy Epitel ve Vyvodech Podčelistni Slinne Žlázy, Cesk Pathol13:134-137.
46.
Warwick, W.J.; Bernard, B.; and Meskin, L.H. (1964): The Involvement of the Labial Mucous Salivary Gland in Patients with Cystic Fibrosis, Pediatrics34:621-628.
47.
Wiesmann. U.N.; Boat, T.F.; and di Sant'Agnese, P.A. (1972): Flow-rates and Electrolytes in Minor-salivary-gland Saliva in Normal Subjects and Patients with Cystic Fibrosis, LancetII:510-512.
